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Volumn 16, Issue 3, 1997, Pages 588-598

Concerted evolution of the tandemly repeated genes encoding human U2 snRNA (the RNU2 locus) involves rapid intrachromosomal homogenization and rare interchromosomal gene conversion

Author keywords

Concerted evolution; Human genetic diversity; Linkage disequilibrium; Multigene family; Recombination

Indexed keywords

MICROSATELLITE DNA; SMALL NUCLEAR RNA;

EID: 0031033604     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.3.588     Document Type: Article
Times cited : (72)

References (60)
  • 1
    • 9044243028 scopus 로고    scopus 로고
    • Minisatellite diversity supports a recent African origin for modern humans
    • Armour, J.A.L. et al. (1996) Minisatellite diversity supports a recent African origin for modern humans. Nature Genet., 13, 154-160.
    • (1996) Nature Genet. , vol.13 , pp. 154-160
    • Armour, J.A.L.1
  • 2
    • 0019132475 scopus 로고
    • Molecular evidence for genetic exchanges among ribosomal genes on non-homologous chromosomes in man and apes
    • Arnheim, N., Krystal, M., Schmickel, R., Wilson, G., Ryder, O. and Zimmer, E. (1980) Molecular evidence for genetic exchanges among ribosomal genes on non-homologous chromosomes in man and apes Proc. Natl Acad. Sci. USA, 77, 7323-7327.
    • (1980) Proc. Natl Acad. Sci. USA , vol.77 , pp. 7323-7327
    • Arnheim, N.1    Krystal, M.2    Schmickel, R.3    Wilson, G.4    Ryder, O.5    Zimmer, E.6
  • 3
    • 0028786921 scopus 로고
    • Adenovirus type 12-induced fragility of the human RNU2 locus requires U2 small nuclear RNA transcriptional regulatory elements
    • Bailey, A.D., Li, Z., Pavelitz, T. and Weiner, A.M. (1995) Adenovirus type 12-induced fragility of the human RNU2 locus requires U2 small nuclear RNA transcriptional regulatory elements. Mol. Cell. Biol., 15, 6246-6255.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 6246-6255
    • Bailey, A.D.1    Li, Z.2    Pavelitz, T.3    Weiner, A.M.4
  • 4
    • 0028238234 scopus 로고
    • Complex recombination events at the hypervariable minisatellite CEB1 (D2S90)
    • Buard, J. and Vergnaud, G. (1994) Complex recombination events at the hypervariable minisatellite CEB1 (D2S90). EMBO J., 13, 3203-3210.
    • (1994) EMBO J. , vol.13 , pp. 3203-3210
    • Buard, J.1    Vergnaud, G.2
  • 5
    • 0028108183 scopus 로고
    • The evolutionary dynamics of repetitive DNA in eukaryotes
    • Charlesworth, B., Sniegowski, P. and Stephan, W. (1994) The evolutionary dynamics of repetitive DNA in eukaryotes. Nature, 371, 215-220.
    • (1994) Nature , vol.371 , pp. 215-220
    • Charlesworth, B.1    Sniegowski, P.2    Stephan, W.3
  • 6
    • 0020527088 scopus 로고
    • Unequal exchanges and the coevolution of X and Y rDNA arrays in D.melanogaster
    • Coen, E.S. and Dover, G.A. (1983) Unequal exchanges and the coevolution of X and Y rDNA arrays in D.melanogaster. Cell, 33, 849-855.
    • (1983) Cell , vol.33 , pp. 849-855
    • Coen, E.S.1    Dover, G.A.2
  • 8
    • 13344259999 scopus 로고    scopus 로고
    • A comprehensive genetic map of the human genome based on 5,264 microsatellites
    • Dib, C. et al. (1996) A comprehensive genetic map of the human genome based on 5,264 microsatellites. Nature, 380, 152-154.
    • (1996) Nature , vol.380 , pp. 152-154
    • Dib, C.1
  • 9
    • 0020478245 scopus 로고
    • Molecular drive, a cohesive mode of species evolution
    • Dover, G.A. (1982) Molecular drive, a cohesive mode of species evolution. Nature, 299, 111-117.
    • (1982) Nature , vol.299 , pp. 111-117
    • Dover, G.A.1
  • 10
    • 0027729030 scopus 로고
    • Detection and quantification of concerted evolution and molecular drive
    • Dover, G.A., Linares, A.R., Bowen, T. and Hancock, J.M. (1993) Detection and quantification of concerted evolution and molecular drive. Methods Enzymol., 224, 525-541.
