Vasodilation effects and action mechanisms of TMB-8 on basilar artery in rabbits

Journal of Cardiovascular Pharmacology and Therapeutics

Volumn 1, Issue 4, 1996, Pages 325-332

  Xiao, Jigao ^a   Liu, Shirley X L ^a   Chen, Zhou ^a   Chiou, George C Y ^a  

^a TEXAS A M COLLEGE OF MEDICINE   (United States)

Author keywords

Ca2+ antagonist; cAMP; Intracellular Ca2+ store; Ischemic stroke; TMB 8

Indexed keywords

EID: 0008917413     PISSN: 10742484     EISSN: 19404034     Source Type: Journal    
DOI: 10.1177/107424849600100408     Document Type: Article

References (16)

1. 2+ antagonist, 8-(N,N'-diethylamino)-n-octyl3,4.5-trimethoxybenzoate hydrochloride (TMB-8) in smooth and skeletal muscle. Br J Pharmacol 53:279, 1975.
2. Chiou GCY, Hong SY. Prevention and reduction of neural damage in ischemic strokes by w-(N,N'diethylamino)-n-alkyl-3,4,5-trimethoxybenzoate compounds. J Pharmacol Exp Ther 275:474, 1995.
3. 2+ antagonist. 8-(N,N'-diethylamino)-n-octyl 3,4,5-trimethoxybenzoate hydrochloride (TMB-8): studies in smooth muscles. Eur J Pharmacol 27:25, 1974.
4. 2+ antagonist, 8-(N,N'-diethylamino)-n-octyl 3,4,5-trimethoxybenzoate hydrochloride (TMB-8): studies in skeletal muscles. Pharmacology 12:20, 1974.
5. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260:3440, 1985.
6. Moore GA, McConkey DJ, Kass GEN, O'Bries PJ, Orrenius S. 2,5-di(tertbutyl)-1.4-benzohydroquinone: a novel inhibitor of liver microsomal calcium sequestration. FEBS Lett 224:331, 1987.
7. Kanmura Y, Missiaen L, Raeymaeker SL, Casteels R. Ryanodine reduces the amount of calcium in intracellular stores of smooth muscle cells of the rabbit ear artery. Pflügers Arch Europ J Physiol 413:153, 1988.
8. Singh YN, Lamberty MA, Johnson A, Adam TJ. Effects of TMB-8, a putative calcium antagonist, on neuromuscular transmission and muscle contractility in the mouse phrenic nerve-hemidiaphragm preparation. Arch Int Pharmacodyn Ther 327:363, 1991.
9. Voldby B, Petersen OF, Buhl M, Jakobsen P, Ostergaard R. Reversal of cerebral artery spasm of a calcium antagonist. Acta Neurochir 70:243, 1984.
10. 2+ antagonists. 6-(N,N'diethylamino)hexy3,4,5-trimeth-oxybenzoate, on digitalis-induced arrhythmias and cardiac contraction. J Pharmacol Exp Ther 198:444, 1976.
11. Chiou GCY, McLaughlin MS. Effects of 5-(N,N'-diethyl-amino)-n-pentyl-3,4,5-trimethoxybenzoate hydrochloride (TMB-5) on cardiovascular system. Eur J Pharmacol 81:587, 1982.
12. Posner P, Chiou GCY. Electrophysiological studies of 6-(N,N'-diethylamino) hexyl 3,4,5-trimethoxybenzoate on ventricular muscle and conduction system. Pharmacology 14:97, 1976.
13. Nishikibe M, Nakajima A. Effects of the calcium antagonist NB-818 on cerebral blood flow. Life Sci 43:1715, 1988.
14. Siesjo BK. Mechanisms of ischemic brain damage. Crit Care Med 16:954, 1988.
15. Parks TN, Artman LD, Alasti N, Nemeth EF. Modulation of N-methyl-D-aspatate receptor-mediated increase in cytosolic calcium in cultured rat cerebellar granule cells. Brain Res 555:13, 1991.
16. 2+ antagonist in cultured mouse cortical neurons. Neuroreport 5:605, 1994.