Construction and structure-activity relationships of chimeric prourokinase derivatives with intrinsic thrombin-inhibitory potential

Protein Engineering

Volumn 9, Issue 2, 1996, Pages 213-223

  Wnendt, Stephan ^a   Janocha, Elke ^a   Schneider, Johannes ^a   Steffens, Gerd J ^a,b  

^a GRÜNENTHAL GMBH   (Germany)

^b Marienhof Laboratorien   (Germany)

Author keywords

Fibrinolysis; Hirudin; Prourokinase; Thrombin; Thrombin receptor

Indexed keywords

ANTICOAGULANT AGENT; CHIMERIC PROTEIN; MUTANT PROTEIN; PROTEINASE; PROUROKINASE; RECOMBINANT PROTEIN; THROMBIN INHIBITOR;

ANTICOAGULATION; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; ENZYME ACTIVE SITE; ENZYME STRUCTURE; KINETICS; KRINGLE DOMAIN; POINT MUTATION; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANTITHROMBINS; BINDING SITES; BLOOD COAGULATION; CLONING, MOLECULAR; ESCHERICHIA COLI; FIBRINOGEN; GENE EXPRESSION; HIRUDINS; HUMANS; KINETICS; KRINGLES; MOLECULAR SEQUENCE DATA; RECEPTORS, THROMBIN; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; THROMBIN; URINARY PLASMINOGEN ACTIVATOR;

EID: 0029926586     PISSN: 02692139     EISSN: None     Source Type: Journal    
DOI: 10.1093/protein/9.2.213     Document Type: Article

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