The acetate regulatory gene facB of Aspergillus nidulans encodes a Zn(II)2Cys6 transcriptional activator

Molecular and General Genetics

Volumn 254, Issue 5, 1997, Pages 495-504

  Todd, R B ^a   Murphy, R L ^b   Martin, H M ^c   Sharp, J A ^c   Davis, M A ^c   Katz, M E ^d   Hynes, M J ^c  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d UNIVERSITY OF NEW ENGLAND   (Australia)

Author keywords

(C6 zinc) binuclear cluster; Acetate metabolism; Aspergillus; facB; Gene regulation; Zn(II)2cys6

Indexed keywords

ACETAMIDE; ACETIC ACID; CARBON; DNA BINDING PROTEIN; LEUCINE ZIPPER PROTEIN; REPETITIVE DNA; TRANSACTIVATOR PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; ASPERGILLUS NIDULANS; CARBON DIOXIDE FIXATION; CARBOXY TERMINAL SEQUENCE; FUNGAL GENETICS; GENE DELETION; METABOLISM; NONHUMAN; PRIORITY JOURNAL; REGULATOR GENE; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION;

ACETATES; AMINO ACID SEQUENCE; ASPERGILLUS NIDULANS; BASE SEQUENCE; CONSERVED SEQUENCE; CYSTEINE; DNA-BINDING PROTEINS; FUNGAL PROTEINS; GENES, BACTERIAL; GENES, REGULATOR; GENETIC COMPLEMENTATION TEST; LEUCINE ZIPPERS; MOLECULAR SEQUENCE DATA; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID; TRANS-ACTIVATORS; ZINC;

ASPERGILLUS; ASPERGILLUS NIGER; ASPERGILLUS ORYZAE; EMERICELLA NIDULANS; SACCHAROMYCES CEREVISIAE;

EID: 0030998445     PISSN: 00268925     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004380050444     Document Type: Article

References (59)

