Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide

Journal of Experimental Medicine

Volumn 174, Issue 4, 1991, Pages 761-767

  Kwon, Nyoun Soo ^a   Stuehr, Dennis J ^a,b   Nathan, Carl F ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYUREA; NITRIC OXIDE; RIBONUCLEOTIDE REDUCTASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOSTASIS; DNA SYNTHESIS; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR CELL;

AMINO ACID OXIDOREDUCTASES; ANIMAL; ARGININE; CELL LINE; COPPER; COPPER SULFATE; FERREDOXINS; HYDROXYUREA; INTERFERON TYPE II; KINETICS; LEUKEMIA L1210; MACROPHAGES; MASS FRAGMENTOGRAPHY; MICE; NITRIC OXIDE; NITRIC-OXIDE SYNTHASE; NITRITES; RIBONUCLEOTIDE REDUCTASES; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0025938548     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.174.4.761     Document Type: Article

References (44)

1. D.J. Marietta and M.A. Marietta. 1985. Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide. Proc Natl. Acad. Sci. USA. 82:7738.
2. Hibbs, J.B., Jr., R.R. Taintor, and Z. Vavrin. 1987. Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite. Science (Wish. DC). 235:473.
3. Stuehr, D.J., and M.A. Marietta. 1987. Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lym-phokines, or interferon-7. J. Immunol. 139:518.
4. Ding, A.H., C.F. Nathan, and D.J. Stuehr. 1988. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages: comparison of activating cytokines and evidence for independent production. J. Immunol. 141:2407.
5. Marietta, M.A., P.S. Yoon, R. Iyengar, C.D. Leaf, and J.S. Wishnok. 1988. Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate. Biochemistry. 27:8706.
6. Hibbs, J.B., Jr., R.R. Taintor, Z. Vavrin, and E.M. Rachlin. 1988. Nitric oxide: a cytotoxic activated macrophage effector molecule. Biochem. Biophys. Res. Commun. 157:87.
7. Stuehr, D.J., S.S. Gross, I. Sakuma, R. Levi, and C.F. Nathan. 1989. Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide. J. Exp Med. 169:1011.
8. Stuehr, D.J., and C.F. Nathan. 1989. Nitric oxide: a macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells. J. Exp Med. 169:1543.
9. Nathan, C.F., and J.B. Hibbs, Jr. 1991. Role of nitric oxide synthesis in macrophage antimicrobial activity. Curr. Opinion Immunol. 3:65.
10. Granger, D.L., and A.L. Lehninger. 1982. Sites of inhibition of mitochondrial electron transport in macrophage-injured neoplastic cells. J. Cell Biol. 95:527.
11. Drapier, J.-C., and J.B. Hibbs, Jr. 1986. Murine cytotoxic activated macrophages inhibit aconitase in tumor cells: inhibition involves the iron-sulfur prosthetic group and is reversible. J. Clin. Invest. 78:790.
12. Hibbs, J.B., Jr., R.R. Taintor, and Z. Vavrin. 1984. Iron depletion: possible cause of tumor cell cytotoxicity induced by activated macrophages. Biochem. Biophys. Res. Commun. 123:716.
13. McDonald, C.C., W.D. Phillips, and H.F. Mower. 1965. An electron spin resonance study of some complexes of iron, nitric oxide, and anionic ligands. J. Am. Chem. Soc. 87:3319.
14. Ignarro, L.J., and C.A. Gruetter. 1980. Requirement of thiols for activation of coronary arterial guanylate cyclase by glyceryl trinitrate and sodium nitrite: possible involvement of S-nitro-sothiols. Biochim. Biophys. Acta. 631:221.
15. Pellat, C., Y. Henry, and J.-C. Drapier. 1990. IFN-y-activated macrophages: detection by electron paramagnetic resonance of complexes between L-arginine-derived nitric oxide and nonheme iron proteins. Biochem. Biophys. Res. Commun. 166:119.
16. Lancaster, J.R., Jr., and J.B. Hibbs, Jr. 1990. EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages. Proc. Natl. Acad. Sci. USA. 87:1223.
17. Stubbe, J. 1990. Ribonucleotide reductases: amazing and confusing. J. Biol. Chem. 265:5329.
18. Holmgren, A. 1989. Thioredoxin and glutaredoxin systems. J. Biol. Chem. 264:13963.
19. Reichard, P., and A. Ehrenberg. 1983. Ribonucleotide reductase: a radical enzyme. Science (Wash. DC). 221:514.
