Epitope spreading leads to myelin-specific autoimmune responses in SJL mice chronically infected with Theiler's virus

Journal of NeuroVirology

Volumn 3, Issue SUPPL. 1, 1997, Pages

  Miller, Stephen D ^a   Vanderlugt, Carol L ^a   Begolka, Wendy Smith ^a   Pao, Winnie ^a   Neville, Katherine L ^a   Yauch, Robert L ^a   Kim, Byung S ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Autoimmunity; Epitope spreading; Myelin; Proteolipid protein; Theiler's virus

Indexed keywords

EPITOPE; GAMMA INTERFERON; MYELIN PROTEIN; NITRIC OXIDE; PROTEOLIPID PROTEIN; TUMOR NECROSIS FACTOR;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AUTOIMMUNITY; CONFERENCE PAPER; CONTROLLED STUDY; DEMYELINATING DISEASE; DEMYELINATION; ETIOLOGY; MOUSE; MULTIPLE SCLEROSIS; MURINE ENCEPHALOMYELITIS VIRUS; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANIMALS; AUTOIMMUNITY; DEMYELINATING DISEASES; EPITOPES; MICE; MICE, INBRED STRAINS; MODELS, IMMUNOLOGICAL; MODELS, NEUROLOGICAL; MYELIN SHEATH; POLIOMYELITIS; T-LYMPHOCYTES; THEILOVIRUS;

EID: 0031009372     PISSN: 13550284     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (22)

1. Barbano RL, Dal Canto MC (1984). Serum and cells from Theiler's virus-infected mice fail to injure myelinating cultures or to produce in vivo transfer of disease. The pathogenesis of Theiler's virus-induced demyelination appears to differ from that of EAE. J Neurol Sci 66: 283-293.
2. Clatch RJ, Melvold RW, Miller SD, Lipton HL (1985). Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease in mice is influenced by the H-2D region: correlation with TMEV-specific delayed-type hypersensitivity. J Immunol 135: 1408-1414.
3. Clatch RJ, Lipton HL, Miller SD (1986). Characterization of Theiler's murine encephalomyelitis virus (TMEV)-specific delayed-type hypersensitivity responses in TMEV-induced demyelinating disease: correlation with clinical signs. J Immunol 136: 920-927.
4. Clatch RJ, Lipton HL, Miller SD (1987). Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. II. Survey of host immune responses and central nervous system virus titers in inbred mouse strains. Microb Pathogen 3: 327-337.
5. Clatch RJ, Miller SD, Metzner R, Dal Canto MC, Lipton HL (1990). Monocytes/macrophages isolated from the mouse central nervous system contain infectious Theiler's murine encephalomyelitis virus (TMEV). Virol 176: 244-254.
6. Dal Canto MC, Melvold RW, Kim BS, Miller SD (1995). Two models of multiple sclerosis: Experimental allergic encephalomyelitis (EAE) and Theiler's murine encephalomyelitis virus (TMEV) infection - a pathological and immunological comparison. Microsc Res Tech 32: 215-229.
7. Dal Canto MC, Lipton HL (1975). Primary demyelination in Theiler's virus infection. An ultrastructural study. Lab Invest 33: 626-637.
8. Gauntt CJ (1988). The possible role of viral variants in pathogenesis. In: Infectious Agents and Pathogenesis. Friedman H, Bendinelli M (eds). Plenum Publishing Corp: New York, pp. 159-179.
9. + T cell line specific for an immunodominant VP2 epitope. J Immunol 152: 919-929.
10. Karpus WJ, Pope JG, Peterson JD, Dal Canto MC, Miller SD (1995). Inhibition of Theiler's virus-mediated demyelination by peripheral immune tolerance induction. J Immunol 155: 947-957.
11. Kurtzke JF (1993). Epidemiologic evidence for multiple sclerosis as an infection. Clin Microbiol Rev 6: 382-427.
12. Lehrich JR, Arnason BGW, Hochberg F (1976). Demyelinative myelopathy in mice induced by the DA virus. J Neurol Sci 29: 149-160.
13. Lipton HL (1975). Theiler's virus infection in mice: An unusual biphasic disease process leading to demyelination. Infect Immun 11: 1147-1155.
14. Lipton HL, Kratochvil J, Sethi P, Dal Canto MC (1984). Theiler's virus antigen detected in mouse spinal cord 2 1/2 years after infection. Neurology 34: 1117-1119.
15. McRae BL, Vanderlugt CL, Dal Canto MC, Miller SD (1995). Functional evidence for epitope spreading in the relapsing pathology of EAE in the SJL/J mouse. J Exp Med 182: 75-85.
16. Miller SD, Clatch RJ, Pevear DC, Trotter JL, Lipton HL (1987). Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. I. Cross-specificity among TMEV substrains and related picornaviruses, but not myelin proteins. J Immunol 138: 3776-3784.
17. Miller SD, Gerety SJ, Kennedy MK, Peterson JD, Trotter JL, Tuohy VK, Waltenbaugh C, Dal Canto MC, Lipton HL (1990). Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. III. Failure of neuroantigen-specific immune tolerance to affect the clinical course of demyelination. J Neuroimmunol 26: 9-23.
18. Miller SD, McRae BL, Vanderlugt CL, Nikcevich KM, Pope JG, Pope L, Karpus WJ (1995). Evolution of the T cell repertoire during the course of experimental autoimmune encephalomyelitis. Immunol Rev 144: 225-244.
19. + T cell-mediated pathology. J Immunol 156: 4050-4058.
20. Rose NR, Herskowitz A, Neumann DA (1993). Autoimmunity in myocarditis: models and mechanisms. Clin Immunol Immunopathol 68: 95-99.
21. Waksman BH (1995). Multiple sclerosis: More genes versus environment. Nature 377: 105-106.
22. Wekerle H (1991). Immunopathogenesis of multiple sclerosis. Acta Neurologica 13: 197-204.