1. Andrianopoulos A, Hynes MJ (1988) Cloning and analysis of the positively acting regulatory gene amdR from Aspergillus nidulans. Mol Cell Biol 8:3532-3541
2. Andrianopoulos A, Hynes MJ (1990) Sequence and functional analysis of the positively acting regulatory gene amdR from Aspergillus nidulans. Mol Cell Biol 10:3194-3203
3. Apirion D (1965) The two-way selection of mutants and revertants in respect of acetate utilization and resistance to fluoro-acetate in Aspergillus nidulans. Genet Res 6:317-329
4. Armitt S, McCullough W, Roberts CF (1976) Analysis of acetate non-utilising (acu) mutants in Aspergillus nidulans. J Gen Microbiol 92:263-282
5. Austin B, Hall RM, Tyler BM (1990) Optimized vectors and selection for transformation of Neurospora crassa and Aspergillus nidulans to bleomycin and phleomycin resistance. Gene 93:157-162
6. Bai Y, Kohlhaw GB (1991) Manipulation of the 'zinc cluster' region of transcriptional activator LEU3 by site directed mutagenesis. Nucleic Acids Res 19:5991-5997
7. Ballance DJ, Turner G (1986) Gene cloning in Aspergillus nidulans: isolation of the isocitrate lyase gene (acuD). Mol Gen Genet 202:271-275
8. Chasman DI, Kornberg RD (1990) GAL4 protein: purification, association with GAL80 protein, and conserved domain structure. Mol Cell Biol 10:2916-2923
9. Clutterbuck AJ (1974) Aspergillus nidulans genetics. In: King RC (ed) Handbook of genetics, vol I. Plenum Press, New York, pp 447-510
10. Cohen C, Parry DAD (1990) α-helical coiled coils and bundles: how to design an α-helical protein. Proteins 7:1-15
11. Cooernaert D, Vissers S, André B (1991) The pleiotropic UGA35 (DURL) regulatory gene of Saccharomyces cerevisiae: cloning, sequence and identity with the DAL81 gene. Gene 97:163-171
12. Cove DJ (1966) The induction and repression of nitrate reductase in the fungus Aspergillus nidulans. Biochim Biophys Acta 133:51-56
13. Cress WD, Triezenberg SJ (1991) Critical structural elements of the VP16 transcriptional activation domain. Science 251:87-90
14. Davis MA, Cobbett CS, Hynes MJ (1988) An amdS-lacZ fusion for studying gene regulation in Aspergillus. Gene 63:199-212
15. Defranoux N, Gaisne M, Verdière J (1994) Functional analysis of the zinc cluster domain of the CYPI (HAP1) complex regulator in heme-sufficient and heme-deficient cells. Mol Gen Genet 242:699-707
16. Durrens P, Green PM, Arst HN, Scazzocchio C (1986) Heterologous insertion of transforming DNA and generation of new deletions associated with transformation in Aspergillus nidulans. Mol Gen Genet 203:544-549
17. Fernández E, Moreno F, Rodicio R (1992) The ICL1 gene from Saccharomyces cerevisiae. Eur J Biochem 204:983-990
18. Fu YH, Paietta JV, Mannix DG, Marzluf GA (1989) cys-3, the positive-acting sulfur regulatory gene of Neurospora crassa, encodes a protein with a putative leucine zipper DNA binding element. Mol Cell Biol 9:1120-1127
19. Gainey LDS, Kolble K, Connerton IF (1991) Isolation and expression of the acetate-inducible isocitrate lyase gene (acu-3) from Neurospora crassa: evidence for a second constitutive isozyme. Mol Gen Genet 229:253-260
20. Giniger E, Ptashne M (1987) Transcription in yeast activated by a putative amphipathic α helix linked to a DNA binding unit. Nature 330:670-672
21. Harbury PB, Zhang T, Kim PS, Alber T (1993) A switch between two-, three-, and four-stranded coiled-coils in GCN4 leucine zipper mutants. Science 262:1401-1407
22. Hedges D, Proft M, Entian K-D (1995) CAT8. a new zinc cluster-encoding gene necessary for derepression of gluconeogenic enzymes in the yeast Saccharomyces cerevisiae. Mol Cell Biol 15:1915-1922
23. Higucli R (1990) Recombinant PCR. In: Innis MA, Gelfand DH, Sninsky JS, White TJ (eds) PCR protocols: a guide to methods and applications. Academic Press, San Diego, pp 177-183
24. Hope IA, Struhl K (1986) Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of yeast. Cell 46:885-894
25. Hynes MJ (1975) A cis-dominant regulatory mutation affecting enzyme induction in the eukaryote Aspergillus nidulans. Nature 253:210-212
26. Hynes MJ (1977) Induction of the acetamidase of Aspergillus nidulans by acetate metabolism. J Bacteriol 131:770-775
27. Hynes MJ, Corrick CM, Kelly JM, Littlejohn TG (1988) Identification of the sites of action for regulatory gene controlling the amdS gene of Aspergillus nidulans. Mol Cell Biol 8:2589-2596
28. Johnston M, Dover J (1987) Mutations that inactivate a yeast transcriptional regulatory protein cluster in an evolutionarily conserved DNA binding domain. Proc Natl Acad Sci USA 84:2401-2405
