Postnatal development of the pattern of respiratory and cardiovascular response to systemic hypoxia in the piglet: The roles of adenosine

Journal of Physiology

Volumn 492, Issue 2, 1996, Pages 573-585

  Elnazir, Basil ^a,b   Marshall, Janice M ^a   Kumar, Prem ^a  

^a UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

^b Pathology Research Laboratory   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLOROADENOSINE; 8 PHENYLTHEOPHYLLINE; ADENOSINE; ADENOSINE DERIVATIVE; ALTHESIN;

ANIMAL EXPERIMENT; ARTERIAL PRESSURE; ARTICLE; BLOOD GAS; BLOOD PH; BREATHING; BREATHING RATE; CARDIOVASCULAR RESPONSE; CONTROLLED STUDY; FEMORAL ARTERY FLOW; HEART RATE; HYPOXIA; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY BLOOD FLOW; KIDNEY BLOOD VESSEL; LUNG MINUTE VOLUME; MEAN ARTERIAL PRESSURE; NEWBORN; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; RESPIRATORY SYSTEM; SKELETAL MUSCLE; SWINE; TACHYCARDIA; VASOCONSTRICTION; VASODILATATION;

EID: 0029870469     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.1996.sp021330     Document Type: Article

References (45)

1. BUCKLEY, N. M., BRAZEAU, P. & GOOTMAN, P. M. (1983). Mataration of circulatory responses to adrenergic stimuli. Federation Proceedings 42, 1643-1647.
2. DALY, M. DE BURGH (1986). Interactions between respiration and circulation. In Handbook of Physiology, section 3, The Respiratory System, vol II, part 2, ed. CHERNIACK, N. S. & WIDDICOMBE, J. G., pp. 529-594. American Physiological Society, Bethesda, MD, USA.
3. DARNALL, R. A. (1985). Aminophylline reduces hypoxic ventilatory depression: possible role of adenosine. Pediatric Research 19, 706-710.
4. DARNALL, R, A., GREEN, G., PINTO, L. & HART, N. (1991). Effect of acute hypoxia on respiration and brain-stem blood flow in the piglet. Journal of Applied Physiology 70, 251-259.
5. DOWNING, D. E., MITCHELL, J. H. & WALLACE, A. G. (1963). Cardiovascular responses to ischaemia, hypoxia and hypercapnia of the central nervous system. American Journal of Physiology 204, 881-887.
6. EASTON, P. A. & ANTHONISEN, N. R. (1988). Ventilatory response to sustained hypoxia after pretreatment with aminophylline. Journal of Applied Physiology 64, 1445-1450.
7. FROLDI, G. & BELARDINELLI, L. (1990). Species-dependent effects of adenosine on heart rate and atrio ventricular nodal conduction-mechanism and physiological implications. Circulation Research 67, 960-978.
8. GOOTMAN, P. M. (1991). Developmental aspects of reflex control of the circulation. In Reflex Control of the Circulation, ed. ZUCKER, I. H. & GILMORE, J. P., pp. 965-1027. Telford Press, Calwell, NJ, USA.
9. GOOTMAN, P. M., BUCKLEY, N. M. & GOOTMAN, N. (1979). Postnatal development of neural control of circulation. In Review in Perinatal Medicine, ed. SCARPELLI, E. M. & COSMI, E. V., vol. 3, pp. 1-92. Raven Press, New York.
10. GOOTMAN, P. M., GANDHI, M. R., STEELE, A. M., HUNDLEY, B. W., COHEN, H. L., EBERLE, L. P. & SICA, A. L. (1991). Respiratory modulation of sympathetic activity in neonatal swine. American Journal of Physiology 261, R1147-1154.
11. GOOTMAN, P. M., GOOTMAN, N., BUCKLEY, B. J., PETERSON, B. J., STEELE, A. M., SICA, A. L. & GANDHI, M. R. (1990). Effects of hypoxia in developing swine. In Chemoreceptors and Chemoreceptor Reflexes, ed. ACKER, H., TRZEBSKI, A. & O'REGAN, R. G., pp. 15-163. Plenum Press, New York.
12. GOUYON, J. B. & GUIGNARD, J. P. (1988). Theophylline prevents the hypoxemia-induced renal haemodynamic changes in newborn and adult rabbits. Kidney International 33, 1078-1083.
13. GREEN, C. J. (1979). Animal Anaesthesia. Laboratory Animals Ltd, London.
14. HANSON, M. A. (1986). Peripheral chemoreceptor functions before and after birth. In Reproductive and Perinatal Medicine (III), Respiratory Control and Lung Development in the Fetus and Newborn, ed. JOHNSON, B. M. & GLUCKMAN, P. D., pp. 311-330. Perinatology Press, Ithaca, XY, USA.
15. HILTON, S. M. & MARSHALL, J. M. (1982). The pattern of cardiovascular response to carotid chemoreceptor stimulation in the cat. Journal of Physiology 326, 495-513.
16. LAUDIGNON, N., ARANDA, J. V. & VARMA, D. R. (1990). Effects of adenosine and its analogues on isolated internal carotid arteries from newborn and adult pigs. Biology of the Neonate 58, 91-97.
17. LAUDIGNON, N., FARRI, E., BEHARRY, K., REX, J. & ARANDA, J. V. (1991). Influence of adenosine on cerebral blood flow during hypoxie hypoxia in the newborn piglet. Journal of Applied Physiology 68, 1534-1541.
18. LAWSON, E. E. & LONG, W. A. (1983). Central origin of biphasic breathing pattern during hypoxia in newborns. Journal of Applied Physiology 55, 483-488.
