Nasal vasoconstriction and decongestant effects of nitric oxide synthase inhibition in the pig

Acta Physiologica Scandinavica

Volumn 157, Issue 2, 1996, Pages 233-244

  Rinder, J ^a,b   Lundberg, J M ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Adrenoceptor agonists; Capsaicin; N(w) nitro L arginine; Nasal mucosa; Nitric oxide; Vascular regulation

Indexed keywords

ACETYLCHOLINE; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; ARGININE; BRIMONIDINE; CAPSAICIN; DECONGESTIVE AGENT; N(G) NITROARGININE; NITRIC OXIDE SYNTHASE; NITROPRUSSIDE SODIUM; PHENYLEPHRINE; SUBSTANCE P; VASOACTIVE INTESTINAL POLYPEPTIDE;

ADRENERGIC ACTIVITY; ANIMAL EXPERIMENT; ARTICLE; BLOOD FLOW; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; FEMALE; INTRAARTERIAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; NOSE CAVITY; NOSE CONGESTION; NOSE MUCOSA; PRIORITY JOURNAL; RHINOMANOMETRY; SWINE; SYMPATHETIC NERVE; VASCULARIZATION; VASOCONSTRICTION;

EID: 0029938607     PISSN: 00016772     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-201X.1996.509246000.x     Document Type: Article

References (48)

