Role of CD4 epitopes outside the gp120-binding site during entry of human immunodeficiency virus type 1

Journal of Virology

Volumn 71, Issue 2, 1997, Pages 1476-1484

  Simon, James H M ^a,c   Stumbles, Phil ^a,d   Signoret, Nathalie ^b   Somoza, Chamorro ^a,e   Puklavec, Mike ^a   Sattentau, Quentin J ^b   Barclay, A Neil ^a   James, William ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b CENTRE D IMMUNOLOGIE DE MARSEILLE LUMINY   (France)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^e MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; EPITOPE; GLYCOPROTEIN GP 120; IMMUNOGLOBULIN;

ARTICLE; BINDING SITE; CHIMERA; GENE EXPRESSION; GENE MUTATION; HUMAN IMMUNODEFICIENCY VIRUS 1; MUTAGENESIS; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; VIRUS VIRULENCE;

EID: 0031026218     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.2.1476-1484.1997     Document Type: Article

References (54)

1. Arthos, J., K. C. Deen, M. A. Chaikin, J. A. Fornwald, G. Sathe, Q. J. Sattentau, P. R. Clapham, R. A. Weiss, J. S. McDougal, C. Pietropaolo, R. Axel, A. Truneh, P. J. Maddon, and R. W. Sweet. 1989. Identification of the residues in human CD4 critical for the binding of HIV. Cell 57:469-481.
2. Ashkenazi, A., L. G. Presta, S. A. Marsters, T. R. Camerato, K. A. Rosenthal, B. M. Fendly, and D. J. Capon. 1990. Mapping the CD4 binding site for human immunodeficiency virus by alanine-scanning mutagenesis. Proc. Natl. Acad. Sci. USA 87:7150-7154.
3. Berger, E. A., J. D. Lifson, and L. E. Eiden. 1991. Stimulation of glycoprotein gp120 dissociation from the envelope glycoprotein complex of human immunodeficiency virus type 1 by soluble CD4 and CD4 peptide derivatives: implications for the role of the complementarity-determining region 3-like region in membrane fusion. Proc. Natl. Acad. Sci. USA 88:8082-8086.
4. Brady, R., E. Dodson, G. Dodson, G. Lange, S. Davis, A. F. Williams, and A. N. Barclay. 1993. Crystal structure of domains 3 and 4 of rat CD4: relation to the NH2-terminal domains. Science 260:979-983.
5. Broder, C. C., and E. A. Berger. 1993. CD4 molecules with a diversity of mutations encompassing the CDR3 region efficiently support human immunodeficiency virus type 1 envelope glycoprotein-mediated cell fusion. J. Virol. 67:913-926.
6. Brodsky, M. H., M. Warton, R. M. Myers, and D. R. Littman. 1990. Analysis of the site in CD4 that binds to the HIV envelope glycoprotein. J. Immunol. 144:3078-30786.
7. Burkly, L., D. Olson, R. Shapiro, G. Winkler, J. Rosa, D. Thomas, C. Williams, and P. Chisholm. 1992. Inhibition of infection by novel CD4 domain 2-specific monoclonal antibodies. J. Immunol. 149:1779-1787.
8. Camerini, D., and B. Seed. 1990. A CD4 domain important for HIV-mediated syncytium formation lies outside the virus binding site. Cell 60:747-754.
9. Choe, H., M. Farzan, Y. Sun, N. Sullivan, B. Rollins, P. D. Ponath, L. Wu, C. R. Mackay, G. LaRosa, W. Newman, N. Gerard, C. Gerard, and J. Sodroski. 1996. The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 85:1135-1148.
10. Clayton, L. K., R. E. Hussey, R. Sleinbrich, H. Ramachandran, Y. Husain, and E. L. Reinherz. 1988. Substitution of murine for human CD4 residues identifies amino acids critical for HIV-gp120 binding. Nature 335:363-366.
