Involvement of 5-hydroxytryptamine (5-HT)3 receptor mechanisms in regulation of basal pancreatic secretion in conscious rats

Journal of the Autonomic Nervous System

Volumn 62, Issue 1-2, 1997, Pages 58-62

  Masuda, Masao ^a   Miyasaka, Kyoko ^a   Funakoshi, Akihiro ^b  

^a TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^b NATIONAL KYUSHU CANCER CENTER   (Japan)

Author keywords

5 HT3 receptor; Azasetron; Conscious rat; Enteropancreatic reflex; Pancreatic secretion

Indexed keywords

2 METHYLSEROTONIN; ATROPINE; AZASETRON; GRANISETRON; SEROTONIN 3 ANTAGONIST; SEROTONIN 3 RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; INTRAGASTRIC DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PANCREAS JUICE; PANCREAS SECRETION; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; TRUNCUS VAGOTOMY;

ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; DOSE-RESPONSE RELATIONSHIP, DRUG; GRANISETRON; MALE; OXAZINES; PANCREAS; RATS; RATS, WISTAR; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS;

EID: 0031036370     PISSN: 01651838     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1838(96)00109-9     Document Type: Article

References (19)

1. Andrew, P.L.R., Rapeport, W.G. and Sanger, G.J., Neuropharmacology of emesis induced by anti-cancer therapy, TIPS, 9 (1988) 334-341.
2. Bradley, P.B., Engel, G., Feniuk, W., Fozard, J.R., Humphrey, P.P.A., Middlemiss, D.N., Mylecharane. E.J., Rechardson, B.P. and Saxena, P.R., Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine, Neuropharmacology, 25 (1986) 563-576.
3. 3 receptor antagonist, Eur. J. Pharm., 196 (1991) 299-305.
4. Gershon, M.D., Localization and neurochemical aspects of serotonin in the gut, In T.S. Gaginella and J.J. Galligan (Eds.), Serotonin and gastrointestinal function, CRC press, London, 1996, pp. 11-31.
5. Guan, D., Spannagel, A., Ohta, H., Nakano. I., Chey, W.Y. and Green, G., Role of secretin in basal and fat-stimulated pancreatic secretion in conscious rats, Endocrinology, 128 (1991) 979-982.
6. Keller, P.J., Cohen, E. and Neurath, H., The proteins of bovine pancreatic juice, J. Biol. Chem., 233 (1958) 344-349.
7. Kirchgessner, A.L. and Gershon, M.D., Innervation of the pancreas by neurons in the gut, J. Neurosci., 10 (1990) 1626-1642.
8. Kirchgessner, A.L. and Gershon, M.D., Presynaptic inhibition by serotonin of nerve-mediated secretion of pancreatic amylase, Am. J. Physiol., 268 (1995) G339-G345.
9. Ma, R.C. and Szurszewski, J.H., 5-hydroxytryptamine depolarizes neurons of cat pancreatic ganglia, J. Auton. Nerv. Syst., 57 (1996) 78-86.
10. 2 analogue on pancreatic exocrine secretion in conscious rats, Pancreas, 10 (1995) 395-400.
11. Miyasaka, K. and Green, G., The effect of atropine on rat basal pancreatic secretion during return or diversion of bile pancreatic juice, Proc. Soc. Exp. Biol. Med., 174 (1983) 187-192.
12. Miyasaka, K., Funakoshi, A., Shikado, F. and Kitani, K., Stimulatory and inhibitory effects of bile salts on rat pancreatic secretion, Gastroenterology, 102 (1992) 598-604.
13. Miyasaka, K., Funakoshi, A., Kitani, K., Tamamura, H., Funakoshi, S. and Fujii, N., Inhibitory effect of pancreastatin on pancreatic exocrine secretions: pancreastatin inhibits central vagal nerve stimulation, Gastroemerology, 99 (1990) 1751-1756.
14. Miyasaka, K., Kitani, K. and Green, G.M., The sequential changes in pancreatic exocrine function after abdominal surgery in the rat. Pancreas, 1 (1986) 347-353.
15. 14C-Y-25130 after intravenous administration to rats, Yakubutsu Dotai, 7 (1992) 661-673 (in Japanese with English abstract).
16. Shiba, Y., Mizumoto, A., Satoh, M., Inui, A., Itoh, Z. and Omura, S., Effect of nonpeptide motilin agonist EM523 on release of gut and pancreatic hormones in conscious dogs, Gastroenterology, 110 (1996) 241-250.
17. Singer, M.V., Solomon, T.E., Wood, J. and Grossman, M.I., Latency of pancreatic enzyme response to intraduodenal stimulants, Am. J. Physiol., 238 (1980) G23-G29.
18. Singer, M.V., Neurohormonal control of pancreatic enzyme secretion in animals. In V.L.W. Go, E. Lebenthal, E.P. DiMagno, H.A. Reber, J.D. Gardner and G.A. Scheele (Eds.), The Pancreas, Raven Press, New York, 1993, pp. 425-448.
19. Sjölund, K., Sandén, G., Håkanson, R. and Sundler, F., Endocrine cells in human intestine: An immunocytochemical study, Gastroenterology, 85 (1983) 1120-1130.