New species of human tyrosine hydroxylase mRNA are produced in variable amounts in adrenal medulla and are overexpressed in progressive supranuclear palsy

Journal of Neurochemistry

Volumn 67, Issue 1, 1996, Pages 19-25

  Dumas, Sylvie ^a   Le Hir, Hervé ^b   Bodeau Péan, Sylvie ^a   Hirsch, Etienne ^a   Thermes, Claude ^b   Mallet, Jacques ^a  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b CNRS   (France)

Author keywords

Adrenal medulla; Alternative splicing; Progressive supranuclear palsy; Tyrosine hydroxylase isoforms

Indexed keywords

MESSENGER RNA; TYROSINE 3 MONOOXYGENASE;

ADRENAL MEDULLA; ARTICLE; ENZYME ASSAY; ENZYME LOCALIZATION; GENE EXPRESSION; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; PROGRESSIVE SUPRANUCLEAR PALSY; PROTEIN EXPRESSION; RNA ANALYSIS; TISSUE SPECIFICITY;

EID: 0029889629     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1996.67010019.x     Document Type: Article

References (46)

1. Almas B., Le Bourdellès B., Flatmark T., Mallet J., and Haavik J. (1992) Regulation of recombinant human tyrosine hydroxylase isoenzymes by catecholamine binding and phosphorylation. Structure-activity studies and mechanistic implications. Eur. J. Biochem. 209, 249-255.
2. Baruchin A., Weisberg E. P., Miner L. L., Ennis D., Nisenbaum L., Naylor E., Stricker E. M., Zigmond M. J., and Kaplan B. B. (1990) Effects of cold exposure on rat adrenal tyrosine hydroxylase: an analysis of RNA, protein, enzyme activity, and cofactor levels. J. Neurochem. 54, 1769-1775.
3. Birman S., Morgan B., Anzivino M., and Hirsh J. (1994) A novel and major isoform of tyrosine hydroxylase in Drosophila is generated by alternative RNA processing. J. Biol. Chem. 269, 26559-26567.
4. Campbell D. G., Hardie D. G., and Vulliet P. R. (1986) Identification of four phosphorylation sites in the N-terminal region of tyrosine hydroxylase. J. Biol. Chem. 261, 10489-10492.
5. Cervini R., Berrard S., Béjanin S., and Mallet J. (1994) Regulation by CDF/LlF and retinoic acid of multiple ChAT mRNAs produced from distinct promoters. Neuroreport 5, 1346-1348.
6. Coker G. T. III, Studelska D., Harmon S., Burke W., and O'Malley K. L. (1990) Analysis of tyrosine hydroxylase and insulin transcripts in human neuroendocrine tissues. Mol. Brain Res. 8, 93-98.
7. Daubner S. C., Lohse D. L., and Fitzpatrick P. F. (1993) Expression and characterization of catalytic and regulatory domains of rat tyrosine hydroxylase. Protein Sci. 2, 1452-1460.
8. D'Mello S. R., Weisberg E. P., Stachowiak M. D., Turzai L. M., Gioio A. E., and Kaplan B. B. (1988) Isolation and nucleotide sequence of a cDNA clone encoding bovine adrenal tyrosine hydroxylase: comparative analysis of tyrosine hydroxylase gene products. J. Neurosci. Res. 19, 440-449.
9. Dumas S., Horellou P., Helin C., and Mallet J. (1992) Co-expression of tyrosine hydroxylase messenger RNA 1 and 2 in human ventral mesencephalon revealed by digoxigenin- and biotin-labelled oligodeoxyribonucleotides. J. Chem. Neuroanat. 5, 11-18.
10. Fauquet M., Grima B., Lamouroux A., and Mallet J. (1988) Cloning of quail tyrosine hydroxylase: amino acid homology with other hydroxylases discloses functional domains. J. Neurochem. 50, 142-148.
11. Funakoshi H., Okuno S., and Fujisawa H. (1991) Different effects on activity caused by phosphorylation of tyrosine hydroxylase at serine 40 by three multifunctional protein kinases. J. Biol. Chem. 266, 15614-15620.
12. Ginns E. I., Rehavi M., Martin B. M., Weller M., O'Malley K. L., Lamarca M. E., McAllister C. G., and Paul S. M. (1988) Expression of human tyrosine hydroxylase cDNA in invertebrate cells using a baculovirus vector. J. Biol. Chem. 263, 7406-7410.
