Modulation of experimental allergic encephalomyelitis in mice by immunization with a peptide specific for the γδ T cell receptor

Immunology and Cell Biology

Volumn 75, Issue 1, 1997, Pages 102-106

  Olive, Colleen ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

central nervous system (CNS); experimental allergic encephalomyelitis (EAE); peptide immunization, T cell receptor; T cells

Indexed keywords

SYNTHETIC PEPTIDE; T LYMPHOCYTE RECEPTOR;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DISEASE PREDISPOSITION; FEMALE; IMMUNIZATION; IMMUNOMODULATION; MOUSE; NONHUMAN;

ANIMALIA;

EID: 0031040642     PISSN: 08189641     EISSN: None     Source Type: Journal    
DOI: 10.1038/icb.1997.14     Document Type: Article

References (26)

1. Steinman L. The development of rational strategies for selective immunotherapy against autoimmune demyelinating disease. Adv. Immunol. 1991; 49: 357-621.
2. Lehmann PV, Forsthuber T, Miller A, Sercarz EE. Spreading of T cell autoimmunity to cryptic determinants of an autoantigen. Nature 1992; 358: 155-7.
3. Heber-Katz E, Acha-Orbea H, The V-region disease hypothesis: evidence from autoimmune encephalomyelitis. Immunol. Today 1989; 10: 164-9.
4. Su X-M, Sriram S, Analysis of TCR Vβ gene usage and encephalitogenicity of myelin basic protein peptide p91-103 reactive T cell clones in SJL mice: Lack of evidence for V gene hypothesis. Cell. Immunol. 1992; 141: 485-95.
5. Bell RB, Lindsey JW, Sobel RA, Hodgkinson S, Steinman L. Diverse T cell receptor Vβ gene usage in the central nervous system in experimental allergic encephalomyelitis. J. Immunol. 1993; 150: 4085-92.
6. Acha-Orbea H, Mitchell DJ, Timmermann L et al. Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell 1988; 54: 263-73.
7. Zamvil SS, Mitchell DJ, Lee NE et al. Predominant expression of a T cell receptor Vβ gene subfamily in autoimmune encephalomyelitis. J. Exp. Med. 1988; 167: 1586-96.
8. Sakai K, Sinha AA, Mitchell DJ et al. Involvement of distinct murine T cell receptors in the autoimmune encephalitogenic response to nested epitopes of myelin basic protein. Proc. Natl Acad. Sci. USA 1988; 85: 8608-12.
9. Padula SJ, Lingenheld EG, Stabach PR, Chou C-HJ. Kono DH, Clark RB. Identification of encephalitogenic Vβ-4- bearing T cells in SJL mice. Further evidence for the V region disease hypothesis? J. Immunol. 1991; 146: 879-83.
10. Urban JL, Kumar V, Kono DH et al. Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises the possibility for antibody therapy. Cell 1988; 54: 577-92.
11. Howell MD, Winters ST, Olee T, Powell HC, Carlo DJ, Brostoff SW. Vaccination against experimental allergic encephalomyelitis with T cell receptor peptides. Science 1989; 246: 668-70.
12. Offner H, Hashim GA, Vanderbark AA. T cell receptor peptide therapy triggers autoregulation of experimental encephalomyelitis. Science 1991; 251: 430-2.
13. Desquenne-Clark L, Esch TR, Otvos L, Heber-Katz E. T cell receptor peptide immunization leads to enhanced and chronic experimental allergic encephalomyelitis. Proc. Natl Acad. Sci. USA 1991; 88: 7219-23.
14. Racke MK, Quigley L, Cannella B, Raine CS, McFarlin DE, Scott DE. Superantigen modulation of experimental allergic encephalomyelitis: Activation or anergy determines outcome. J. Immunol. 1994; 152: 2051-9.
15. Freedman MS, Ruijs TCG, Selin LK, Antel JP. Peripheral blood γ-δ T cells lyse fresh human brain-derived oligodendrocytes. Ann. Neurol. 1991; 30: 794-800.
16. + oligodendrocytes in multiple sclerosis. Proc. Natl Acad. Sci. USA 1991; 88: 6452-6.
17. Gao YL, Brosnan CF, Raine CS. Experimental autoimmune encephalomyelitis. Qualitative and semiquantitative differences in heat shock protein 60 expression in the central nervous system. J. Immunol. 1995; 154: 3548-56.
18. Hvas J, Oksenberg JR, Fernando R, Steinman L, Bernard CCA. γδ T cell receptor repertoire in brain lesions of patients with multiple sclerosis. J. Neuroimmunol. 1993; 46: 225-34.
19. Wucherpfennig KW, Newcombe J, Li H, Keddy C, Cuzner ML. γδ T cell receptor repertoire in acute multiple sclerosis lesions. Proc Natl Acad. Sci. USA 1992; 89: 4588-92.
20. + T cells as a mechanism for remission from experimental allergic encephalomyelitis. J. Neuroimmunol. 1993; 44: 193-8.
21. Olive C. γδ T cell receptor variable region usage during the development of experimental allergic encephalomyelitis. J. Neuroimmunol. 1995; 62: 1-8.
22. Houghten RA. General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids. Proc Natl Acad. Sci. USA 1985; 82: 5131-5.
23. Houghten RA, Bray MK, Degraw ST, Kirby CJ. Simplified procedure for carrying out simultaneous multiple hydrogen fluoride cleavages of protected peptide resins. Intl. J Pept. Protein Res. 1986; 27: 673-80.
24. Rajan AJ, Gao Y-L, Raine CS, Brosnan CF. A pathogenic-role for γδ T cells in relapsing-remitting experimental allergic encephalomyelitis in the SJL mouse. J. Immunol. 1996; 157: 941-9.
25. Brostoff SW, Howell MD. Immunoregulation of autoimmune disease by vaccination with T cell receptor peptides. Ann. NY Acad. Sci. 1991; 636: 71-8.
26. Burns J, Bartholomew B, Littlefield K. γδ T cells participate in the immune response against activated, myelin basic protein-specific, human T cells. J. Neuroimmunol. 1995; 58: 177-82.