Trefoil peptides in the defense of the gastrointestinal tract

New England Journal of Medicine

Volumn 336, Issue 7, 1997, Pages 506-507

  Plaut, Andrew G ^a  

^a TUFTS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDE;

AMINO ACID SEQUENCE; ARTICLE; GASTROINTESTINAL TRACT; HOST RESISTANCE; HUMAN; IMMUNOREACTIVITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; GENE DELETION; GROWTH SUBSTANCES; HUMANS; INTESTINAL MUCOSA; MICE; MOLECULAR SEQUENCE DATA; MUCINS; MUSCLE PROTEINS; NEOPLASM PROTEINS; NEUROPEPTIDES; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; PROTEINS; TUMOR SUPPRESSOR PROTEINS;

EID: 0031024528     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199702133360712     Document Type: Article

References (4)

1. Mashimo H, Wu D-C, Podolsky DK, Fishman MC. Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor. Science 1996; 274:262-5.
2. Lefebvre O, Chenard M-P, Masson R, et al. Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein. Science 1996;274:259-62.
3. Thim L. A new family of growth factor-like peptides: "trefoil" disulphide loop structures as a common feature in breast cancer associated peptide (pS2), pancreatic spasmolytic polypeptide (PSP), and frog skin peptides (spasmolysins). FEBS Lett 1989:250:85-90.
4. Wright NA, Poulsom R, Stamp G, et al. Trefoil peptide gene expression in gastrointestinal epithelial cells in inflammatory bowel disease. Gastroenterology 1993;104:12-20.