    • (1993) Methods Enzymol. , vol.224 , pp. 525-541
    • Dover, G.A.1    Linares, A.R.2    Bowen, T.3    Hancock, J.M.4
  • 11
    • 0029360612 scopus 로고
    • Concerted evolution of repetitive DNA sequences in eukaryotes
    • Elder, J.F., Jr and Turner, B.J. (1995) Concerted evolution of repetitive DNA sequences in eukaryotes. Q. Rev. Biol., 70, 297-320.
    • (1995) Q. Rev. Biol. , vol.70 , pp. 297-320
    • Elder Jr., J.F.1    Turner, B.J.2
  • 12
    • 0029880961 scopus 로고    scopus 로고
    • Gene conversion plays the major role in controlling the stability of large tandem repeats in yeast
    • Gangloff, S., Zou, H. and Rothstein, R. (1996) Gene conversion plays the major role in controlling the stability of large tandem repeats in yeast EMBO J., 15, 1715-1725.
    • (1996) EMBO J. , vol.15 , pp. 1715-1725
    • Gangloff, S.1    Zou, H.2    Rothstein, R.3
  • 13
    • 0028784797 scopus 로고
    • The transcriptionally competent U2 gene is necessary and sufficient for adenovirus type 12 induction of the fragile site at 17q21-22
    • Gargano, S., Wang, P., Rusanganwa, E. and Bacchetti, S. (1995) The transcriptionally competent U2 gene is necessary and sufficient for adenovirus type 12 induction of the fragile site at 17q21-22. Mol. Cell. Biol., 15, 6256-6261.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 6256-6261
    • Gargano, S.1    Wang, P.2    Rusanganwa, E.3    Bacchetti, S.4
  • 14
    • 0023614553 scopus 로고
    • Induction of sister chromatid exchanges at common fragile sites
    • Glover, T.W. and Stein, C.K. (1987) Induction of sister chromatid exchanges at common fragile sites. Am. J. Hum. Genet., 41, 882-890.
    • (1987) Am. J. Hum. Genet. , vol.41 , pp. 882-890
    • Glover, T.W.1    Stein, C.K.2
  • 17
    • 0021724230 scopus 로고
    • Genes and pseudogenes for human U2 RNA. Implications for the mechanism of pseudogene formation
    • Hammarstrøm, K., Westin, G., Bark, C., Zabielski, J. and Pettersson, U. (1984) Genes and pseudogenes for human U2 RNA. Implications for the mechanism of pseudogene formation. J. Mol. Biol., 179, 157-169.
    • (1984) J. Mol. Biol. , vol.179 , pp. 157-169
    • Hammarstrøm, K.1    Westin, G.2    Bark, C.3    Zabielski, J.4    Pettersson, U.5
  • 18
    • 0025875852 scopus 로고
    • Sequence identity in an early chorion multigene family is the result of localized gene conversion
    • Hibner, B.L., Burke, W.D. and Eickbush, T.H. (1991) Sequence identity in an early chorion multigene family is the result of localized gene conversion. Genetics, 128, 595-606.
    • (1991) Genetics , vol.128 , pp. 595-606
    • Hibner, B.L.1    Burke, W.D.2    Eickbush, T.H.3
  • 19
    • 0026063996 scopus 로고
    • Evidence for biased gene conversion in concerted evolution of ribosomal DNA
    • Hillis, D.M., Moritz, C., Porter, C.A. and Baker, R.J. (1991) Evidence for biased gene conversion in concerted evolution of ribosomal DNA Science, 251, 308-310.
    • (1991) Science , vol.251 , pp. 308-310
    • Hillis, D.M.1    Moritz, C.2    Porter, C.A.3    Baker, R.J.4
  • 20
    • 0022102214 scopus 로고
    • Nuclease S1-sensitive sites in multigene families, human U2 small nuclear RNA genes
    • Htun, H., Lund, E., Westin, G., Pettersson, U. and Dahlberg, J.E. (1985) Nuclease S1-sensitive sites in multigene families, human U2 small nuclear RNA genes. EMBO J., 4, 1839-1845.
