A new non-random chromosomal translocation t(3;6)(q27;p21.3) associated with BCL6 rearrangement in two patients with non-Hodgkin's lymphoma

International Journal of Hematology

Volumn 64, Issue 3-4, 1996, Pages 249-256

  Miura, Ikuo ^a   Ohshima, Atsushi ^a   Takahashi, Naoto ^a   Hashimoto, Keiko ^a   Nimura, Takashi ^a   Utsumi, Seiko ^a   Saito, Masahiro ^a   Miki, Tohru ^b   Hirosawa, Shinsaku ^b   Miura, Akira B ^a  

^a AKITA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

3q27; BCL6; Non Hodgkin's lymphoma; t(3; 6)(q27; p21.3)

Indexed keywords

ONCOPROTEIN; PROTEIN BCL 6; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CASE REPORT; CHROMOSOME TRANSLOCATION 3; CHROMOSOME TRANSLOCATION 6; FEMALE; GENE REARRANGEMENT; HUMAN; HUMAN CELL; MALE; NONHODGKIN LYMPHOMA; PRIORITY JOURNAL;

EID: 0030273478     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1016/0925-5710(96)00496-3     Document Type: Article

References (19)

1. [1] Gaidano G, Dalla-Favera R. Oncogenes and tumor suppressor genes. In: Knowles DM. (ed). Neoplastic hematopathology. Baltimore: Wilkins & Wilkins, 1992;245-261.
2. [2] Bastard C, Tilly H, Lenormand B, Bigorgne C, Boulet D, Kunlin A, Monconduit M, Piguet H. Translocations involving band 3q27 and Ig gene regions in non-Hodgkin's lymphoma. Blood 1992;79:2527.
3. [3] Hashimoto K, Miura I, Chyubachi A, Saito M, Miura AB. Correlations of chromosome abnormalities with histologic and immunologic characteristics in 49 patients from Akita, Japan with non-Hodgkin's lymphoma. Caneer Genet Cytogenet 1995;81:56.
4. [4] LoCoco F, Ye BH, Lista F, Corradini P, Offit K, Knowles DM, Chaganti RSK, Dalla-Favera R. Rearrangements of BCL-6 gene in diffuse large cell non-Hodgkin's lymphoma. Blood 1994;83:1757.
5. [5] Bastard C, Deweindt C, Kerckaert JP, Lenormand B, Rossi A, Pezzella F, Fruchart C, Duval C, Monconduit M, Tilly H. LAZ3 rearrangements in non-Hodgkin's lymphoma with histology, immunophenotype, karyotype, and clinical outcome in 217 patients. Blood 1994;83:2423.
6. [6] Baron BW, Nucifora G, McCabe N, Espinosa III R, LeBeau MM, McKeithan TW. Identification of the gene associated with the recurring chromosomal translocations t(3;14)(q27;q32) and t(3;22)(q27:q11) in B-cell lymphomas. Proc Natl Acad Sci USA 1993;90:5262.
7. [7] Ye BH, Rao PH, Chaganti RSK, Dalla-Favera R. Cloning of bcl-6. the locus involved in chromosome translocalions affecting band 3q27 in B-cell lymphoma. Cancer Res 1993;53:2732.
8. [8] Kerckaert J-P, Deweindt C, Tilly H, Quief S, Lecocq G, Bastard C. LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas. Nature Genet 1993;5:66.
9. [9] Ye BH, Lista F, LoCoco F, Knowles DM, Offit K, Chaganti RSK, Dalla-Favera R. Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma. Science 1993;262:747.
10. [10] Deweindt C, Kerckaert J-P, Tilly H, Quief S, Nguyen VC, Bastard C. Cloning of a breakpoint cluster region at band 3q27 involved in human non-Hodgkin's lymphoma. Cancer 1993;8:149.
11. [11] Miki T, Arai A, Kawamata N, Ohashi K, Nakamura Y, Kato A, Hirosawa S, Aoki N. Molecular cloning of the breakpoint for 3q27 translocation in B-cell lymphomas and leukemias. Blood 1994;83:217.
12. [12] Miki T, Kawamata N, Hirosawa S, Aoki N. Gene involved in the 3q27 translocation associated with B-cell lymphoma. BCL-5, encodes a krüppel-like zinc-finger protein. Blood 1994;83:26.
13. [13] Offit K, LoCoco F, Louie DC, Parsa NZ, Leung D, Portlock C, Ye BH, Lista F, Filippa DA, Rosenbaum A, Ladanyi M, Jhanwar S, Dalla-Favera R, Chaganti RSK. Rearrangement of the bcl-6 gene as a prognostic marker in diffuse large-cell lymphoma. N Engl J Med 1994;331:74.
14. [14] ISCN (1991), Guideline for cancer cytogenetics, supplement to an international system for human cytogenetic nomenclature. Basel: S. Karger, 1991.
15. [15] Maniatis T, Fritsch EF, Sambrook J. Molecular cloning: a laboratory manual, 2nd edn. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 1989.
16. [16] Sandberg AA. The chromosomes in human cancer and leukemia, 2nd edn. New York: Elsevier, 1990.
17. [17] Kluin PM. bcl-6 in lymphoma - sorting out a wastebasket? N Engl J Med 1994;331:116.
18. [18] Ohno H, Kerckaert J-P, Bastard C, Fukuhara S. Heterogeneity in B-cell neoplasms associated with rearrangement of the LAZ3 gene on chromosome band 3q27. Jpn J Cancer Res 1994;85:592.
19. [19] Dallery E, Galiègue-Zouitina S, Collyn-dLantoine D, Deweindt C, Tilly H, Bastard C, Kerckaert J-P. TTF, a gene encoding a novel small G protein, fuses to the lymphoma associated LAZ3 gene by t(3;4) chromosomal translocation. Oncogene 1995;10:2171.