Inflammatory cytokines cause coronary arteriosclerosis-like changes and alterations in the smooth-muscle phenotypes in pigs

Journal of Cardiovascular Pharmacology

Volumn 29, Issue 2, 1997, Pages 222-231

  Fukumoto, Yoshihiro ^a   Shimokawa, Hiroaki ^a   Ito, Akira ^a   Kadokami, Toshiaki ^a   Yonemitsu, Yoshikazu ^a   Aikawa, Masanori ^b   Owada, M Koji ^c   Egashira, Kensuke ^a   Sueishi, Katsuo ^a   Nagai, Ryozo ^b   Yazaki, Yoshio ^b   Takeshita, Akira ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Atherosclerosis; Cytokines; Interleukin 1 ; Interleukin 1 ; Tumor necrosis factor

Indexed keywords

INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ARTERY CONSTRICTION; ARTERY INTIMA PROLIFERATION; ARTICLE; ATHEROGENESIS; CELL DIFFERENTIATION; CORONARY ARTERY ATHEROSCLEROSIS; IMMUNOPATHOGENESIS; IMMUNOREGULATION; MALE; NONHUMAN; PRIORITY JOURNAL; SWINE; VASCULAR SMOOTH MUSCLE;

ANIMALS; CORONARY ARTERIOSCLEROSIS; CORONARY VESSELS; INTERLEUKIN-1; MALE; MUSCLE, SMOOTH, VASCULAR; MYOSIN HEAVY CHAINS; PHENOTYPE; SWINE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0031030303     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199702000-00011     Document Type: Article

References (35)