1. Alving, K., Fornhem, C. & Lundberg, J.M. 1993. Pulmonary effects of endogenous and exogenous nitric oxide in the pig: relation to cigarette smoke inhalation. Br J Pharmacol 110, 739-746.
2. Amezcua, J.L., Palmer, R.M.J., de Souza, B.M. & Moncada, S. 1989. Nitric oxide synthesized from L-arginine regulates vascular tone in the coronary circulation of the rabbit. Br J Pharmacol 97, 1119-1124.
3. Austin, C.E. & Foreman, J.C. 1994. Acoustic rhinometry compared with posterior rhinomanometry in the measurement of histamine- and bradykinin-induced changes in nasal airway patency. Br J Clin Pharmacol 37, 33-37.
4. Bende, M. 1983. Blood flow in human nasal mucosa. Thesis, University of Lund, Sweden.
5. Bredt, D.S., Glatt, C.E., Hwang, P.M., Fotuhi, M., Dawson, T.M. & Snyder, S.H. 1991. Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase. Neuron 7, 615-624.
6. Ceccatelli, S., Lundberg, J.M., Fahrenkrug, J., Bredt, D.S., Snyders, S. & Hökfelt, T. 1992. Evidence for involvement of nitric oxide in the regulation of hypothalamic blood flow. Neuroscience 51, 769-772.
7. Feletou, M. & Vanhoutte, P.M. 1988. Endothelium-dependent hyperpolarization of canine coronary smooth muscle. Br J Pharmacol 93, 515-524.
8. Furchgott, R.F. & Zawadzki, J.V. 1980. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288, 373-376.
9. Ganz, P., Sandrock, A.W., Landis, S.C., Leopold, J., Gimbrone, M.A. & Alexander, R.W. 1986. Vasoactive intestinal polypeptide: vasodilatation and cyclic AMP generation. Am J Physiol 250, H755-H760.
10. G-nitro-L-arginine methyl ester. Br J Pharmacol 101, 632-639.
11. Garland, C.J. & McPherson, G.A. 1992. Evidence that nitric oxide does not mediate the hyperpolarization and relaxation to acetylcholine in the rat small mesenteric artery. Br J Pharmacol 105, 429-435.
12. Gustafsson, L.E., Wiklund, C.U., Wiklund, N.P., Persson, M.G. & Moncada, S. 1990. Modulation of autonomic neuroeffector transmission by nitric oxide in guinea pig ileum. Biochem Biophys Res Commun 173(1), 106-110.
13. Hanazawa, T., Motosugi, H., Konno, A., Kaneko, T., Tanaka, K. & Chiba, T. 1993. Distribution of NADPH-diaphorase positive nerve fibers in the rat nasal mucosa. Neurosci Lett 159, 71-74.
14. Hilberg, O., Jackson, A.C., Swift, D.L. & Pedersen, O.F. 1989. Acoustic rhinometry: evaluation of nasal geometry by acoustic reflection. J Appl Physiol 66(1), 295-303.
15. Holzer, P. & Jocic, M. 1994. Cutaneous vasodilatation induced by nitric oxide-evoked stimulation of afferent nerves in the rat. Br J Pharmacol 112, 1181-1187.
16. Ignarro, L.J., Buga, G.M., Wood, K.S., Byrns, R.E. & Chaudhuri, G. 1987. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA 84, 9265-9269.
17. Iyengar, R., Stuehr, D.J. & Marletta, M.A. 1987. Macrophage synthesis of nitrite, nitrate and n-nitrosamines: precursors and role of the respiratory burst. Proc Natl Acad Sci USA 84, 6369-6373.
18. Jackson, A.C., Butler, J.P., Millet, E.J., Hoppin, Jr, F.G. & Dawson, S.V. 1977. Airway geometry by analysis of acoustic pulse response measurements. J Appl Physiol 43, 523-536.
19. Kaley, G., Rodenburg, M., Messina, E.J. & Wolin, M.S. 1989. Endothelium-associated vasodilators in rat skeletal muscle microcirculation. Am J Physiol 256 (Heart Circ Physiol 25), H720-H725.
20. Kerezoudis, N.P., Olgart, L. & Edwall, L. 1993. Differential effects of nitric oxide synthesis inhibition on basal blood flow and antidromic vasodilation in rat oral tissues. Eur J Pharmacol 241, 209-219.
21. Kowaluk, E.A., Seth, P. & Fung, H.-L. 1992. Metabolic activation of sodium nitroprusside to nitric oxide in vascular smooth muscle. J Pharmacol Exp Ther 262, 916-922.
22. Kummer, W., Fischer, A., Mundel, P., Mayer, B., Hoba, B., Philippin, B. & Preissler, U. 1992. Nitric oxide synthase in VIP-containing vasodilator nerve fibres in the guinea-pig. NeuroReport 3, 653-655.
23. Lacroix, J.S., Stjärne, P., Änggård, A. & Lundberg, J.M. 1988. Sympathetic vascular control of the pig nasal mucosa. (2). Reserpine-resistant, non-adrenergic nervous responses in relation to neuropeptide Y and ATP. Acta Physiol Scand 133, 183-197.
24. Lundberg, J.M. 1981. Evidence for coexistence of vasoactive intestinal polypeptide (VIP) and acetylcholine in neurons of cat exocrine glands. Morphological, biochemical and functional studies. Acta Physiol Scand Suppl. 496.