    • (1985) EMBO J. , vol.4 , pp. 1839-1845
    • Htun, H.1    Lund, E.2    Westin, G.3    Pettersson, U.4    Dahlberg, J.E.5
  • 21
    • 0021979069 scopus 로고
    • Hypervariable 'minisatellite' regions in human DNA
    • Jeffreys, A.J., Wilson, V. and Thein, S.L. (1985) Hypervariable 'minisatellite' regions in human DNA. Nature, 314, 67-73.
    • (1985) Nature , vol.314 , pp. 67-73
    • Jeffreys, A.J.1    Wilson, V.2    Thein, S.L.3
  • 23
    • 0027729645 scopus 로고
    • Experimental determination of rates of concerted evolution
    • Jinks-Robertson, S. and Petes, T.D. (1993) Experimental determination of rates of concerted evolution. Methods Enzymol., 224, 631-646.
    • (1993) Methods Enzymol. , vol.224 , pp. 631-646
    • Jinks-Robertson, S.1    Petes, T.D.2
  • 24
    • 0026709385 scopus 로고
    • Sister chromatids are preferred over homologs as substrates for recombinational repair in Saccharomyces cerevisiae
    • Kadyk, L.C. and Hartwell, L.H. (1992) Sister chromatids are preferred over homologs as substrates for recombinational repair in Saccharomyces cerevisiae. Genetics, 132, 387-402.
    • (1992) Genetics , vol.132 , pp. 387-402
    • Kadyk, L.C.1    Hartwell, L.H.2
  • 25
    • 0027509706 scopus 로고
    • Replication-dependent sister chromatid recombination in rad1 mutants of Saccharomyces cerevisiae
    • Kadyk, L.C. and Hartwell, L.H. (1993) Replication-dependent sister chromatid recombination in rad1 mutants of Saccharomyces cerevisiae. Genetics, 133, 469-487.
    • (1993) Genetics , vol.133 , pp. 469-487
    • Kadyk, L.C.1    Hartwell, L.H.2
  • 26
    • 0029610843 scopus 로고
    • Concerted evolution of the tandemly repeated genes encoding primate U2 small nuclear RNA (the RNU2 locus) does not prevent rapid diversification of the (CT)n·(GA)n microsatellite embedded within the U2 repeat unit
    • Liao, D. and Weiner, A.M. (1995) Concerted evolution of the tandemly repeated genes encoding primate U2 small nuclear RNA (the RNU2 locus) does not prevent rapid diversification of the (CT)n·(GA)n microsatellite embedded within the U2 repeat unit. Genomics, 30, 583-593.
    • (1995) Genomics , vol.30 , pp. 583-593
    • Liao, D.1    Weiner, A.M.2
  • 27
    • 0021986881 scopus 로고
    • Human genes for U2 small nuclear RNa map to a major adenovirus 12 modification site on chromosome 17
    • Lindgren, V., Ares, M., Weiner, A.M. and Francke, U. (1985) Human genes for U2 small nuclear RNA map to a major adenovirus 12 modification site on chromosome 17. Nature, 314, 115-116.
    • (1985) Nature , vol.314 , pp. 115-116
    • Lindgren, V.1    Ares, M.2    Weiner, A.M.3    Francke, U.4
  • 28
    • 0027420692 scopus 로고
    • A sister-strand exchange mechanism for recA-independent deletion of repeated DNA sequences in Escherichia coli
    • Lovett, S.T., Drapkin, P.T., Sutera, V.A., Jr and Gluckman-Peskind, T.J. (1993) A sister-strand exchange mechanism for recA-independent deletion of repeated DNA sequences in Escherichia coli. Genetics, 135, 431-642.
    • (1993) Genetics , vol.135 , pp. 431-642
    • Lovett, S.T.1    Drapkin, P.T.2    Sutera Jr., V.A.3    Gluckman-Peskind, T.J.4
  • 29
    • 0021968278 scopus 로고
    • U1 small nuclear RNA genes are subject to dosage compensation in mouse cells
    • Mangin, M., Ares, M., Jr and Weiner, A.M. (1985) U1 small nuclear RNA genes are subject to dosage compensation in mouse cells. Science, 229, 272-275.
