Identification of amdX, a new Cys-2-His-2 (C2H2) zinc-finger gene involved in the regulation of the amdS gene of Aspergillus nidulans

Molecular Microbiology

Volumn 23, Issue 3, 1997, Pages 591-602

  Murphy, Rachael L ^b   Andrianopoulos, Alex ^a   Davis, Meryl A ^a   Hynes, Michael J ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ZINC FINGER PROTEIN;

ARTICLE; ASPERGILLUS NIDULANS; CONTROLLED STUDY; DNA BINDING; DNA SEQUENCE; GENE EXPRESSION REGULATION; NONHUMAN; PRIORITY JOURNAL; TRANSCRIPTION REGULATION;

EID: 0031025919     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.1997.d01-1872.x     Document Type: Article

References (48)

1. Adams, T.H., Boylan, M.T., and Timberlake, W.E. (1988) brlA is necessary and sufficient to direct conidiophore development in Aspergillus nidulans. Cell 54: 353-362.
2. Andrianopoulos, A., and Hynes, M.J. (1988) Cloning and analysis of the positively acting regulatory gene amdR from Aspergillus nidulans. Mol Cell Biol 8: 3532-3541.
3. Andrianopoulos, A., and Timberlake, W.E. (1994) The Aspergillus nidulans abaA gene encodes a transcriptional activator that acts as a genetic switch to control development. Mol Cell Biol 14: 2503-2515.
4. Armitt, S., McCullough, W., and Roberts, C.F. (1976) Analysis of acetate non-utilizing (acu) mutants in Aspergillus nidulans. J Gen Microbiol 92: 263-282.
5. Atkinson, P.W., King, J.A., and Hynes, M.J. (1985) Identification of the aciA gene controlled by the amdA regulatory gene in Aspergillus nidulans. Curr Genet 10: 133-138.
6. Ballance, D.J. (1986) Sequences important for gene expression in filamentous fungi. Yeast 2: 229-236.
7. Berg, J.M. (1992) Sp1 and the subfamily of zinc finger proteins with guanine-rich binding sites. Proc Natl Acad Sci USA 89: 11109-11110.
8. Chavrier, P., Lemaire, P., Relelant, O., Bravo, R., and Charney, P. (1988) Characterization of a mouse multigene family that encodes zinc finger structures. Mol Cell Biol 8: 1319-1326.
9. Christy, B., and Nathans, D. (1989) DNA binding site of the growth-factor-inducible protein Zif268. Proc Natl Acad Sci USA 86: 8737-8741.
10. Christy, B.A., Lau, L.F., and Nathans, D. (1988) A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with zinc finger sequences. Proc Natl Acad Sci USA 85: 7857-7861.
11. Clutterbuck, J.A. (1969) A mutational analysis of conidial development in Aspergillus nidulans. Genetics 63: 317-327.
12. Clutterbuck, J.A. (1974) Aspergillus nidulans genetics. In Handbook of Genetics, Vol. 1. King, R.C. (ed.). New York: Plenum Publishing Corp., pp. 447-510.
13. Cubero, B., and Scazzocchio, C. (1994) Two different, adjacent and divergent zinc finger binding sites are necessary for CREA-mediated carbon catabolite repression in the proline gene cluster of Aspergillus nidulans. EMBO J 13: 407-415.
14. Davis, M.A., Cobbett, C.S., and Hynes, M.J. (1988) An amdS-lacZ fusion for studying gene regulation in Aspergillus. Gene 63: 199-212.
15. Davis, M.A., Kelly, J.M., and Hynes, M.J. (1993) Fungal catabolic gene regulation: molecular genetic analysis of the amdS gene of Aspergillus nidulans. Genetica 90: 133-145.
16. Dobson, M.J., Tuite, M.F., Roberts, N.A., Kingsman, A.J., Kingsman, S.M., Perkins, R.E., Conroy, S.C., Dunbar, B., and Fothergill, L.A. (1982) Conservation of high efficiency promoter sequences in Saccharomyces cerevisiae. Nucleic Acids Res 10: 2625-2637.
17. Dowzer, C.E.A., and Kelly, J.M. (1991) Analysis of the creA gene, a regulator of carbon catabolite repression in Aspergillus nidulans. Mol Cell Biol 11: 5701-5709.
18. Espeso, E.A., and Peñalva, M.A. (1994) In vitro binding of the two-finger repressor CreA to several consensus and non-consensus sites at the ipnA upstream region is context dependent. FEBS Lett 342: 43-48.
19. Fairall, L., Schwabe, J.W.R., Chapman, L., Finch, J.T., and Rhodes, D. (1993) The crystal structure of a two zinc-finger peptide reveals an extension to the rules for zinc-finger/ DNA recognition. Nature 366: 483-487.
20. Ginsberg, A.M., King, B.O., and Roeder, R.G. (1984) Xenopus 5S gene transcription factor, TFIIIA: characterization of a cDNA clone and measurement of RNA levels throughout development. Cell 39: 479-489.
21. Gurr, S.J., Unkles, S.E., and Kinghorn, J.R. (1987) The structure and organization of nuclear genes of filamentous fungi. In Gene Structure in Eukaryotic Microbes. Kinghorn, J.R. (ed.). Oxford: IRL Press, pp. xx-xx.
22. Hartshorne, T.A., Blumberg, H., and Young, E.T. (1986) Sequence homology of the yeast regulatory protein ADR1 with Xenopus transcription factor TFIIIA. Nature 320: 283-287.