13. Goldstein M. (1995) Long- and short-term regulation of tyrosine hydroxylase, in Psychopharmacology: The Fourth Generation of Progress (Bloom F. E. and Kupfer D. J., eds), pp. 189-195. Raven Press, New York.
14. Grima B., Lamouroux A., Blanot F., Faucon Biguet N., and Mallet J. (1985) Complete coding sequence of rat tyrosine hydroxylase mRNA. Proc. Natl. Acad. Sci. USA 82, 617-621.
15. Grima B., Lamouroux A., Boni C., Julien J.-F., Javoy-Agid F., and Mallet J. (1987) A single human gene encoding multiple tyrosine hydroxylase with different predicted functional characteristics. Nature 326, 707-711.
16. Haavik J., Martinez A., and Flatmark T. (1990) pH-dependent release of catecholamines from tyrosine hydroxylase and the effect of phosphorylation of Ser-40. FEBS Lett. 262, 363-365.
17. Haavik J., Le Bourdellès B., Martinez A., Flatmark T., and Mallet J. (1991) Recombinant human tyrosine hydroxylase isoenzymes. Reconstitution with iron and inhibitory effect of other metal ions. Eur. J. Biochem. 199, 371-378.
18. Harrison P. J., Procter A. W., Barton A. J. L., Lowe S. L., Najlerahim A., Bertolucci P. H. F., Bowen D. M., and Pearson R. C. A. (1991) Terminal coma affects messenger RNA detection in post mortem human temporal cortex. Mol. Brain Res. 9, 161-164.
19. Hauw J. J., Daniel S. E., Dickson D., Horoupian D. S., Jellinger K., Lantos P. L., McKee A., Tabaton M., and Litvan I. (1994) Preliminary NINDS neuropathologic criteria for Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy). Neurology 44, 2015-2019.
20. 40. Neurochem. Res. 18, 15-26.
21. Haycock J. W. and Wakade A. R. (1992) Activation and multiple-site phosphorylation of tyrosine hydroxylase in perfused rat adrenal glands. J. Neurochem. 58, 57-64.
22. Higushi R. (1989) PCR Technology, Principles and Applications for DNA Amplification (Erlich H. A., ed), pp. 61-70. Stockton Press, New York.
23. Horellou P., Le Bourdellès B., Clot-Humbert J., Guibert B., Leviel V., and Mallet J. (1988) Multiple human tyrosine hydroxylase enzymes, generated through alternative splicing, have different specific activities in Xenopus oocytes. J. Neurochem. 51, 652-655.
24. Icard-Liepkalns C., Berrard S., Faucon Biguet N., Lebourdellès B., Ravassard P., Robert J. J., and Mallet J. (1993) Tyrosine hydroxylase regulation in neurotransmission and neuroplasticity. J. Physiol. (Lond.) 87, 153-157.
25. Ichikawa S., Ichinose H., and Nagatsu T. (1990) Multiple mRNAs of monkey tyrosine hydroxylase. Biochem. Biophys. Res. Commun. 173, 1331-1336.
26. Ichikawa S., Sasaoka T., and Nagatsu T. (1991) Primary structure of mouse tyrosine hydroxylase deduced from its cDNA. Biochem. Biophys. Res. Commun. 176, 1610-1616.
27. Kobayashi K., Kaneda N., Ichinose H., Kishi F., Nakazawa A., Kurosawa Y., Fujita K., and Nagatsu T. (1988a) Structure of the human tyrosine hydroxylase gene: alternative splicing from a single gene accounts for generation of four mRNA types. J. Biochem. (Tokyo) 103, 907-912.
28. Kobayashi K., Kiuchi K., Ishii A., Kaneda N., Kurosawa Y., Fujita K., and Nagatsu T. (1988b) Expression of four types of human tyrosine hydroxylase in COS cells. FEBS Lett. 238, 431-434.
29. Lanièce P., Le Hir H., Bodeau-Péan S., Charon Y., Valentin L., Thermes C., Mallet J., and Dumas S. (1996) A novel rat tyrosine hydroxylase mRNA species generated by alternative splicing. J. Neurochem. 66, 1819-1825.
