Expression of bak in S. pombe results in a lethality mediated through interaction with the calnexin homologue Cnx1

Cell Death and Differentiation

Volumn 4, Issue 4, 1997, Pages 263-271

  Torgler, Catherine N ^a   De Tiani, Mariastella ^a   Raven, Thomas ^b   Aubry, Jean Pierre ^a   Brown, Robin ^b   Meldrum, Eric ^a  

^a GLAXOSMITHKLINE   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Apoptosis; bak; bcl 2 family; Calnexin; Programmed cell death; Schizosaccharomyces pombe

Indexed keywords

CALNEXIN; CELL PROTEIN; PROTEIN BAK; PROTEIN BAX; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL DEATH; CONTROLLED STUDY; ETIOLOGY; GENE EXPRESSION; GENETIC ANALYSIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SCHIZOSACCHAROMYCES POMBE; SEQUENCE HOMOLOGY;

EID: 0031009968     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400239     Document Type: Article

References (33)

1. Ameisen JC (1996) The origin of programmed cell death. Science 272: 1278 - 1279
2. Ameisen JC, Idziorek T, Billaut-Mulot O, Loyens M , Tissier JP, Potentier A, and Ouaissi A (1995) Apoptosis in a unicellular eukaryote (Trypanosoma cruzi): implications for the evolutionary origin and role of programmed cell death in the control of cell proliferation, differentiation and survival. Cell Death Differ. 2: 285 - 300
3. Bergeron JJM, Brenner MB, Thomas DY, and Williams DB (1994) Calnexin: a membrane bound chaperone of the endoplasmic reticulum. Trends Biochem. Sci. 19: 124 - 128
4. Chen-Levy Z, Nourse J, and Cleary ML (1989) The bcl-2 candidate proto-oncogene product is a 24-kilodalton integral-membrane protein highly expressed in lymphoid cell lines and lymphomas carrying the t(14,18) translocation. Mol. Cell Biol 9: 701 - 710
5. Chittenden T, Harnngton EA, O'Conner R, Flemington C, Lutz RJ, Evan GI, and Guild BC (1995) Induction of apoptosis by the bcl-2 homologue bak. Nature 374: 733 - 736
6. Clarke PGH (1990) Developmental cell death: morphological diversity and multiple mechanisms. Anat Embryol. 181. 195 - 213
7. Cornillon S, Foa C, Davoust J, Buonavista N, Gross JD, and Golstein P (1994) Programmed cell death in Dictyostelium. J. Cell Sci. 107: 2691 - 2704
8. Elder RT, Loh EY, and Davis RW (1983) RNA from the yeast transposable element ty 1 has both ends in the direct repeats, a structure similar to retrovirus RNA. Proc. Natl. Acad. Sci. USA 80. 2432 - 2436
9. Ellis RE, Yuan J, and Horvitz RH (1991) Mecanisms and functions of cell death. Annu. Rev Cell Biol. 7 663 - 698
10. Farrow SN and Brown R (1996) New members of the Bcl-2 family and their protein partners. Curr. Op. Gen. Dev 6: 45 - 49
11. Farrow SN, White JHM, Martinou I, Raven T, Pun KT, Grinham CJ, Martinou JC, and Brown R (1995) Cloning of a bcl-2 homologue by interaction with adenovirus E1B19K. Nature 374: 731 - 733
12. Garcia I, Martinou I, Tsujimoto Y, and Martinou JC (1992) Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene Science 258: 302 - 304
13. Gonzalez-Garcia M, Perez-Ballestro R, Ding L, Duan L, Boise LH, Thompson CB, and Nunez G (1994) bcl-XL is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria. Development 120: 3033 - 3042
14. Hengartner MO and Horvitz HR (1994) C elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2. Cell 74: 665 - 676
15. Jacobson MD, Bume JF, King NP, Miyashita T, Reed JC, and Raff MC (1993) Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA Nature 361: 365 - 369
16. Kiefer MC, Brauer MJ, Powers VC, Wu JJ, Umansky SR, Tomei LD, and Barr PJ (1995) Modulation of apoptosis by the widely distributed Bcl-2 homologue Sak Nature 374 736 - 739
17. Korsmeyer SJ, Shutter JR, Veis DJ, Merry DE, and Oltvai ZN (1993) Bcl-2/Bax a rheostat that regulates an anti-oxidant pathway and cell death. Sem. Cancer Biol 4. 327 - 332
18. Krajewski S, Tanaka S, Takayama S, Schibler MJ, Fenton W, and Reed JC (1993) Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. Cancer Res. 53: 4701 - 4714
19. Maundrell K (1990) nmt1 of Fission Yeast. J. Biol Chem. 265: 10857 - 10864
20. Maundrell K (1993) Thiamine-repressible expression vectors pPREP and pRIP for fission yeast. Gene 123: 127 - 130
21. Moreno S, Klar A, and Nurse P (1991) Molecular genetic analysis of fission yeast, S. pombe. Meth Enzymol 194: 795 - 823
22. Morgan DO (1995) Pnnciples of CDK regulation. Nature 374: 131 - 134
23. Motoyama N, Wang F, Roth KA, Sawa H, Nakayama KI, Nakayama K, Negishi I, Senju S, Zhang Q, Fujii S, and Loh DY (1995) Massive cell death of immature hematopoietic cells and neurons in bcl-x-deficient mice Science 267: 1506 - 1510
24. Oltvai ZN and Korsmeyer SJ (1994) Checkpoints of dueling dimers foil death wishes. Cell 79: 189 - 192
25. Oltvai ZN, Milliman CL, and Korsmeyer SJ (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death Cell 74: 609 - 619
26. + in 3. pombe is an essential gene which can be complimented by its soluble ER domain. EMBO J 14: 3064 - 3072
27. Reed JC (1994) Bcl-2 and the regulation of programmed cell death. J. Cell Biol. 124: 1 - 6
28. Robertson AMG and Thomson JN (1982) Morphology of programmed death in the ventral nerve cord of Caenorhabditis elegans larvae J. Embryol Exp. Morph 67: 89 - 100
29. Sambrook J, Fritsch EF and Maniatis T (1989) Molecular cloning. a laboratory manual, 2nd ed. (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York)
30. Veis DJ, Sorenson CM, Shutter JR, and Korsmeyer SJ (1993) Bcl-2 deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys and hypopigmented hair. Cell 75: 229 - 240
31. Wellbum SC, Dale C, Ellis D, Beecroft R, and Pearson TW (1996) Apoptosis in procyclic Trypanosoma brucei rhodesiense in vitro. Cell Death Differ 3. 229 - 236
32. Williams GT and Smith CA (1993) Molecular regulation of apoptosis genetic controls on cell death. Cell 74: 777 - 779
33. Zhu W, Cowie A, Wasfy GW, Penn LZ, Leber B, and Andrews DW (1996) Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types. The EMBO Journal 15: 4130 - 4141