Phospholipase A2-induced cytoprotection of proximal tubules: Potential determinants and specificity for ATP depletion-mediated injury

Journal of the American Society of Nephrology

Volumn 7, Issue 1, 1996, Pages 64-72

  Zager, R A ^a   Burkhart, K M ^b   Conrad, D S ^b   Gmur, D J ^b   Iwata, M ^b  

^a USA   (United States)

^b NONE

Author keywords

A23187; Amphotericin B; Arachidonic acid; Cytochalasin D; Oxidant stress

Indexed keywords

2 (4 AMYLCINNAMIDO) 4 CHLOROBENZOIC ACID; ADENOSINE TRIPHOSPHATE; AMPHOTERICIN B; ANTIMYCIN A1; ARACHIDONIC ACID; CALCIMYCIN; CALCIUM IONOPHORE; CYTOCHALASIN D; FERROUS SULFATE; OUABAIN; PHOSPHOLIPASE A2; LACTATE DEHYDROGENASE; PHOSPHOLIPASE A;

ANIMAL TISSUE; ARTICLE; CELL PROTECTION; KIDNEY PROXIMAL TUBULE; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; ANIMAL; ANOXIA; DRUG EFFECT; IN VITRO STUDY; METABOLISM; PATHOLOGY;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANOXIA; ANTIMYCIN A; KIDNEY TUBULES, PROXIMAL; L-LACTATE DEHYDROGENASE; MALE; MICE; PHOSPHOLIPASES A;

EID: 0029661827     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1681/asn.v7164     Document Type: Article

References (33)

1. Weinberg JM: The cell biology of ischemic renal injury. Kidney Int 1991;39:476-500.
2. Bonventre JV: Mechanisms of ischemic acute renal failure. Kidney Int 1993;43:1160-1178.
3. 2 in hypoxic injury to rabbit proximal tubules. J Clin Invest 1994;93:1609-1615.
4. 2 activation in rabbit renal proximal tubules. Am J Physiol 1992;262:F354-F360.
5. Mathys E, Patel Y, Kreisberg J, Stewart JH, Venkatachalam M: Lipid alterations induced by renal ischemia: Pathogenic factor in membrane damage. Kidney Int 1984;26:153-161.
6. Humes HD, Nguyen VD, Cieslinski DA, Messana JM: The role of free fatty acids in hypoxla-induced injury to renal proximal tubule cells. Am J Physiol 1989;256: F688-F696.
7. Zager RA, Gmur DJ, Bredl CR, Eng MJ: Temperature effects on ischemic and hypoxic renal proximal tubular injury. Lab Invest 1991;64:766-776.
8. 2 enzymatic activity after renal ischemia and reperfusion. J Clin Invest 1991; 87:1810-1818.
9. 2-induced rabbit renal proximal tubule cell injury. J Clin Invest 1988;82:1098-1105.
10. 2-induced injury in rat proximal tubules. Am J Physiol 1993;264:F94-F99.
11. 2+ uptake, fatty acid, and LDH release during proximal tubule hypoxia: Effects of mepacrine and dibucaine. Am J Physiol 1994;266:F196-F201.
12. 2 can protect renal tubules from oxygen deprivation injury. Proc Natl Acad Sci USA 1993;90:8297-8301.
13. 2 deprivation injury, possibly by inducing uremia. Kidney Int 1994;45:1760-1768.
14. Zager RA, Bredl CR, Schimpf BA: Direct amphotericin B-mediated tubular toxicity: Assessments of selected cytoprotective agents. Kidney Int 1994;41:1588-1594.
15. Zager RA, Foerder CA: Effects of inorganic iron and myoglobin on in vitro proximal tubular lipid peroxidation and cytotoxicity. J Clin Invest 1992;89:989-995.
16. Zager RA, Burkhart KM, Conrad DS, Gmur DJ: Iron, heme oxygenase, and glutathione: Effects on myohemoglobinuric proximal tubular injury. Kidney Int 1995;48: 1624-1634.
17. Kroshian VM, Sheridan AM, Lieberthal W: Functional and cytoskeletal changes induced by sublethal injury in proximal tubular epithelial cells. Am J Physiol 1994;266: F21-F30.
18. - channels in human embryonic skeletal muscle cells. Pflugers Arch 1994;428:323-330.
19. Weinberg JM, Davis JA, Abarzua M, Smith RK, Kunkel R: Ouabain-induced lethal proximal tubule injury is prevented by glycine. Am J Physiol 1990;258:F346-F355.
20. Molitoris BA: New insights into the cell biology of ischemic acute renal failure. J Am Soc Nephrol 1991;1:1263-1270.
21. Molitoris BA: Ischemia-induced loss of epithelial polarity: Role of the actin cytoskeleton. Am J Physiol 1991; 260:F769-F778.
22. Molitoris BA, Dahl R, Geerdes A: Cytoskeletal disruption and apical redistribution of proximal tubule Na,K-ATPase during ischemia. Am J Physiol 1992;263:F488-F495.
23. Sawaya BP, Weihprecht H, Campbell WR, et al.: Direct vasoconstriction as a possible cause for amphotericin B-induced nephrotoxicity in rats. J Clin Invest 1991;87: 2097-2107.
24. Andreoli TE, Monahan M: The interaction of polyene antibiotics with thin lipid membranes. J Gen Physiol 1968;52:300-325.
25. Capasso G, Schuetz B, Vickermann B, Kinne R: Amphotericin B and amphotericin B methylester: Effect on brush border membrane permeability. Kidney Int 1986; 30:311-317.
26. Alkhunaizi AM, Edelstein CL, Yaqoob MM, et al.: Unsaturated fatty acids protect against hypoxia induced injury in rat proximal tubular epithelial cells [Abstract]. J Invest Med 1995;43:352A.
27. Bamga HS, Simons ER, Brass LF, Rittenhouse SE: Activation of phospholipase A and C in human platelets exposed to epinephrine: Role of glycoproteins IIb/IIIa and dual role of epinephrine. Proc Natl Acad Sci USA 1986;83:9197-9201.
28. 2+ oscillations in pancreatic acini. Biochem Biophys Res Commun 1993;194:1194-1202.
29. 2 inhibitor ONO-RS-082 on substance P-induced histamine release from rat peritoneal mass cells. Int Arch Allergy Immunol 1992;97:26-28.
30. Nakashima S, Suganuma A, Sato M, Tohmatsu T, Nozawa Y: Mechanism of arachidonic acid liberation in platelet-activating factor-stimulated human polymorphonuclear neutrophils. J Immunol 1989;143:1295-1302.
31. Sun JZ, Tang XL, Knowlton AA, Park SW, Qui Y, Bolli R: Late preconditioning against myocardial stunning. An endogenous protective mechanism that confers resistance to postischemic dysfunction 24 hours after brief ischemia in conscious pigs. J Clin Invest 1995;95:388-403.
32. Dmaison L, Grynberg A: Cellular and mitocnondrial energy metabolism in the stunned myocardium. Basic Res Cardiol 1994;89:293-307.
33. Zager RA, Baltes LA, Sharma HH, Jurkowitz MS: Responses of the ischemic acute renal failure kidney to additional ischemic events. Kidney Int 1984;26:689-700.