    • (1985) Science , vol.229 , pp. 272-275
    • Mangin, M.1    Ares Jr., M.2    Weiner, A.M.3
  • 30
    • 0025014009 scopus 로고
    • Structure and evolution of the U2 snRNA multigene family in primates, gene amplification under natural selection
    • Matera, G., Weiner, A.M. and Schmid, C. (1990) Structure and evolution of the U2 snRNA multigene family in primates, gene amplification under natural selection. Mol. Cell. Biol., 10, 5876-5882.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 5876-5882
    • Matera, G.1    Weiner, A.M.2    Schmid, C.3
  • 31
    • 0029887819 scopus 로고    scopus 로고
    • Transcription-coupled repair deficiency and mutations in human mismatch repair genes
    • Mellon, I., Rajpal, D.K., Koi, M., Boland, C.R. and Champe, G.N. (1996) Transcription-coupled repair deficiency and mutations in human mismatch repair genes. Science, 272, 557-560.
    • (1996) Science , vol.272 , pp. 557-560
    • Mellon, I.1    Rajpal, D.K.2    Koi, M.3    Boland, C.R.4    Champe, G.N.5
  • 32
    • 0026764183 scopus 로고
    • High-frequency germ line gene conversion in transgenic mice
    • Murti, J.A., Bumbulis, M. and Schimenti, J.C. (1992) High-frequency germ line gene conversion in transgenic mice. Mol. Cell. Biol., 12, 2545-2552.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 2545-2552
    • Murti, J.A.1    Bumbulis, M.2    Schimenti, J.C.3
  • 33
    • 0028338678 scopus 로고
    • Gene conversion between unlinked sequences in the germline of mice
    • Murti, J.A., Bumbulis, M. and Schimenti, J.C. (1994) Gene conversion between unlinked sequences in the germline of mice. Genetics, 137, 837-843.
    • (1994) Genetics , vol.137 , pp. 837-843
    • Murti, J.A.1    Bumbulis, M.2    Schimenti, J.C.3
  • 34
    • 0029417008 scopus 로고
    • Precise spatial positioning of chromosomes during prometaphase, evidence for chromosome order
    • Nagele, R., Freeman, T., McMorrow, L. and Lee, H.-y. (1995) Precise spatial positioning of chromosomes during prometaphase, evidence for chromosome order. Science, 270, 1831-1835.
    • (1995) Science , vol.270 , pp. 1831-1835
    • Nagele, R.1    Freeman, T.2    McMorrow, L.3    Lee, H.-Y.4
  • 35
    • 0346840489 scopus 로고
    • Evolution of multigene families under interchromosomal gene conversion
    • Nagylaki, T. (1984) Evolution of multigene families under interchromosomal gene conversion. Proc. Natl Acad. Sci. USA, 81, 3796-3800.
    • (1984) Proc. Natl Acad. Sci. USA , vol.81 , pp. 3796-3800
    • Nagylaki, T.1
  • 36
    • 0020470241 scopus 로고
    • Intrachromosomal gene conversion and the maintenance of sequence homogeneity among repeated genes
    • Nagylaki, T. and Petes, T.D. (1982) Intrachromosomal gene conversion and the maintenance of sequence homogeneity among repeated genes. Genetics, 100, 315-337.
    • (1982) Genetics , vol.100 , pp. 315-337
    • Nagylaki, T.1    Petes, T.D.2
  • 37
    • 0027937794 scopus 로고
    • A P1-based physical map of the region from D17S776 to D17S78 containing the breast cancer susceptibility gene BRCA1
    • Neuhausen, S.L. et al. (1994) A P1-based physical map of the region from D17S776 to D17S78 containing the breast cancer susceptibility gene BRCA1. Hum. Mol. Genet., 3, 1919-1926.
    • (1994) Hum. Mol. Genet. , vol.3 , pp. 1919-1926
    • Neuhausen, S.L.1
  • 38
    • 0017296777 scopus 로고
    • Simple model for treating evolution of multigene families
    • Ohta, T. (1976) Simple model for treating evolution of multigene families. Nature, 262, 74-76.
    • (1976) Nature , vol.262 , pp. 74-76
    • Ohta, T.1
  • 39
    • 0020790321 scopus 로고
    • Population genetics of multigene families that are dispersed into two or more chromosomes
    • Ohta, T. and Dover, G.A. (1983) Population genetics of multigene families that are dispersed into two or more chromosomes. Proc. Natl Acad. Sci. USA, 80, 4079-4083.
    • (1983) Proc. Natl Acad. Sci. USA , vol.80 , pp. 4079-4083
    • Ohta, T.1    Dover, G.A.2
  • 40
    • 0026030088 scopus 로고
    • A unique pathway of double-strand break repair operates in tandemly repeated genes
    • Ozenberger, B.A. and Roeder, G.S. (1991) A unique pathway of double-strand break repair operates in tandemly repeated genes. Mol. Cell. Biol., 11, 1222-1231.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 1222-1231
    • Ozenberger, B.A.1    Roeder, G.S.2
  • 41
    • 0027137935 scopus 로고
    • + tumor cells
    • + tumor cells. Cell, 75, 1227-1236.