20. Ochiai, E.-I., G.J. Mann, A. Graslund, andL. Thelander. 1990. Tyrosyl free radical formation in the small subunit of mouse ribonucleotide reductase. J. Biol. Chem. 265:15758.
21. Nakagawara, A., and C.F. Nathan. 1983. A simple method for counting adherent cells: application to cultured human monocytes, macrophages and multinucleated giant cells./. Immunol. Methods. 56:261.
22. Graslund, A., A. Ehrenberg, and L. Thelander. 1982. Characterization of the free radical of mammalian ribonucleotide reductase. J. Biol. Chem. 257:5711.
23. Stuehr, D.J., N.S. Kwon, S.S. Gross, B.A. Thiel, R. Levi, and C.F. Nathan. 1989. Synthesis of nitrogen oxides from L-arginine by macrophage cytosol: requirement for inducible and constitutive components. Biochem. Biophys. Res. Commun. 161:420.
24. Bradford, M.M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248.
25. Kwon, N.S., C.F. Nathan, and D.J. Stuehr. 1989. Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages. J. Biol. Chem. 264:20496.
26. Stuehr, D.J., N.S. Kwon, and C.F. Nathan. 1990. FAD and GSH participate in macrophage synthesis of nitric oxide. Biochem. Biophys. Res. Commun. 168:558.
27. Moore, E.C. 1967. Mammalian ribonucleoside diphosphate reductases. Methods Enzymol. 12:155.
28. Steeper, J.R., and C.D. Steuart. 1970. A rapid assay for CDP reductase activity in mammalian cell extracts. Anal. Biochem. 34:123.
29. Cory, J.G., and G.L. Carter. 1988. Leukemia L1210 cell lines resistant to ribonucleotide reductase inhibitors. Cancer Res. 48:839.
30. Corg, J.G., M.M. Mansell, C.B. George, and D.S. Wilkinson. 1974. Inhibition of nucleic acid synthesis in Ehrlich tumor cells by periodate-oxidized adenosine and adenylic acid. Arch. Biochem. Biophys. 160:495.
31. 15N]nitrate in biological fluids. Anal. Biochem. 126:131.
32. Iyengar, R., D.J. Stuehr, and M.A. Marietta. 1987. Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst. Proc. Natl. Acad. Sci. USA. 84:6369.
33. Stuehr, D.J., O.A. Fasehun, N.S. Kwon, S.S. Gross, J.A. Gonzalez, R. Levi, and C.F. Nathan. 1991. Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs. FASEB (Fed. Am. Soc Exp Biol.) J. 5:98.
34. G-methylarginine. Biochem. Biophys. Res. Commun. 170:96.
35. Stuehr, D.J., N.S. Kwon, C.F. Nathan, O.W. Griffith, P.L. Feldman, and J. Wiseman. 1991. N“-Hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine. J. Biol. Chem. 266:6259.
36. Kosaka, H., J.S. Wishnok, M. Miwa, C.D. Leaf, and S.R. Tannenbaum. 1989. Nitrosation by stimulated macrophages: inhibitors, enhancers and substrates. Carcinogenesis. 10:563.
37. Reichard, P. 1988. Interactions between deoxyribonucleotide and DNA synthesis. Annu. Rev. Biochem. 57:349.
38. Lagergren, J., and P. Reichard. 1987. Purine deoxyribonucleo-sides counteract effects of hydroxyurea on deoxyribonucleo-side triphosphate pools and DNA synthesis. Biochem. Pharmacol. 36:2985.
39. Crawford, C.R., C.Y.C. Ng, L.D. Noel, and J.A. Belt. 1990. Nucleotide transport in L1210 murine leukemia cells: evidence for three transporters. J. Biol. Chem. 265:9732.
40. Fontecave, M., R. Eliasson, and P. Reichard. 1989. Enzymatic regulation of the radical content of the small subunit of Escherichia coli ribonucleotide reductase involving reduction of its redox centers. J. Biol. Chem. 264:9164.
41. Fontecave, M., C. Gerez, D. Mansuy, and P. Reichard. 1990. Reduction of the Fe(III)-tyrosyl radical center of Escherichia coli ribonucleotide reductase by dithiothreitol. J. Biol. Chem. 265:10919.
42. Lepoivre, M., B. Chenais, A. Yapo, G. Lemaire, L. Thelander, and J.-P. Tenu. 1990. Alterations of ribonucleotide reductase activity following induction of the nitrite-generating pathway in adenocarcinoma cells. J. Biol. Chem. 265:14143.
43. Adamson, R.H. 1972. Hydroxyguanidine: a new antitumour drug. Nature (Lond.). 236:400.
44. Tai, A.W., E.J. Lien, E.C. Moore, Y. Chun, and J.D. Roberts. 1983. Studies of N-hydroxy-N'-aminoguanidine derivatives by nitrogen-15 nuclear magnetic resonance spectroscopy and as ribonucleotide reductase inhibitors. J. Med. Chem. 26:1326