11. Collin, M., and S. Gordon. 1994. The kinetics of HIV reverse transcription are slower in primary human macrophages than in a lymphoid line. Virology 200:114-120.
12. Corbeau, P., M. Benkirane, R. Weil, C. David, S. Emiliani, D. Olive, C. Mawas, A. Serre, and C. Devaux. 1993. Ig CDR-3 like region of CD4 molecule is involved in syncytia formation but not in viral entry. J. Immunol. 150:290-301.
13. Dalgleish, A. G., P, C. L. Beverley, P. R. Clapham, D. H. Crawford, M. F. Greaves, and R. A. Weiss. 1984. The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature 312:736-766.
14. Davis, S., G. Schockmel, C. Somoza, D. Buck, D. Healey, E. Rieber, C. Reiter, and A. Williams. 1992. Antibody and HIV-1 gp120 recognition of CD4 undermines the concept of mimicry between antibodies and receptors. Nature 358:76-79.
15. Davis, S. J., R. L. Brady, A. N. Barclay, K. Harlos, G. G. Dodson, and A. F. Williams. 1990. Crystallization of a soluble form of the rat T-cell surface glycoprotein CD4 complexed with Fab from the W3/25 monoclonal antibody. J. Mol. Biol. 213:7-10.
16. Davis, S. J., H. A. Ward, M. J. Puklavec, A. C. Willis, A. F. Williams, and A. N. Barclay. 1990. High level expression in Chinese hamster ovary cells of soluble forms of CD4 T lymphocyte glycoprotein including glycosylation variants. J. Biol. Chem. 265:10410-10418.
17. Deng, H., R. Liu, W. Ellmeier, S. Choe, D. Unutmaz, M. Burkhart, P. Di Marzio, S. Marmon, R. E. Sutton, C. M. Hill. C. B. Davis, S. C. Peiper, T. J. Schall, D. R. Littman, and N. R. Landau. 1996. Identification of a major co-receptor for primary isolates of HIV-1. Nature 381:661-666.
18. Doranz, B. J., J. Rucker, Y. Yi, R. Smyth, M. Samson, S. C. Peiper, M. Parmentier, R. G. Collman, and R. W. Doms. 1996 A dual-tropic primary HIV-1 isolate that uses fusin and the β-chemokine receptors CKR-5, CKR-3 and CKR-2b as fusion cofactors. Cell 85:1149-1158.
19. Dragic, T., V. Litwin, G. P. Allaway, S. R. Martin, Y. Huang, K. A. Nagashima, C. Cayanan, P. J. Maddon, R. A. Koup, J. P. Moore, and W. A. Paxton, 1996. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature 381:667-673.
20. Feng, Y., C. C. Broder, P. E. Kennedy, and E. A. Berger. 1996. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 272:872-877.
21. Gey, G. O., W. D. Coffman, and M. T. Kubicek. 1952. Tissue culture studies of the proliferative capacity of cervical carcionoma and normal epithelium. Cancer Res. 12:264-265.
22. Golding, H., R. Blumenthal, J. Manischewitz, D. R. Littman, and D. S. Dimitrov. 1993. Cell fusion mediated by interaction of a hybrid CD4.CD8 molecule with the human immunodeficiency virus type 1 envelope glyeoprotein does occur after a long lag time. J. Virol. 67:6469-6475.
23. Hasunuma, T., H. Tsubota, M. Watanabe, Z. Chen, C. Lord, L. Burkly, J. Daley, and N. Letvin. 1992. Regions of the CD4 molecule not involved in virus binding or syncytia formation are required for HIV-1 infection of lymphocytes. J. Immunol. 148:1841-1846.
24. Healey, D., L. Dianda, J. P. Moore, J. S. McDougal, M. J. Moore, P. Estess, D. Buck, P. D. Kwong, P. C. L. Beverley, and Q. J. Sattentau. 1990. Novel anti-CD4 monoclonal antibodies separate human immunodeficiency virus infection and fusion of CD4+ cells from virus binding. J. Exp. Med. 172: 1233-1242.
