Crystal dissolution-controlled release systems: I. Physical characteristics and modeling analysis

Journal of Controlled Release

Volumn 45, Issue 1, 1997, Pages 87-94

  Mallapragada, Surya K ^a,b   Peppas, Nikolaos A ^a  

^a PURDUE UNIVERSITY   (United States)

^b IOWA STATE UNIVERSITY   (United States)

Author keywords

Controlled drug delivery; Crystallinity; Dissolution; Hydrogels; Swelling controlled release systems

Indexed keywords

METRONIDAZOLE;

ARTICLE; CONTROLLED RELEASE FORMULATION; CRYSTALLIZATION; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SOLUBILITY; HYDROGEL; MATHEMATICAL MODEL; PRIORITY JOURNAL;

EID: 0031036803     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(96)01549-0     Document Type: Article

References (20)

1. N.A. Peppas and R. Langer, New challenges in biomaterials, Science 263 (1994) 1715-1720.
2. N.A. Peppas, Physiologically responsive hydrogels, J. Bioact. Compat. Polym. 6 (1991) 241-246.
3. P.I. Lee, Differential release of a solute from a polymeric system - approximate analytical solutions, J. Membr. Sci. 7 (1980) 255-265.
4. P.I. Lee and N.A. Peppas, Prediction of polymer dissolution in swellable controlled release systems, J. Control. Rel. 6 (1981) 207-215.
5. R.K. Korsmeyer, S.R. Lustig and N.A. Peppas, Solute and penetrant diffusion in swellable polymers, J. Polym. Sci., Polym. Phys. 24 (1986) 395-408.
6. P. Colombo, Swelling-controlled release in hydrogel matrices for oral route, Adv. Drug. Deliv. Rev. 11 (1993) 37-57.
7. N.B. Graham and M.E. McNeill, Hydrogels for controlled drug delivery, Biomaterials 5 (1984) 27-36.
8. R.S. Harland and N.A. Peppas, Solute diffusion in swollen membranes VII. Diffusion in semicrystalline networks, Coll. Polym. Sci. 267 (1989) 218-225.
9. N.A. Peppas and C.T. Reinhart, Solute diffusion in swollen membranes. Part I. A new theory, J. Membr. Sci. 15 (1983) 275-287.
10. S.K. Mallapragada and N.A. Peppas, Dissolution mechanism of semicrystalline poly(vinyl alcohol) in water, J. Polym. Sci., Polym. Phys. 34 (1996) 1339-1346.
11. S.K. Mallapragada, N.A. Peppas and P. Colombo, Crystal dissolution-controlled release systems: II. Metronidazole release from semicrystalline poly(vinyl alcohol) systems, J. Biomed. Mater. Res. (in press).
12. S.K. Mallapragada and N.A. Peppas, Crystal unfolding and chain disentanglement during semicrystalline polymer dissolution, Am. Inst. Chem. Eng. J. (in press).
13. H. Fujita, Diffusion in polymer-diluent systems, Fortschr. Hochpolym.-Forsch. 3 (1961) 1-47.
14. N.A. Peppas, J.C. Wu and E.D. von Meerwall, Mathematical modeling and experimental characterization of polymer dissolution, Macromolecules 27 (1994) 5626-5638.
15. B. Narasimhan and N.A. Peppas, Disentanglement and reptation during dissolution of rubbery polymers, J. Polym. Sci. Polym. Phys. 34 (1996) 941-957.
16. J.S. Papanu, D.S. Soane, A.T. Bell and D.W. Hess, Transport models for swelling and dissolution of thin films, J. Appl. Polym. Sci. 38 (1989) 859-885.
17. B. Narasimhan and N.A. Peppas, On the importance of reptation in models of dissolution of glassy polymers, Macromolecules 29 (1996) 3283-3291.
18. J.D. Hoffman, Numerical Methods for Engineers and Scientists, McGraw-Hill, New York, 1992.
19. N.A. Peppas and E.W. Merrill, Poly(vinyl alcohol) hydrogels: Reinforcement of radiation-crosslinked networks by crystallization, J. Polym. Sci., Polym. Chem. 14 (1976) 441-457.
20. S.R. Lustig and N.A. Peppas, Solute diffusion in swollen membranes. IX. Scaling laws for solute diffusion in gels, J. Appl. Polym. Sci. 36 (1988) 735-747.