    • (1993) Cell , vol.75 , pp. 1227-1236
    • Parsons, R.1
  • 42
    • 0028893777 scopus 로고
    • Concerted evolution of the tandem array encoding primate U2 snRNA occurs in situ, without changing the cytological context of the RNU2 locus
    • Pavelitz, T., Rusché, L., Matera, A.G., Scharf, J.M. and Weiner, A.M. (1995) Concerted evolution of the tandem array encoding primate U2 snRNA occurs in situ, without changing the cytological context of the RNU2 locus. EMBO J., 14, 169-177.
    • (1995) EMBO J. , vol.14 , pp. 169-177
    • Pavelitz, T.1    Rusché, L.2    Matera, A.G.3    Scharf, J.M.4    Weiner, A.M.5
  • 43
    • 0018817106 scopus 로고
    • Molecular genetics of yeast
    • Petes, T.D. (1980) Molecular genetics of yeast. Annu. Rev. Biochem., 49, 845-876.
    • (1980) Annu. Rev. Biochem. , vol.49 , pp. 845-876
    • Petes, T.D.1
  • 44
    • 0029098957 scopus 로고
    • The yeast MER2 gene is required for chromosome synapsis and the initiation of meiotic recombination
    • Rockmill, B., Engebrecht, J.A., Scherthan, H., Loidl, J. and Roeder, G.S. (1995) The yeast MER2 gene is required for chromosome synapsis and the initiation of meiotic recombination. Genetics, 141, 49-59.
    • (1995) Genetics , vol.141 , pp. 49-59
    • Rockmill, B.1    Engebrecht, J.A.2    Scherthan, H.3    Loidl, J.4    Roeder, G.S.5
  • 45
    • 0026542473 scopus 로고
    • Slippage synthesis of simple sequence DNA
    • Schlötterer, C. and Tautz, D. (1992) Slippage synthesis of simple sequence DNA. Nucleic Acids Res., 20, 211-215.
    • (1992) Nucleic Acids Res. , vol.20 , pp. 211-215
    • Schlötterer, C.1    Tautz, D.2
  • 46
    • 0028500562 scopus 로고
    • Chromosomal homogeneity of Drosophila ribosomal DNA arrays suggests intrachromosomal exchanges drive concerted evolution
    • Schlötterer, C. and Tautz, D. (1994) Chromosomal homogeneity of Drosophila ribosomal DNA arrays suggests intrachromosomal exchanges drive concerted evolution. Curr. Biol., 4, 777-783.
    • (1994) Curr. Biol. , vol.4 , pp. 777-783
    • Schlötterer, C.1    Tautz, D.2
  • 47
    • 0023812871 scopus 로고
    • Linkage disequilibrium in human ribosomal genes, implications for multigene family evolution
    • Seperack, P. Slatkin, M. and Arnheim, N. (1988) Linkage disequilibrium in human ribosomal genes, implications for multigene family evolution. Genetics, 119, 943-949.
    • (1988) Genetics , vol.119 , pp. 943-949
    • Seperack, P.1    Slatkin, M.2    Arnheim, N.3
  • 49
    • 0029160045 scopus 로고
    • Interchromosomal recombination is suppressed in mammalian somatic cells
    • Shulman, M.J., Collins, C., Connor, A., Read, L.R. and Baker, M.D. (1995) Interchromosomal recombination is suppressed in mammalian somatic cells. EMBO J., 14, 4102-4107.
    • (1995) EMBO J. , vol.14 , pp. 4102-4107
    • Shulman, M.J.1    Collins, C.2    Connor, A.3    Read, L.R.4    Baker, M.D.5
  • 50
    • 0017294484 scopus 로고
    • Evolution of repeated DNA sequences by unequal crossover
    • Smith, G.P. (1976) Evolution of repeated DNA sequences by unequal crossover. Science, 191, 528-535.
    • (1976) Science , vol.191 , pp. 528-535
    • Smith, G.P.1
  • 51
    • 0025861706 scopus 로고
    • Characterization of human 5S rRNA genes
    • Sorensen, P.D. and Frederiksen, S. (1991) Characterization of human 5S rRNA genes. Nucleic Acids Res., 19, 4147-4151.