25. Jonkers, A. H., R. E. Shope, T. H. G. Aitken, and L. Spence. 1964. Cocal virus, a new agent in Trinidad related to vesicular stomatitis virus, type Indiana. Am. J. Vet. Res. 25:236-241.
26. Kalyanaraman, V. S., D. M. Rausch, J. Osborne, M. Padgett, K. M. Hwang, J. D. Lifson, and L. E. Eiden. 1990. Evidence by peptide mapping that the region CD4(81-92) is involved in gp120/CD4 interaction leading to HIV infection and HIV-induced syncytium formation. J. Immunol. 145:4072-4078.
27. Klatzmann, D., E. Champagne, S. Chamaret, J. Gruest, D. Guetard, T. Hercend, J.-C. Gluckman, and L. Montagnier. 1984. T-lymphocyte T4 molecule behaves as the receptor for the human retrovirus LAV. Nature 312: 767-768.
28. Layne, S. P., M. J. Merges, M. Dembo, J. L. Spouge, and P. L. Nara. 1990. HIV requires multiple gp120 molecules for CD4-mediated infection. Nature 346:277-279:
29. Lifson, J. D., K. M. Hwang, P. L. Nara, B. Fraser, M. Padgett, N. M. Dunlop, and L. E. Eiden. 1988. Synthetic CD4 peptide derivatives that inhibit HIV infection and cytopathicity. Science 241:712-716.
30. Lifson, J. D., D. M. Rausch, V. S. Kalyanaraman, K. M. Hwang, and L. E. Eiden. 1991. Synthetic peptides allow discrimination of structural features of CD4(81-92) important for HIV-1 infection versus HIV-1-induced syncytium formation. AIDS Res. Hum. Retroviruses 7:521-527.
31. MacPherson, I. and M. Stoker. 1962. Polyoma transformation of hamster cell clones - an investigation of genetic factors affecting cell competence. Virology 16:147-151.
32. McDougal, J. S., J. K. Nicholson, G. D. Cross, S. P. Cort, M. S. Kennedy, and A. C. Mawle. 1986. Binding of the human retrovirus HTLV-III/LAV/ARV/ HIV to the CD4 (T4) molecule: conformation dependence, epitope mapping, antibody inhibition, and potential for idiotypic mimicry. J. Immunol. 137:2937-2944.
33. Moebius, U., L. Clayton, S. Abraham, S. Harrison, and E. Reinherz. 1992. The human immunodeficiency virus gp120 binding site on CD4: delineation by quantitative equilibrium and kinetic binding studies of mutants in conjunction with a high resolution CD4 atomic structure. J. Exp. Med. 176:507-517.
34. Moore, J. 1993. A monoclonal antibody to the CDR-3 region of CD4 inhibits sCD4 binding to virions of HIV-1. J. Virol. 67:3656-3659.
35. Moore, J. P., J. A. McKeating, W. A. Norton, and Q. J. Sattentau. 1991. Direct measurement of soluble CD4 binding to human immunodeficiency virus type 1 virions: gp120 dissociation and its implications for virus-cell binding and fusion reactions and their neutralization by soluble CD4. J Virol. 65:1133-1140.
36. Moore, J. P., J. A. McKeating, R. A. Weiss, and Q. J. Sattentau. 1990. Dissociation of gp120 from HIV-1 virions induced by soluble CD4. Science 250:1139-1142.
37. + cells. J. Virol. 66:4784-4793.
38. Nara, P. L., K. M. Hwang, D. M. Rausch, J. D. Lifson, and L. E. Eiden. 1989. CD4 antigen-based antireceptor peptides inhibit infectivity of human immunodeficiency virus in vitro at multiple stages of the viral life cycle. Proc. Natl. Acad. Sci. USA 86:7139-7143.
39. Peterson, A., and B. Seed. 1988. Genetic analysis of monoclonal antibody and HIV binding sites on the human lymphocyte antigen CD4. Cell. 54:65-72.
40. Popovic, M., M. G. Sarngadharan, E. Read, and R. C. Gallo. 1984. Detection, isolation and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS. Science 224:497-500.
