Lack of gonadotropin-positive feedback in the male rat is associated with lack of estrogen-induced synaptic plasticity in the arcuate nucleus

Neuroendocrinology

Volumn 65, Issue 2, 1997, Pages 136-140

  Horvath, Tamas L ^a   Garcia Segura, Luis Miguel ^b   Naftolin, Frederick ^a  

^a YALE UNIVERSITY   (United States)

^b INSTITUTO CAJAL   (Spain)

Author keywords

Arcuate nucleus; Castration; Feedback; Gonadal steroids; Gonadotropins; Synaptic plasticity

Indexed keywords

ESTRADIOL; ESTROGEN; GONADOTROPIN;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARCUATE NUCLEUS; ARTICLE; CASTRATION; CONTROLLED STUDY; ELECTRON MICROSCOPY; ESTRUS; FEEDBACK SYSTEM; FEMALE; GONADECTOMY; MALE; NERVE CELL PLASTICITY; NONHUMAN; OVARY CYCLE; POSITIVE FEEDBACK; PRIORITY JOURNAL; RAT;

ANIMALS; ARCUATE NUCLEUS; CASTRATION; ESTRADIOL; FEEDBACK; FEMALE; GONADOTROPINS; LUTEINIZING HORMONE; MALE; MICROSCOPY, ELECTRON; NEURONAL PLASTICITY; PROGESTERONE; RATS; RATS, WISTAR; SEX CHARACTERISTICS; SYNAPSES;

EID: 0031026864     PISSN: 00283835     EISSN: 14230194     Source Type: Journal    
DOI: 10.1159/000127173     Document Type: Article

References (19)

1. Horvath TL, Leedom L, Garcia-Segura LM, Naflolin F: Estrogcn-induced hypothalamic synaptic plasticity: Implications for the regulation of gonadotrophins, Curr Opin Endocrinol Diabetes 1995;2:186-190.
2. Garcia-Segura LM, Baetens D, Naftolin F: Synaptic remodeling in arcuate nucleus after injection of estradiol valerate in adult female rats, Brain Res 1986;36:131-136.
3. Garcia-Segura LM, Olmos G, Tranque P, Naftolin F: Rapid effects of gonadal steroids upon hypothalamic neuronal membrane ultrastructure, J Steroid Biochem 1987;27:615-623.
4. Garcia-Segura LM, Luquin S, Parducz A, Naftolin F: Gonadal hormone regulation of glial fibrillary acidic protein immunoreactivity and glial ultrastructure in the rat neuroendocrine hypothalamus, Glia 1994:10:59-69.
5. Olmos G, Naftolin F, Tranque P, Garcia-Scgu-ra LM: Synaptic remodeling in the rat arcuate nucleus during the cstrus cycle, Neuroscience 1989;32:663-667.
6. Matsumoto A, Arai Y: Synaptogcnic effect of estrogen on the hypothalamic arcuate nucleus of the adult female rat, Cell Tissue Res 1979; 198:427-433.
7. McEwen BS, Gould E, Orchinik M, Wciland NG, Wooley CS: Oestrogens and the structural and functional plasticity of neurons: Implications for memory, aging and neurodegenerative processes, Ciba Found Symp 1995:191:52-66.
8. Naftolin F, Mor G, Horvath TL, Luquin S, Faj-er A, Kohen F, Garcia-Segura LM: Synaptic plasticity in the hypothalamic arcuate nucleus during estrus cycle is induced by estrogen and precedes the preovulatory gonadotropin surge, Endocrinology 1996, in press.
9. Shivers BD, Harlan RE, Morell JI, Pfaff DW: Absence of ocstradiol concentration in cell nuclei of LHRH-immunoreactive neurons, Nature 1983;304:345-347.
10. Leranth C, MacLusky NJ, Shanabrough M, Naftolin F: Immunohistochemical evidence for synaptic connections between pro-opiomelano-cortin-immunorcactive axons and LH-RH neurons in the preoptic area of the rat, Brain Res 1988:449:167-176.
11. Perez J, Naftolin F, Garcia-Segura LM: Sexual differentiation of synaptic connectivity and neuronal plasma membrane in the arcuate nucleus of the rat hypothalamus, Brain Res 1990; 527:116-122.
12. Palkovits M: Guide and map for the isolated removal of individual cell groups from the rat brain, Akademia Kiado, Budapest 1980
13. Reymond M, Lemarchand-Beraud T: Differential effects of testosterone and its metabolites on gonadotrophin secretion in the intact adult male rat, Horm Res 1981; 14:114-129.
14. Paxinos G, Watson C: The Rat Brain in Stereotaxic Coordinates, ed 2, San Diego, Academic Press, 1986.
15. Wise PM, Weiland NG, Scarbrough K, Larson GH, Lloyd JM: Effect of aging on reproductive neuroendocrine function; in Naftolin F, Gut-mann JN, DeChemay AH, Sarrel PM (eds): Ovarian secretions and Cardiovascular and Neurological Function, Serono Symp, New York, Raven Press, 1990, vol 80, pp 287-296.
16. Garcia-Segura LM, Perez J, Jones E, Naftolin F: Loss of sexual dimorphism in rat arcuate nucleus neuronal membranes with reproductive aging, Exp Neurol 1991:112:125-128.
17. Brown TJ, Hochberg B, Naftolin F, MacLusky NJ: Pubertal development of estrogen receptors in the rat brain, Mol Cell Ncurosci 1995:5: 475-483.
18. Parducz A, Perez J, Garcia-Segura LM: Estradiol induces plasticity of GABAergic synapses in the hypothalamus, Neuroscience 1993;53: 395-401.
19. Lewis CE, Naftolin F: Morphological effects of estradiol valcrateon presynapticcatecholamin-ergic, and GABAergic nerve terminals (abstract 47.2), Annu Meet Soc Neurosci, Miami, 1994, p 100.