Synaptic remodeling in the arcuate nucleus during the estrous cycle is induced by estrogen and precedes the preovulatory gonadotropin surge

Endocrinology

Volumn 137, Issue 12, 1996, Pages 5576-5580

  Naftolin, F ^a,d   Mor, G ^b   Horvath, T L ^a   Luquin, S ^c   Fajer, A B ^b   Kohen, F ^b   Garcia Segura, L M ^c  

^a YALE UNIVERSITY   (United States)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^c INSTITUTO CAJAL   (Spain)

^d FMB 335 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIETHYLSTILBESTROL; ESTRADIOL; ESTRADIOL ANTIBODY; ESTROGEN; LUTEINIZING HORMONE; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; ESTROGEN ACTIVITY; ESTROGEN RELEASE; ESTRUS CYCLE; FEMALE; GONADOTROPIN RELEASE; HYPOTHALAMUS; LUTEINIZING HORMONE RELEASE; NERVE CELL PLASTICITY; NONHUMAN; OVULATION; POSITIVE FEEDBACK; PREGNANCY; PRIORITY JOURNAL; SYNAPSE;

EID: 0030459719     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.137.12.8940386     Document Type: Article

References (23)

1. Naftolin F, Brown-Grant K, Corker CS 1972 Plasma and pituitary luteinizing hormone and peripheral plasma oestradiol concentrations in the normal oestrus cycle of the rat and after experimental manipulation of the cycle. J Endocrinol 53:17-30
2. Harris GW, Naftolin F 1970 The hypothalamus and control of ovulation. Br Med Bull 26:3-9
3. Ferin M, Tempone A, Zimmering PE, Vande Wiele RL 1969 Effect of antibodies to 17β-estradiol and progesterone on the estrus cycle of the rat. Endocrinology 85:1070-1078
4. Kalra SP 1993 Mandatory neuropeptide-steroid signaling for the preovulatory luteinizing-releasing hormone discharge. Endocr Rev 14:507-538
5. Horvath TL, Leedom L, Garcia-Segura LM, Naftolin F 1995 Estrogen induced hypothalamic synaptic plastcity; Implications for the regulation of gonadotrophins. Curr Opin Endocrinol Diab 2:186-190
6. Olmos G, Naftolin F, Tranque P, Garcia-Segura LM 1989 Synaptic remodeling in the rat arcuate nucleus during the estrus cycle. Neuroscience 32:663-667
7. Kohler G, Milstein C 1976 Derivation of specific antibody-producing tissue culture and tumor lines by cell fusion. Eur J Immunol 6:511-522
8. Kohen F, Lichter S 1986 Monoclonal antibodies to steroid hormones. In: Forti G, Lipsett MB, Serio M (eds) Monoclonal Antibodies: Basic Principles, Experimental and Clinical Applications in Endocrinology. Raven Press, New York pp 87-95
9. Eshhar Z, Kohen F, Lindner HR 1982 Production of monoclonal antibodies to steroid hormones. In: Peeters H (ed) Proteins of the Biological Fluids, 29th Colloquium, 1981. Pergamon Press, Oxford and New York, pp 823-826
10. Raziano J, Ferin M, Vande Wiele RL 1972 Effects of antibodies to estradiol-17β and to progesterone on nidation and pregnancy in rats. Endocrinology 90:1133-1142
11. Garcia-Segura LM, Baetens D, Naftolin F 1986 Synaptic remodeling in arcuate nucleus after injection of estradiol valerate in adult female rats. Brain Res 36:131-136
12. Garcia-Segura LM, Olmos G, Tranque P, Naftolin F 1987 Rapid effects of gonadal steroids upon hypothalamic neuronal membrane ultrastructure. J Steroid Biochem 27:615-623
13. Knobil E, Hotchkiss J 1988 The menstrual cycle and its neuroendocrine control. In: Knobil E, Neill J (eds) The Physiology of Reproduction. Raven Press, New York, pp 1971-1944
14. Harris GW, Campbell HJ 1966 The regulation of secretion of luteinizing hormone and ovulation. In: Harris GW, Donovan BT (eds) The Pituitary Gland. Butterworth, London, vol 2:99-165
15. Odell WD, Ross GT, Rayford FL 1967 Radioimmunoassay for luteinizing hormone in human plasma or serum: physiological studies. J Clin Invest 46:248-255
16. Shaikh AA, Shaikh SA 1975 Adrenal and ovarian steroid secretion in the rat estrus cycle temporarily related to gonadotrophins and steroid levels found in peripherial plasma. Endocrinology 96:37-44
17. Sarkar DK, Chiappa SA, Fink G, Sherwood NM 1976 Gonadotropin-releasing hormone surge in pro-oestrus rats. Nature 264:461-463
18. Leranth C, MacLusky NJ, Shanabrough M, Naftolin F 1988 Immunohistochemical evidence for synaptic connections between pro-opiomelanocortin-immunoreactive axons and LH-RH neurons in the preoptic area of the rat. Brain Res 449:167-176
19. Horvath TL, Naftolin F, Leranth C 1992 GABAergic and catecholaminergic innervation of mediobasal hypothalamic β-endorphin cells projecting to the medial preoptic area. Neuroscience 51:391-399
20. Horvath TL, Naftolin F, Kalra SP, Leranth C 1992 Neuropeptide Y innervation of β-endorphin-containing cells in the rat mediobasal hypothalamus. A light and electron microscopic double-immunostaining study. Endocrinology 131:2461-2467
21. Parducz A, Perez J, Garcia-Segura LM 1993 Estradiol induces plasticity of GABAergic synapses in the hypothalamus. Neuroscience 53:395-401
22. Lewis CE, Naftolin F 1994 Morphological effects of estradiol valerate on presynaptic catecholaminergic, and GABAergic nerve terminals. Annual Meeting of Society for Neuroscience, Miami FL, p 100 (Abstract 47.2)
23. Horvath TL, Naftolin F 1996 Estradiol treatment increases the number of synapses targeting β-endorphin cells. 43nd Ann Meeting of the Society for Gynecologic Investigation, Philadelphia PA. J Soc Gynecol Invest 3:162 (Abstract 208)