The alternate iron transport pathway: Mobilferrin and integrin in reticulocytes

British Journal of Haematology

Volumn 96, Issue 3, 1997, Pages 521-529

  Umbreit, Jay N ^a   Conrad, Marcel E ^a   Berry, Michael A ^a   Moore, Elizabeth G ^a   Latour, Lydia F ^a   Tolliver, Beth A ^a   Elkhalifa, Mohamed Y ^a  

^a UNIVERSITY OF SOUTH ALABAMA   (United States)

Author keywords

Calreticulin; Erythroid; Haemochromatosis; Metals; Transferrin

Indexed keywords

CALRETICULIN; INTEGRIN; MOBILFERRIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HEMOCHROMATOSIS; IRON TRANSPORT; MALE; NONHUMAN; PRIORITY JOURNAL; RETICULOCYTE;

ANIMALS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; FERRIC COMPOUNDS; HEMOGLOBINS; INTEGRINS; IRON; IRON-BINDING PROTEINS; RATS; RATS, WISTAR; RETICULOCYTES; TRANSFERRIN;

EID: 0031025255     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1997.d01-2069.x     Document Type: Article

References (30)

1. Bakoy, O.E. & Thorstensen, R. (1994) The process of cellular uptake of iron from transferrin. European Journal of Biochemistry. 222. 105-112.
2. Brissot, P., Wright, T.L., Ma, W.L. & Weisinger, R.A. (1985) Characterization of non-transferrin bound iron clearance by rat liver. Journal of Clinical Investigation, 76, 1463-1470.
3. Conrad, M.E. & Umbreit, J.N. (1994) An integrin-mobilferrin iron transport pathway in intestine and hematopoietic cells. American Journal of Hematology, 42, 67-75.
4. Conrad, M.E., Umbreit, J.N. & Moore, E.G. (1991) A role for mucin in the absorption of iron and other metal cations. Gastroenterology. 100, 129-136.
5. Conrad, M.E., Umbreit, J.N., Moore, E.G., Peterson, R.D.A. & Jones, M.B. (1990) A newly identified iron binding protein in duodenal mucosa of rats: purification and characterization of mobilferrin. Journal of Biological Chemistry. 265, 5273-5279.
6. Conrad, M.E., Umbreit, J.N., Moore, E.G., Uzel, C. & Berry, M.R. (1994) Alternate iron transport pathway, mobilferrin and integrin in K562 cells, Journal of Biological Chemistry. 269, 7169-7173
7. Conrad, M.E., Umbreit, J.N., Peterson, R.D.A., Moore, E.G. & Harper, K.P. (1993) Function of integrin in duodenal mucosal uptake of iron. Blood. 81. 517-521.
8. Craven, E.M., Alexander, J., Eldridge, M., Kusher, J.P., Bernstein. D. & Kaplan, J. (1987) Tissue distribution and clearance kinetics of non-transferrin-bound iron in the hypotransferrinemic mouse: a rodent model for hemochromatosis. Proceedings of the National Academy of Sciences of the United States of America, 84, 3457-3462.
9. Egyed, A. (1988) Carrier mediated iron transport through erythroid cell membrane. British Journal of Haematology. 68.483-486.
10. Fairbanks, V.F. & Beutler, E. (1983) Hematology. p. 474. McGraw-Hill, New York.
11. Fuchs. O., Borová, J., Hradilek, A. & Neuwirt, J. (1988) Nontransferrin donors of iron for heme synthesis in immature erythroid cells. Biochimica et Biophysica Acta, 969, 158-165.
12. Hemmaplardh, D. & Morgan, E.H. (1974) The role of endocytosis in iron transferrin uptake by reticulocytes and bone marrow cells. Biochimica et Biophysica Acta, 373, 84-99.
13. Hodgson, L.L., Quail, E.A. & Morgan, E.H. (1994) Receptor independent uptake of transferrin bound iron in reticulocytes. Archives of Biochemistry and Biophysics. 308, 318-326.
14. Inman, R.S. & Wessling-Resnick, M. (1993) Characterization of transferrin-independent iron transport in K562 cells. Journal of Biological Chemistry. 268, 8521-8528.
15. Kaplan, J., Jordan, I. & Sturrick, A. (1991) Regulation of the transferrin-independent iron transport system in cultured cells. Journal of Biological Chemistry, 266, 2997-3004.
16. Klausner, R.O., Renswoude, J.V., Ashwell, G., Kempt, C., Schechter, A.N., Dean, A. & Bridges, K.R. (1983) Receptor mediated endocytosis of transferrin in K562 cells. Journal of Biological Chemistry, 258, 4715-4724.
17. Morgan, E.H. (1988) Membrane transport of non-transferrin-bound iron by reticulocytes. Biochimica et Biophysica Acta, 943, 428-439.
18. Muir, W.A., Hopfer, U. & King, M. (1984) Iron transport across brush-border membranes from normal and iron-deficient mouse upper small intestine. Journal of Biological Chemistry, 259, 4846-4903.
19. +2 transport. Journal of Biological Chemistry. 267, 11490-11494.
20. Papayannopoulou, T. & Brice, M. (1992) Intergrin expression profiles during erythroid maturation. Blood, 79, 1686-1694.
21. Parmley, R.T., Barton, J.C. & Conrad, M.E. (1985) Ultrastructural localization of transferrin, transferrin receptor and iron binding sites on human placental and duodenal microvilli. British Journal of Haematology, 60, 81-89.
22. Pollack, S., Compana, T. & Weaver, J. (1985) Low molecular weight iron in guinea pig reticulocytes. American Journal of Hematology, 19, 75-84.
23. Richardson, D.R., Ponka, P. & Vyoral, D. (1996) Distribution of iron in reticulocytes after inhibition of heme synthesis with succinyl acetone: examination of the intermediates involved in iron metabolism. Blood, 87, 3477-3488.
24. Seligman, P.A., Kovar, J., Schleicher, R.B. & Gelfand, E.W. (1991) Transferrin-independent iron uptake supports B lymphocyte growth. Blood, 78, 1526-1531.
25. Spiro, T.G., Bates, G. & Saltman, P. (1967) The hydrolytic polymerization of ferric citrate. II. The influence of excess citrate. Journal of the American Chemical Society. 89, 5559-5562.
26. Sturrock, A., Alexander, J., Lamb, J., Graven, C.M. & Kaplan, J. (1990) Characterization of a transferrin-independent uptake system for iron in HeLa cells. Journal of Biological Chemistry, 265, 3139-3145.
27. Umbreit, J.N., Conrad, M.E., Moore, E.G., Desai, M.P. & Turrens, J. (1996) Paraferritin: a protein complex with ferireductase activity is associated with iron absorption in rats. Biochemistry, 35, 6460-6469.
28. Wolf, G. & Wessling-Resnick, M. (1994) An integrin-mobilferrin iron transport pathway in intestine and hematopoietic cells. Nutritional Review, 52, 287-289.
29. Wright, T.L., Brissot, P., Ma, W.L. & Weisinger, R.A. (1986) Characterization of non transferrin-bound iron clearance by rat liver. Journal of Biological Chemistry, 261, 10909-10914.
30. Wright, T.L., Fitz, J.G., Weisinger, R.A. & Jun, P. (1988) Non-transferrin-bound iron uptake by rat liver: role of membrane potential difference. Journal of Biological Chemistry, 263, 1842-1847.