30. Le Bourdellès B., Boularand S., Boni C., Horellou P., Dumas S., Grima B., and Mallet J. (1988) Analysis of the 5′ region of human tyrosine hydroxylase gene: combinatorial patterns of exon splicing generate multiple regulated tyrosine hydroxylase isoforms. J. Neurochem. 50, 988-991.
31. Le Bourdellès B., Horellou P., Le Caer J. P., Denefle P., Latta M., Haavik J., Guibert B., Mayaux J. F., and Mallet J. (1991) Phosphorylation of human recombinant tyrosine hydroxylase isoforms 1 and 2: an additional phosphorylated residue in isoform 2, generated through alternative splicing. J. Biol. Chem. 266, 17124-17130.
32. Leviel V., Guibert B., Mallet J., and Faucon-Biguet N. (1991) Induction of tyrosine hydroxylase in the rat substantia nigra by local injection of forskolin. J. Neurosci. Res. 30, 427-432.
33. Lewis D. A., Melchitzky D. S., and Haycock J. W. (1993) Four isoforms of tyrosine hydroxylase are expressed in human brain. Neuroscience 54, 477-492.
34. Lewis D. A., Melchitzky D. S., and Haycock J. W. (1994) Expression and distribution of two isoforms of tyrosine hydroxylase in macaque monkey brain. Brain Res. 656, 1-13.
35. Malessa S., Hirsch E. C., Cervera P., Duyckaerts C., and Agid Y. (1990) Catecholaminergic systems in the medulla oblongata in parkinsonian syndrome: a quantitative immunohistochemical study in Parkinson's disease, progressive supranuclear palsy and striatonigral degeneration. Neurology 40, 1739-1743.
36. Mallet J., Faucon Biguet N., Horellou P., Icard-Liepkalns C., Lundberg C., Robert J. J., Vyas S., and Björlund A. (1992) Neurotransmitter expression: from regulation to neuropsychiatric disorders. Miti's Booklet. Tokyo 33, 42-47.
37. Nagatsu T. (1991) Genes for human catecholamine-synthesizing enzymes. Neurosci. Res. 12, 315-345.
38. Nasrin S., Ichinose H., Hidaka H., and Nagatsu T. (1994) Recombinant human tyrosine hydroxylase types 1-4 show regulatory kinetic properties for the natural (6R)-tetrahydrobiopterin co-factor. J. Biochem. (Tokyo) 116, 393-398.
39. Neckaemeyer W. S. and Quinn W. G. (1989) Isolation and characterization of the gene for Drosophila tyrosine hydroxylase. Neuron 2, 1167-1175.
40. O'Malley K. L., Anhalt M. J., Martin B. M., Kelsoe J. R., Winfield S. L., and Ginns E. I. (1987) Isolation and characterization of the human tyrosine hydroxylase gene: identification of 5′ alternative splice sites responsible for multiple mRNAs. Biochem. J. 26, 6910-6914.
41. Pearson R. B., Woodgett J. R., Cohen P., and Kempf B. E. (1985) Substrate specificity of multifunctional protein kinase. J. Biol. Chem. 260, 471-476.
42. Schussler N., Boularand S., Li J. Y., Peillon F., Mallet J., and Faucon Biguet N. (1995) Multiple tyrosine hydroxylase transcripts and immunoreactive forms in the rat: differential expression in the anterior pituitary and adrenal gland. J. Neurosci. Res. 42, 846-854.
43. Sutherland C., Alterio J., Campbell D. G., Le Bourdellès B., Mallet J., Haavik J. and Cohen P. (1993) Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen-activated protein (MAP) kinase and MAP-kinase-activated kinases 1 and 2. FEBS Lett. 217, 715-722.
44. Vrana K. E., Walker S. J., Rucker P., and Liu X. (1994) A carboxyl terminal leucine zipper is required for tyrosine hydroxylase tetramer formation. J. Neurochem. 63, 2014-2020.
45. Zigmond R. E. (1985) Biochemical consequences of synaptic stimulation. The regulation of tyrosine hydroxylase activity by multiple transmitters. Trends Neurosci. 8, 63-69.
46. Zigmond R. E., Schwarzschild M. A., and Rittenhouse A. R. (1989) Acute regulation of tyrosine hydroxylase by nerve activity and by neurotransmitters via phosphorylation. Annu. Rev. Neurosci. 12, 415-461.