19. MCQUEEN, D. S. & RIBEIRO, J. A. (1983). On the specificity and type of receptor involved in carotid body chemoreceptor activation by adenosine in the cat. British Journal of Physiology 80, 347-354.
20. MARSHALL, J. M. (1987). Analysis of cardiovascular responses evoked following changes in chemoreceptor activity in the rat. Journal of Physiology 394, 393-415.
21. MARSHALL, J. M. (1994). Peripheral chemoreceptors and cardiovascular regulation. Physiological Reviews 74, 543-594.
22. MARSHALL, J. M. (1995). Skeletal muscle vasculature and hypoxia. News in Physiological Sciences 10, 274-280.
23. MARSHALL, J. M. & METCALFE, J. D. (1988a). Cardiovascular changes associated with augmented breaths in normoxia and hypoxia in the rat, Journal of Physiology 400, 15-27.
24. MARSHALL, J. M. & METCALFE, J. D. (1988b). Analysis of the cardiovascular changes induced in the rat by graded levels of systemic hypoxia. Journal of Physiology 407, 383-403.
25. MARSHALL, J. M. & METCALFE, J. D. (1989). Analysis of factors that contribute to cardiovascular changes induced in the cat by graded levels of systemic hypoxia. Journal of Physiology 412, 429-448.
26. + channels and muscle vasodilatation in the rat in systemic hypoxia. Journal of Physiology 459, 1-9.
27. MIAN, R. & MARSHALL, J. M. (1991). The role of adenosine in dilator responses induced in arterioles and venules of rat skeletal muscle in systemic hypoxia. Journal of Physiology 493, 499-511.
28. MILERAD, J. (1987). Effects of theophylline on ventilatory responses to hypoxic challenge. Archives of Diseases in Childhood 62, 1242-1246.
29. MILLHORN, D. E., ELDRIDGE, F. L., KILEY, J. P. & WALDROP, T. G. (1984). Prolonged inhibition of respiration following acute hypoxia in glomectomised cats. Respiration Physiology 57, 331-340.
30. MOSS, I. R., RUNOLD, M., DAHLIN, I., FREDHOLM, B. B., NYBERG, K. & LAGERCRANTZ, H. (1987). Respiratory and neuroendocrine responses of piglets to hypoxia during postnatal development. Acta Physiologica Scandinavica 131, 533-541.
31. NEYLON, M. & MARSHALL, J. M. (1991). The role of adenosine in the respiratory and cardiovascular response to systemic hypoxia in the rat. Journal of Physiology 440, 529-545.
32. OLSSON, R. A. & PEARSON, J. D. (1990). Cardiovascular purinoceptors. Physiological Reviews 70, 761-845.
33. ROSEN, C. L., SCHECTER, W. S., MELLINS, R. B. & HADDAD, G. G. (1993). Effects of acute hypoxia on metabolism and ventilation in awake piglets. Respiration Physiology 91, 307-319.
34. RUNOLD, M., LAGERCRANTZ, N., PRABHAKAR, N. R. & FREDHOLM, B. B. (1989). Role of adenosine in hypoxia ventilatory depression. Journal of Applied Physiology 67, 541-546.
35. SIDI, D., KUIPERN, J. R. G., TEITEL, D., HEYMANN, M. A. & RUDOLPH, A. M. (1983). Developmental changes in oxygenation and circulatory responses to hypoxemia in lambs. American Journal of Physiology 245, H674-682.
36. SMELLIE, F. W., DAVIS, C. W., DALY, J. W. & WELLS, J. N. (1979). Alkylxanthines: inhibition of adenosine-elicited accumulation of cyclic AMP in brain slices and brain phosphodiesterase activity. Life Sciences 24, 2475-2482.
37. SPIELMAN, W. S. & THOMPSON, C. I. (1982). A proposed role for adenosine in the regulation of renal haemodynamics and renin release. American Journal of Physiology 242, F423-435.
38. THOMAS, T., ELNAZIR, B. & MARSHALL, J. M. (1994). Differentiation of the peripherally mediated from the centrally mediated influences of adenosine in the rat during systemic hypoxia. Experimental Physiology 79, 809-822.
39. THOMAS, T. & MARSHALL, J. M. (1994). Interdependence of respiratory and cardiovascular changes induced by systemic hypoxia in the rat: the roles of adenosine. Journal of Physiology 480, 627-636.
40. THOMAS, T. & MARSHALL, J. M. (1995). A study on rats of the effects of chronic hypoxia from birth on respiratory and cardiovascular responses evoked by acute hypoxia. Journal of Physiology 487, 513-525.
41. TIMMS, R. J. (1981). A study of the amygdaloid defence reaction showing the value of Althesin anaesthesia in studies of the functions of the fore-brain in cats. Pflügers Archiv 391, 49-56.
42. VERLATO, G. & BORGDORFF, P. (1990). Endogenous adenosine enhances vagal negative chronotropic effect during hypoxia in the anaesthetised rabbit. Cardiovascular Research 24, 532-539.
43. WILLIAMS, M. (1989). Adenosine antagonists. Medical Research Reviews 9, 219-243.
44. WINN, H. R., RUBIO, R. & BERNE, R. M. (1981). Brain adenosine concentration during hypoxia in rats. American Journal of Physiology 241, H235-242.
45. ZIMMERMAN, H. (1994). Signalling via ATP in the nervous system. Trends in Neurosciences 17, 420-426.