8-(N,N-diethylamino)-n-octyl-3,4,5-trimethoxybenzoate actions on calcium dynamics in cultured vascular smooth muscle cells

Acta Pharmacologica Sinica

Volumn 18, Issue 1, 1997, Pages 21-24

  Liu, Shirley X L ^a   Chiou, George C Y ^a   Chen, Zhou ^a  

^a TEXAS A M COLLEGE OF MEDICINE   (United States)

Author keywords

calcium; hydroquinones; nifedipine; norepinephrine; ryanodine; TMB; vascular smooth muscle

Indexed keywords

2,5 DI TERT BUTYLHYDROQUINONE; 3,4,5 TRIMETHOXYBENZOIC ACID 8 (DIETHYLAMINO)OCTYL ESTER; CALCIUM; CALCIUM ANTAGONIST; FURA 2; NIFEDIPINE; NORADRENALIN; RYANODINE;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL CULTURE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG MECHANISM; DRUG POTENTIATION; EMBRYO; NONHUMAN; RAT; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

EID: 0031017898     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Chiou GCY, Hong SJ. Prevention and reduction of neural damage in ischemic strokes by ω-( N, N′-diethylamino)-n-alkyl-3,4,5-trimethoxybenzoate compounds. J Pharmacol Exp Ther 1995; 275: 474-8.
2. 2+ antagonist, 8-(N, N-diethylamino)-octyl-3, 4, 5-trimethoxybenzoate hydrochloride (TMB-8): studies in smooth muscles. Eur J Pharmacol 1974; 27: 25-33.
3. 2+ antagonist, 8-( N, N-diethylamino)-octyl-3, 4, 5-trimethoxybenzoate hydrochloride (TMB-8): studies in skeletal muscles. Pharmacology 1974; 12: 20-31.
4. 2+ antagonist, 8-(N, N-diethylamino)-octyl-3, 4, 5-trimethoxybenzoate hydrochloride in smooth and skeletal muscles. Br J Pharmacol 1975; 53; 279-85.
5. Posner P, Chiou CY. Electrophysiological studies of 6-(N, N-diethylamino)-hexyl-3, 4, 5-trimethoxybenzoate on ventricular muscle and conduction system. Pharmacology 1976; 14: 97-103.
6. Chiou CY, Malagodi MH, Sastry BVR, Posner P. Effects of calcium antagonist, 6-(N, N-diethylamino)-hexyl-3, 4, 5-trimethoxybenzoate, on digitalis-induced arrhythmias and cardiac contractions. J Pharmacol Exp Ther 1976; 198: 444-9.
7. Chiou GCY, McLaughlin MA. Effects of 5-(N, N-diethylamino)-n-pentyl-3, 4, 5-trimethoxybenzoate hydrochloride (TMB-5) on cardiovascular systems. Eur J Pharmacol 1982; 81: 587-94.
8. Vassalle M, Barnabei O. Norepinephrine and potassium fluxes in cardiac Purkinje fibers. Pflügcrs Arch 1971; 322: 287-303.
9. Putney JW. A model for receptor-regulated calcium entry. Cell Calcium 1986; 7: 1-12.
10. Putney JW. Capacitative calcium entry revisited. Cell Calcium 1990; 11: 611-24.
11. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 1985; 260: 3440-50.
12. Xiao J, Liu XL, Chen Z, Chiou GCY. Vasodilation effects and action mechanisms of TMB-8 on basal artery in rabbits. J Cardiovasc Pharmacol Ther 1996: in press.
13. Chen Z, Liu XL, Chiou GCY. Studies on action mechanisms of 8-(N, N-diethylamino)-n-octyl-3,4,5-trimethoxybenzoate (TMB-8) in vascular smooth muscle cell cultures. J Cardiovasc Pharmacol Ther 1996: in press.
14. 2+ sequestration. FEBS Lett 1987; 224: 331-6.
15. 2+ -influx pathway. Biochem J 1992; 284: 521-30.