29. Kammerer B, Guyonvarch A, Hubert JC (1984) Yeast regulatory gene PPR1. I. Nucleotide sequence, restriction map and codon usage. J Mol Biol 180:239-250
30. Kanaan MN, Marzluf GA (1991) Mutational analysis of the DNA-binding domain of the Cys3 regulatory protein of Neurospora crassa. Mol Cell Biol 11:4356-4362
31. Kanaan MN, Fu Y-H, Marzluf GA (1992) The DNA binding domain of the Cys-3 regulatory protein of Neurospora crassa is bipartite. Biochemistry 31:3197-3203
32. Katz ME, Hynes MJ (1989) Isolation and analysis of the acetate regulatory gene, facB, from Aspergillus nidulans. Mol Cell Biol 9:5696-5701
33. Kelly JM (1980) Pleiotropic mutants of Aspergillus nidulans affected in carbon metabolism Ph. D. Thesis. La Trobe University, Bundoora, Victoria, Australia
34. Kelly JM, Hynes MJ (1982) The regulation of NADP-linked isocitrate dehydrogenase in Aspergillus nidulans. J Gen Microbiol 128:23-28
35. Kelly JM, Hynes MJ (1985) Transformation of the Aspergillus niger by the amdS gene of Aspergillus nidulans. EMBO J 4:475-479
36. Kelly JM, Hynes MJ (1987) Multiple copies of the amdS gene of Aspergillus nidulans cause titration of trans-acting regulatory proteins. Curr Genet 12:21-31
37. Kornberg HE (1966) The role and control of the glyoxylate cycle in Escherichia coli. Biochem J 99:1-11
38. Landschulz WH, Johnson PF, McKnight SL (1988) The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins. Science 240:1759-1764
39. Laughon A, Gesteland R (1984) Primary structure of the Saccharomyces cerevisiae GAL4 gene. Mol Cell Biol 4:260-267
40. Lesage P, Yang X, Carlson M (1996) Yeast SNFI protein kinase interacts with SIP4, a C6 zinc cluster transcriptional activator: a new role for SNF1 in the glucose response. Mol Cell Biol 16:1921-1928
41. Marczak JE, Brandriss MC (1991) Analysis of constitutive and non inducible mutations of the PUT3 transcriptional activator Mol Cell Biol 11:2609-2619
42. Mellon FM, Little PFR, Casselton LA (1987) Gene cloning and transformation in the basidiomycete fungus Coprinus cinereus: isolation and expression of the isocitrate lyase gene (acu-7). Mol Gen Genet 210:352-357
43. Morelle G (1989) A plasmid extraction procedure on a miniprep scale. Focus 11:7-8
44. Oakley CE, Weil CF, Kretz PL, Oakley BR (1987) Cloning of the riboB locus of Aspergillus nidulans. Gene 53:293-298
45. Paietta JV (1995) Analysis of Cys3 regulator function in Neurospora crassa by modification of leucine zipper dimerization specificty. Nucleic Acids Res 23:1044-1049
46. Parsons LM, Davis MA, Hynes MJ (1992) Identification of functional regions of the positively acting regulatory gene amdR from Aspergillus nidulans. Mol Microbiol 6:2999-3007
47. Pfeifer K, Prezant T, Guarente L (1987) Yeast HAP1 activator hinds to two upstream activation sites of different sequence. Cell 49:19-27
48. Robbins J, Dilworth SM, Laskey RA, Dingwall C (1991) Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: identification of a class of bipartite targeting sequence. Cell 64:615-623
49. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
50. Sandeman RA, Hynes MJ (1989) Isolation of the facA (acetyl-Coenzyme A synthetase) and acuE (malate synthase) genes of Aspergillus nidulans. Mol Gen Genet 218:87-92
51. Sanger F, Nicklen S, Coulson AR (1977) DNA sequencing with chain termination inhibitors. Proc Natl Acad Sci USA 74:5463-5467
52. Schöler A, Schüller H-J (1993) Structure and regulation of the isocitrate lyase gene ICL1 from the yeast Saccharomyces cerevisiae. Curr Genet 23:375-381
53. Sealy-Lewis HM (1994) A new selection method for isolating mutants defective in acetate utilisation in Aspergillus nidulans. Curr Genet 25:47-48
54. Thomas GH, Connerton IF, Fincham JRS (1988) Molecular cloning, identification and transcriptional analysis of genes involved in acetate utilization in Neurospora crassa. Mol Microbiol 2:599-606
55. Thompson JD, Higgins DG, Gibson TJ (1994) CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position specific gap penalties and weight matrix choice. Nucleic Acids Res 22:4673-4680
56. Triezenberg SJ, Kingsbury RC, McKnight SL (1988) Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression. Genes Dev 2:718-729
57. Turcotte B, Guarente L (1992) HAP1 positive control mutants specific for one of two binding sites. Genes Dev 6:2001-2009
58. Yang Z, Hubbard EJA, Carlson M (1992) A protein kinase substrate identified by the two-hybrid system. Science 257:680-682
59. Zhou K, Brisco PR, Hinkkanen AE, Kohlhaw GB (1987) Structure of the yeast regulatory gene LEU3 and evidence that LEU3 itself is under general amino acid control. Nucleic Acids Res 15:5261-5273