25. Lundberg, J.M., Hökfelt, T., Änggård, A., Terenius, L., Elde, R., Markey, K. & Goldstein, M. 1982. Organization principles in the peripheral sympathetic nervous system: subdivision by co-existing peptides (somatostatin-, avian pancreatic polypeptide- and vasoactive intestinal polypeptide-like immunoreactive materials). Proc Natl Acad Sci USA 79, 1303-1307.
26. Lundberg, J.O.N., Farkas-Szallasi, T., Weitzberg, E., Rinder, J., Lidholm, J., Änggård, A., Hökfelt, T., Lundberg, J.M. & Alving, K. 1995. High nitric oxide production in human paranasal sinuses. Nature Med 1(4), 370-373.
27. Lundblad, L., Lundberg, J.M., Brodin, L. & Änggård, A. 1983. Origin and distribution of capsaicin-sensitive substance P-immunoreactive nerves in the nasal mucosa. Acta Otolaryngol 96, 485-493.
28. 2+-dependently convets L-arginine into an activator of soluble guanylyl cyclase. Biochem Biophys Res Commun 164(2), 678-685.
29. Mitchell, J.A., de Nucci, G., Warner, T.D. & Vane, J.R. 1991. Alkaline buffers release EDRF from bovine cultured aortic endothelial cells. Br J Pharmacol 103, 1245-1302.
30. Modin, A., Weitzberg, L. & Lundberg, J.M. 1994. Nitric oxide regulates peptide release from parasympathetic nerves and vascular reactivity to vasoactive intestinal polypeptide in vivo. Eur J Pharmacol 261, 185-197.
31. Moncada, S., Palmer, R.M.J. & Higgs, K.A. 1991. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 43(2), 109-142.
32. Mügge, A., Lopez, J.A.G., Piegors, D.J., Breese, K.R. & Heistad, D.D. 1991. Acetylcholine-induced vasodilatation in rabbit hindlimb in vivo is not inhibited by analogues of L-arginine. Am J Physiol 260 (Heart Circ Physiol 29), H242-H247.
33. Nathan, C. & Xie, Q.-W. 1994a. Nitric oxide synthases: roles, tolls, and controls. Cell 78, 915-918.
34. Nathan, C. & Xie, Q.-W. 1994b. Regulation of biosynthesis of nitric oxide. J Biol Chem 269, 13725-13728.
35. Palmer, R.M.J., Ferrige, A.G. & Moncada, S. 1987. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327, 524-526.
36. Palmer, R.M.J. & Moncada, S. 1989. A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells. Biochem Biophys Res Commun 158(1), 348-352.
37. Palmer, R.M.J., Rees, D.D., Ashton, D.D. & Moncada, S. 1988. L-Arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation. Biochem Biophys Res Commun 153, 1251-1256.
38. Rees, D.D., Palmer, R.M.J., Hodson, H.F. & Moncada, S. 1989. A specific inhibitor of nitric oxide formation from L-arginine attenuates endothelium-dependent relaxation. Br J Pharmacol 96, 418-424.
39. ω-nitro-L-arginine-compared to α-adrenoceptor agonist-mediated vascular effects in the pig nasal mucosa in vivo. Abstract Congress of Pharmacology, July 24-29, Montreal, Canada.
40. 1-receptor antagonist SR 140.333 on capsaicin-evoked vasodilation in the pig nasal mucosa in vivo. Acta Physiol Scand 156, 115-122.
41. Saria, A., Theodorsson-Norheim, E., Gamse, R. & Lundberg, J.M. 1984. Release of substance P- and substance K-like immunoreactivities from the isolated perfused guinea-pig lung. Eur J Pharmacol 106, 207-208.
42. Stark, R.D. 1968. Conductance or resistance? Nature 217, 779.
43. Stjärne, P., Lacroix, J.S., Änggard, A. & Lundberg, J.M. 1991a. Release of calcitonin gene-related peptide in the pig nasal mucosa by antidromic nerve stimulation and capsaicin. Regul Pept 33, 251-262.
44. Stjärne, P., Lacroix, J.S., Änggård, A. & Lundberg, J.M. 1991b. Compartment analysis of vascular effects of neuropeptides and capsaicin in the pig nasal mucosa. Acta Physiol Scand 141, 235-242.
45. Sütsch, G., Saeed, M. & Hing, R.J. 1988. Uncertain role of endothelium-derived relaxing factor in mesenteric arterioles of cats and rabbits. Artery 15, 176-191.
46. Toda, N., Kitamura, Y. & Okamura, T. 1993. Neural mechanism of hypertension by nitric oxide synthase inhibitor in dogs. Hypertension 21, 3-8.
47. Watanabe, H., Tsuru, H., Kawamoto, H., Yajin, K., Sasa, M. & Harada, Y. 1995. Nitroxidergic vasodilator nerve in the canine nasal mucosa. Life Sci 57, PL 109-112.
48. Whittle, B.J.R., Lopez-Belmonte, J. & Rees, D.D. 1989. Modulation of the vasodepressor actions of acetylcholine, bradykinin, substance P and endothelin in the rat by a specific inhibitor of nitric oxide formation. Br J Pharmacol 98, 646-652.