41. Poulin, L., L. A. Evans, S. B. Tang, A. Barboza, H. Legg, D. R. Littman, and J. A. Levy. 1991. Several CD4 domains can play a role in human immunodeficiency virus infection in cells. J. Virol. 65:4893-4901.
42. Ratner, L., W. Haseltine, R. Patarca, K. J. Livak, B. Starcich, S. F. Josephs, E. R. Doran, J. A. Rafalski, E. A. Whitehorn, K. Baumeister, L. Ivanoff, S. R. Petteway, Jr., M. L. Pearson, J. A. Lautenberger, T. S. Papas, J. Ghrayeb, N. T. Chang, R. C. Gallo, and F. Wong-Staal. 1985. Complete nucleotide sequence of the AIDS virus, HTLV-III. Nature 313:277-284.
43. Repke, H., D. Gabuzda, G. Palu, F. Emmrich, and J. Sodroski. 1992. Effects of CD4 synthetic peptides on human immunodeficiency virus type I envelope glycoprotein function. J. Immunol. 148:1809-1846.
44. Robey, E., and R. Axel. 1990. CD4: collaborator in immune recognition and HIV infection. Cell 60:697-700.
45. Ryu, S. E., P. D. Kwong, A. Truneh, T. G. Porter, J. Arthos, M. Rosenberg, X. P. Dai, N. H. Xuong, R. Axel, R. W. Sweet, and W. A. Hendrickson. 1990. Crystal structure of an HIV-binding recombinant fragment of human CD4. Nature 348:419-426.
46. Salahuddin, S. Z., P. D. Markham, S. F. Wang, G. Franchini, V. S. Kalyanaraman, and R. C. Gallo. 1983. Restricted expression of human T-cell leukemia-lymphoma virus (HTLV) in transformed human umbilical cord blood lymphocytes. Virology 129:51-64.
47. Sattentau, Q. J., J. Arthos, K. Deen, N. Hanna, D. Healey, P. C. Beverley, R. Sweet, and A. Truneh. 1989. Structural analysis of the human immunodeficiency virus-binding domain of CD4. Epitope mapping with site-directed mutants and anti-idiotypes. J. Exp. Med. 170:1319-1334.
48. Sattentau, Q. J., and J. P. Moore. 1991. Conformational changes induced in the human immunodeficiency virus envelope glycoprotein by soluble CD4 binding. J. Exp. Med. 174:407-415.
49. Schockmel, G. A., C. Somoza, S. J. Davis, A. F. Williams, and D. Healey. 1992. Construction of a binding site for human immunodeficiency virus type 1 gp120 in rat CD4. J. Exp Med. 175:301-304.
50. Signoret, N., D. Blanc-Zouaoui, P. Kwong, and Q. J. Sattentau. 1996. Selective effects of electrostatic changes in the CD4-CDR-3-like loop on infection by different human immunodeficiency type 1 isolates. AIDS Res. Hum. Retroviruses 12:1001-1013.
51. Simon, J. H. M., C. Somoza, G. A. Schockmel, M. Collin, S. J. Davis, A. F. Williams, and W. James. 1993. A rat CD4 mutant containing the gp120-binding site mediates human immunodeficiency virus type 1 infection. J. Exp. Med. 177:949-954.
52. Truneh, A., D. Buck, D. R. Cassatt, R. Juszczak, S. Kassis, S. E. Ryu, D. Healey, R. Sweet, and Q. Sattentau. 1991. A region in domain 1 of CD4 distinct from the primary gp120 binding site is involved in HIV infection and virus-mediated fusion. J. Biol. Chem. 266:5942-5948.
53. Wang, J., Y. Van, T. P. J. Garrett, J. Liu, D. W. Rodgers, R. L. Garlick, G. E. Tarr, Y. Husain, E. L. Reinherz, and S. C. Harrison. 1990. Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains. Nature 348:411-419.
54. Williams, A. F., G. Galfre, and C. Milstein. 1977. Analysis of cell surfaces by xenogeneic myeloma-hybrid antibodies: differentiation antigens of rat lymphocytes. Cell 12:663-673.