23. Hastie, A.C. (1970) Benlate-induced instability of Aspergillus diploids. Nature 226: 771.
24. Hynes, M.J. (1978) Multiple independent control mechanisms affecting the acetamidase of Aspergillus nidulans. Mol Gen Genet 161: 59-65.
25. Hynes, M.J. (1982) A cis-dominant mutation in Aspergillus nidulans affecting the expression of the amdS gene in the presence of mutations in the unlinked gene, amdA. Genetics 102: 139-147.
26. Hynes, M.J. (1994) Regulation of acetamide utilization. In Aspergillus; 50 Years On. Vol. 29. Martinelli, S.D., and Kinghorn, J.R. (eds). The Netherlands: Elsevier, pp. 279-397.
27. Hynes, M.J., Corrick, C.M., Kelly, J.M., and Littlejohn, T.G. (1988) Identification of the sites of action for regulatory genes controlling the amdS gene of Aspergillus nidulans. Mol Cell Biol 8: 2589-2596.
28. Käfer, E. (1961) The processes of spontaneous recombination in vegetative nuclei of Aspergillus nidulans. Genetics 45: 1581-1609.
29. Katz, M.E., and Hynes, M.J. (1989) Isolation and analysis of the acetate regulatory gene, facB, from Aspergillus nidulans. Mol Cell Biol 9: 5696-5701.
30. Katz, M.E., Saleeba, J.E., Sapats, S.I., and Hynes, M.J. (1990) A mutation affecting amdS expression in Aspergillus nidulans contains a triplication of a cis-acting regulatory sequence. Mol Gen Genet 220: 373-376.
31. Kulmburg, P., Mathieu, M., Dowzer, C., Kelly, J., and Felenbok, B. (1993) Specific binding sites in the alcR and alcA promoters of the ethanol regulon for the CREA repressor mediating carbon catabolite repression in Aspergillus nidulans. Mol Microbiol 7: 847-857.
32. Lints, R., Davis, M.A., and Hynes, M.J. (1995) The positively acting amdA gene of Aspergillus nidulans encodes a protein with two C2H2 zinc-finger motifs. Mol Microbiol 15: 965-975.
33. Littlejohn, T.G., and Hynes, M.J. (1992) Analysis of the site of action of the amdR product for regulation of the amdS gene of Aspergillus nidulans. Mol Gen Genet 235: 81-88.
34. Lundin, M., Nehlin, J.O., and Ronne, H. (1994) Importance of a flanking AT-rich region in target site recognition by the GC box-binding zinc finger protein MIG1. Mol Cell Biol 14: 1979-1985.
35. Marck, C. (1988) 'DNA Strider': a 'C' program for fast analysis of DNA and protein sequences on the Apple Macintosh family of computers. Nucleic Acids Res 16: 1829-1836.
36. Mathieu, M., and Felenbok, B. (1994) The Aspergillus nidulans CREA protein mediates glucose repression of the ethanol regulon at various levels through competition with the ALCR-specific transactivator. EMBO J 13: 4022-4027.
37. Morelle, G. (1989) A plasmid extraction procedure on a mini-prep scale. Focus 11: 7-8.
38. Oakley, C.E., Weil, C.F., Kretz, P.L., and Oakley, B.R. (1987) Cloning of the riboB locus of Aspergillus nidulans. Gene 53: 293-298.
39. Pavletich, N.P., and Pabo, C.O. (1991) Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 Å. Science 252: 809-817.
40. Pavletich, N.P., and Pabo, C.O. (1993) Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers. Science 261: 1701-1707.
41. Robbins, J., Dilworth, S.M., Laskey, R.A., and Dingwall, C. (1991) Two interdependent basic domains in the nucleoplasmin nuclear targeting sequence: identification of a class of bipartite nuclear targeting sequence. Cell 64: 615-623.
42. Roper, J.A. (1952) Production of heterozygous diploids in filamentous fungi. Experientia 8: 14-15.
43. Saleeba, J.A., Cobbett, C.S., and Hynes, M.J. (1992) Characterization of the amdA-regulated aciA gene of Aspergillus nidulans. Mol Gen Genet 235: 349-358.
44. Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual. 2nd edn. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press.
45. Sealy Lewis, H.M. (1990) The identification of mutations in Aspergillus nidulans that lead to increased level of ADHII. Curr Genet 18: 65-70.
46. Thompson, J.D., Higgins, D.G., and Gibson, T.J. (1994) CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position specific gap penalties and weight matrix choice. Nucleic Acids Res 22: 4673-4680.
47. Tilburn, J., Sarkar, S., Widdick, D.A., Espeso, E.A., Orejas, M., Mungroo, J., Peñalva, M., and Arst, Jr, H.N. (1995) The Aspergillus PacC zinc finger transcription factor mediates regulation of both acid- and alkaline-expressed genes by ambient pH. EMBO J 14: 779-790.
48. Todd, R.B., Murphy, R.L., Martin, H.M., Sharp, J.A., Davis, M.A., Katz, M.E., and Hynes, M.J. (1997) The acetate regulatory gene facB of Aspergillus nidulans encodes a Zn(II)Cys6 transcriptional activator. Mol Gen Genet, in press.