    • (1991) Nucleic Acids Res. , vol.19 , pp. 4147-4151
    • Sorensen, P.D.1    Frederiksen, S.2
  • 52
    • 0018869075 scopus 로고
    • Unequal crossing over in the ribosomal DNA of Saccharomyces cerevisiae
    • Szostak, J.W. and Wu, R. (1980) Unequal crossing over in the ribosomal DNA of Saccharomyces cerevisiae. Nature, 284, 426-430.
    • (1980) Nature , vol.284 , pp. 426-430
    • Szostak, J.W.1    Wu, R.2
  • 53
    • 0028605991 scopus 로고
    • A transposable element can drive the concerted evolution of tandemly repetitious DNA
    • Thompson-Stewart, D., Karpen, G.H. and Spradling, A.C. (1994) A transposable element can drive the concerted evolution of tandemly repetitious DNA. Proc. Natl Acad. Sci. USA, 91, 9042-9046.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 9042-9046
    • Thompson-Stewart, D.1    Karpen, G.H.2    Spradling, A.C.3
  • 54
    • 0029667388 scopus 로고    scopus 로고
    • Global patterns of linkage disequilibrium at the CD4 locus and modern human origins
    • Tishkoff, S.A. et al. (1996) Global patterns of linkage disequilibrium at the CD4 locus and modern human origins. Science, 271, 1380-1387.
    • (1996) Science , vol.271 , pp. 1380-1387
    • Tishkoff, S.A.1
  • 55
    • 0021359291 scopus 로고
    • Human genes for U2 small nuclear RNA are tandemly repeated
    • Van Arsdell, S.W. and Weiner, A.M. (1984) Human genes for U2 small nuclear RNA are tandemly repeated. Mol. Cell. Biol., 4, 492-499.
    • (1984) Mol. Cell. Biol. , vol.4 , pp. 492-499
    • Van Arsdell, S.W.1    Weiner, A.M.2
  • 56
    • 0023297258 scopus 로고
    • Persistence of tandem arrays: Implications for satellite and simple sequence DNAs
    • Walsh, J.B. (1987) Persistence of tandem arrays: implications for satellite and simple sequence DNAs. Genetics, 115, 553-567.
    • (1987) Genetics , vol.115 , pp. 553-567
    • Walsh, J.B.1
  • 57
    • 0029564979 scopus 로고
    • Interhomologue sequence variation of alpha satellite DNA from human chromosome 17, evidence for concerted evolution along haplotypic lineages
    • Warburton, P.E. and Willard, H.F. (1995) Interhomologue sequence variation of alpha satellite DNA from human chromosome 17, evidence for concerted evolution along haplotypic lineages. J. Mol. Evol., 41, 1006-1015.
    • (1995) J. Mol. Evol. , vol.41 , pp. 1006-1015
    • Warburton, P.E.1    Willard, H.F.2
  • 58
    • 0020262317 scopus 로고
    • Either gene amplification or gene conversion may maintain the homogeneity of the multigene family encoding human U1 small nuclear RNA
    • Weiner, A.M. and Denison, R.A. (1983) Either gene amplification or gene conversion may maintain the homogeneity of the multigene family encoding human U1 small nuclear RNA. Cold Spring Harbor Symp. Quant. Biol., 47, 1141-1149.
    • (1983) Cold Spring Harbor Symp. Quant. Biol. , vol.47 , pp. 1141-1149
    • Weiner, A.M.1    Denison, R.A.2
  • 59
    • 0025203702 scopus 로고
    • Centromeres of mammalian chromosomes
    • Willard, H.F. (1990) Centromeres of mammalian chromosomes. Trends Genet., 6, 410-416.
    • (1990) Trends Genet. , vol.6 , pp. 410-416
    • Willard, H.F.1
  • 60
    • 0024711426 scopus 로고
    • Unequal crossingover between homologous chromosomes is not the major mechanism involved in the generation of new alleles at VNTR loci
    • Wolff, R.K., Plaetke, R., Jeffreys, A.J. and White, R. (1989) Unequal crossingover between homologous chromosomes is not the major mechanism involved in the generation of new alleles at VNTR loci. Genomics, 5, 382-384.
    • (1989) Genomics , vol.5 , pp. 382-384
    • Wolff, R.K.1    Plaetke, R.2    Jeffreys, A.J.3    White, R.4


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