Is Hypertriglyceridemia a Risk Factor for Atherosclerotic Cardiovascular Disease? A Simple Question with a Complicated Answer

Annals of Internal Medicine

Volumn 126, Issue 11, 1997, Pages 912-914

  Ginsberg, Henry N ^a,b  

^a NEW YORK UNIVERSITY   (United States)

^b College of Physicians and Surgeons of Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

BLOOD CLOTTING; CORONARY ARTERY ATHEROSCLEROSIS; EDITORIAL; EDUCATION PROGRAM; FIBRINOLYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERTRIGLYCERIDEMIA; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RISK FACTOR;

CORONARY ARTERIOSCLEROSIS; HUMANS; HYPERTRIGLYCERIDEMIA; RISK FACTORS;

EID: 0031009885     PISSN: 00034819     EISSN: None     Source Type: Journal    
DOI: 10.7326/0003-4819-126-11-199706010-00012     Document Type: Article

References (20)

1. Hully SB, Rosenman RH, Bawol RD, Brand RJ. Epidemiology as a guide to clinical decisions. The association between triglycéride and coronary heart disease. N Engl J Med. 1980:302:1383-9.
2. Austin MA. Plasma triglycéride and coronary heart disease. Arterioscler Thromb. 1991;11:2-14.
3. Ginsberg HN. Lipoprotein metabolism and its relationship to atherosclerosis. Med Clin North Am. 1994;78:1-20.
4. Hamsten A. Hypertriglyceridemia, triglyceride-rich lipoproteins and coronary heart disease. Baillieres Clin Endocrinol Metabol. 1990;4:895-922.
5. Daugherty A, Lange LG, Sobel BE, Schonfeld G. Aortic accumulation and plasma clearance of beta-VLDL and HDL: effects of diet-induced hypercholesterolemia in rabbits. J Lipid Res. 1985:26:955-63.
6. Rapp JH, Lespine A, Hamilton RL, Colyvas N, Chaumeton AH, Tweedle-Hardman J, et al. Triglyceride-rich lipoproteins isolated by selected-affinity anti-apolipoprotein B immunosorption from human atherosclerotic plaque. Arterioscler Thromb. 1994;14:1767-74.
7. Breslow JL Mouse models of atherosclerosis. Science. 1996:272:685-8.
8. Miller NE. High-density lipoprotein: a major risk factor for coronary atherosclerosis. Baillieres Clin Endocrinol Metabol. 1987:1:603-22.
9. Plump AS, Scott Q, Breslow JL. Human apolipoprotein A-l gene expression increases high density lipoprotein and suppresses atherosclerosis in the apolipoprotein E-deficient mouse. Proc Natl Acad Sei USA. 1994:91:9607-11.
10. Liu AC, Lawn RM, Verstuyft JG. Rubin EM. Human apolipoprotein A-l prevents atherosclerosis associated with apolipoprotein[a] in transgenic mice. J Lipid Res. 1994:35:2263-7.
11. Tall AR. Plasma high density lipoproteins. Metabolism and relationship to atherogenesis. J Clin Invest. 1990:86:379-84.
12. Ginsberg HN, Jones J. Blaner WS, Thomas A, Karmally W, Fields L, et al. Association of postprandial triglycéride and retinyl palmitate responses with newly diagnosed exercise-induced myocardial ischemia in middle-aged men and women. Arterioscler Thromb Vase Biol. 1995:15:1829-38.
13. Sharrett AR, Chambless LE, Heiss G, Paton CC, Patsch W. Association of postprandial triglycéride and retinyl palmitate responses with asymptomatic carotid artery atherosclerosis in middle-aged men and women. The Atherosclerosis Risk in Communities (ARIC) Study. Arterioscler Thromb Vase Biol. 1995:15:2122-9.
14. National Cholesterol Education Program. Second report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II). Circulation. 1994:89:1333-445.
15. Frick MH. Elo H. Haapa K, Heinonen OP, Henisalmi P, Helo P. et al. Helsinki Heart Study: primary-prevention trial with gemfibrozil in middle-age men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease. N Engl J Med. 1987:317:1237-45.
16. Carlson LA, Rosenhamer G. Reduction in mortality in the Stockholm Ischaemic Heart Disease Secondary Prevention Study by combined treatment with clofibrate and nicotinic acid. Acta Med Scand. 1988:223:405-18.
17. Manninen V, Tenkanen L, Koskinen P, Huttunen JK, Manttari M, Heinonen O, et al. Joint effects of serum triglycéride and LDL cholesterol and HDL cholesterol concentrations on coronary heart disease risk in the Helsinki Heart Study. Implications for treatment. Circulation. 1992:85:37-45.
18. Assmann G, Schulte H. Relation of high-density lipoprotein cholesterol and triglycérides to incidence of atherosclerotic coronary artery disease (the PROCAM experience). Prospective Cardiovascular Munster Study. Am J Cardiol. 1992:70:733-7.
19. Despres JP, Lamarche B, Mauriege P, Cantin B, Oagenais GR, Moorj'ani S, et al. Hyperinsulinemia as an independent risk factor for ischémie heart disease. N Engl J Med. 1996:334:952-7.
20. Wilt TJ. Rubins HB. Collins D, O'Connor TZ, Rutan GH, Robins SJ. Correlates and consequences of diffuse atherosclerosis in men with coronary heart disease. Veterans Affairs High-Density Lipoprotein Intervention Trial Study Group. Arch Intern Med. 1996:156:1181-8.