1. Munro JM, Cotran RS. Biology of disease: the pathogenesis of atherosclerosis: atherogenesis and inflammation. Lab Invest 1988;58: 249-61.
2. Hannson GK, Jonasson L, Seifert PS, Stemme S. Immune mechanisms in atherosclerosis. Arteriosclerosis 1989;9:567-78.
3. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 1993;362:801-9.
4. Shimokawa H, Tomoike H, Nabeyama S, et al. Coronary artery spasm induced in atherosclerotic miniature swine. Science 1983; 221:560-2.
5. Shimokawa H, Tomoike H, Nabeyama S, et al. Coronary artery spasm induced in miniature swine: angiographic evidence and relation to coronary atherosclerosis. Am Heart J 1985;110:300-10.
6. Egashira K, Tomoike H, Yamamoto Y, Yamada A, Hayashi Y, Nakamura M. Histamine-induced coronary spasm in regions of intimal thickening in miniature pigs: roles of serum cholesterol and spontaneous or induced intimal thickening. Circulation 1986;74:826-37.
7. Libby P, Warner SJC, Friedman G. Interleukin 1: a mitogen for human vascular smooth muscle cells that induces the release of growth-inhibitory prostanoids. J Clin Invest 1988;81:487-98.
8. Ikeda U, Ikeda M, Oohara T, Kano S, Yaginuma T. Mitogenic action of interleukin-1α on vascular smooth muscle cells mediated by PDGF. Atherosclerosis 1990;84:183-8.
9. Shimokawa H, Ito A, Fukumoto Y, et al. Chronic treatment with interleukin-1β induces coronary intimal lesions and vasospastic responses in pigs in vivo: the role of platelet-derived growth factor. J Clin Invest 1996;97:769-76.
10. Ito A, Shimokawa H, Kadokami T, et al. Tyrosine kinase inhibitor suppresses coronary arteriosclerotic changes and vasospastic responses induced by chronic treatment with interleukin-1β in pigs in vivo. J Clin Invest 1995;96:1288-94.
11. Old LJ. Tumor necrosis factor (TNF). Science 1985;230:630-2.
12. Aikawa M, Palanisamy N, Kuro-o M, et al. Human smooth muscle myosin heavy chain isoforms as molecular markers for vascular development and atherosclerosis. Circ Res 1993;73:1000-12.
13. Nakano K, Abe S, Sohmura Y. Recombinant human tumor necrosis factor. I. Cytototoxic activity in vitro. Int J Immunopharmacol 1986;8:347-55.
14. Kita M, Ohmoto Y, Hirai Y, Yamaguchi N, Imanishi J. Induction of cytokines in human peripheral blood mononuclear cells by mycoplasmas. Microbiol Immunol 1992;36:507-16.
15. Hsu SM, Raine L, Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques. J Histochem Cytochem 1981;29:577-80.
16. Kuro-o M, Nagai R, Nakahara K, et al. cDNA cloning of a myosin heavy chain isoform in embryonic smooth muscle and its expression during vascular development and in arteriosclerosis. J Biol Chem 1991;266:3768-73.
17. Kawamoto S, Adelstein RS. Chicken nonmuscle myosin heavy chains: differential expression of two mRNAs and evidence for two different polypeptides. J Cell Biol 1991;112:915-24.
18. Simons M, Wang M, McBride OW, et al. Human nonmuscle myosin heavy chains are encoded by two genes located on different chromosomes. Circ Res 1991;69:530-9.
19. Bagby GC Jr. Interleukin-1 and hematopoiesis. Blood Rev 1989;3: 152-61.
20. Arai K, Lee F, Miyajima A, Miyatake S, Arai N, Yokota T. Cytokines: coordinators of immune and inflammatory responses. Annu Rev Biochem 1990;59:783-836.
21. Dinarello CA, Cannon JG, Wolff SM, et al. Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1. J Exp Med 1986;163:1433-50.
22. Gamble JR, Harlan JM, Klebanoff SJ, Vadas MA. Stimulation of the adherence of neutorophils to umbilical vein endothelium by human recombinant tumor necrosis factor. Proc Natl Acad Sci U S A 1985;82:8667-71.
23. McIntosh JK, Jablons DM, Mule JJ, et al. In vivo induction of IL-6 by administration of exogenous cytokines and detection of de novo serum levels of IL-6 in tumor-bearing mice. J Immunol 1989;143:162-7.
24. Wakefield PE, James WD, Samlaska CP, Meltzer MS. Tumor necrosis factor. J Am Acad Dermatol 1991;24:675-85.
25. Moyer CF, Sajuthi D, Tulli H, Williams JK. Synthesis of IL-1 alpha and IL-1 beta by arterial cells in atherosclerosis. Am J Pathol 1991;138:951-60.
26. Ito A, Shimokawa H, Fukumoto Y, et al. The role of fibroblast growth factor-2 in the vascular effects of interleukin-1β in porcine coronary arteries in vivo. Cardiovasc Res 1996;32:570-9.
27. Ito A, Shimokawa H, Nakaike R, et al. Role of protein kinase C-mediated pathway in the pathogenesis of coronary artery spasm in a swine model. Circulation 1994;90:2425-31.
28. Kadokami T, Shimokawa H, Fukumoto Y, et al. Coronary artery spasm does not depend on the intracellular calcium store but is substancially mediated by the protein kinase C-mediated pathway in a swine model with interleukin-1β in vivo. Circulation 1996;94:190-6.
29. Fukumoto Y, Shimokawa H, Kozai T, Ito A. Role of nitric oxide in coronary lesions induced by chronic treatment with interleukin-1β in pigs in vivo. Circulation 1995;92(suppl I):I-424.
30. Katsumata N, Shimokawa H, Kozai T, et al. Increased myosin light chain phosphorylations as a central mechanism for coronary artery spasm. Circulation 1995;94(suppl I):I-636.
31. Pauletto P, Chiavegato A, Giuriato L, et al. Hyperplastic growth of aortic smooth muscle cells in renovascular hypertensive rabbits is characterized by the expansion of an immature cell phenotype. Circ Res 1994;74:774-88.
32. Bai H, Masuda J, Sawa Y, et al. Neointima formation after vascular stem implantation: spatial and chronological distribution of smooth muscle cell proliferation and phenotypic modulation. Arterioscler Thromb 1994;14:1846-53.
33. Gabbiani G, Kocher O, Bloom WS. Actin expression in smooth muscle cells of rat aortic intimai thickening, human atheromatous plaque, and cultured rat aortic media. J Clin Invest 1984;73:148-52.
34. Owens GK, Loeb A, Gordon D, Thompson MM. Expression of smooth muscle-specific α-isoactin in cultured vascular smooth muscle cells: relationship between growth and cytodifferentiation. J Cell Biol 1986;102:343-52.
35. Kocher O, Gabbiani F, Gabbiani G, et al. Phenotypic features of smooth muscle cells during the evolution of experimental carotid artery intimal thickening: biochemical and morphologic studies. Lab Invest 1991;65:459-70.