The first asymmetric synthesis of the naturally occurring (+)-Kotanin and the assignment of its absolute configuration

Tetrahedron Asymmetry

Volumn 8, Issue 9, 1997, Pages 1369-1372

  Lin, Guo Qiang ^a   Zhong, Min ^a  

^a SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

COUMARIN DERIVATIVE; KOTANIN; UNCLASSIFIED DRUG;

CIRCULAR DICHROISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; IN VITRO STUDY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; REACTION ANALYSIS; SHORT SURVEY;

EID: 0031006564     PISSN: 09574166     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0957-4166(97)00117-1     Document Type: Article

References (17)

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6. Lipshutz, B. H.; Kayser, F; Liu, Z.-P., Angew. Chem. Int. Ed. Engl., 1994, 33, 1842 and references cited therein.
7. exl 297 nm (Δ∈ +3.38), 275 (Δ∈ -2.03), 240 (Δ∈ +3.78), 235 (Δ∈ +2.43), 230 (Δ∈ +3.78), 211 (Δ∈ -6.21).
8. Mash, E. A.; Nelson, K. A.; Densen, E. V.; Hemperly, S. B., Org. Synth., Coll. Vol. VIII; John Wiley and Sons. Inc.: New York, 1993: p. 155.
9. 2-Bromo-3-methoxy-5-methylphenol was synthesized according to the following lit.: a. Mirrington, R. N.; Feutrill, G. I. Org. Synth., Coll. Vol. IV; John Wiley and Sons. Inc., New York, 1993: p. 155.
10. b. Cannon, J. R.; Cresp, T. M.; Metcalf, B. W.; Sargent, M. V; Vinciguerra, G.; Elix, J. A., J. Chem. Sos. (C), 1971, 3495.
11. c. Feutrill, G. I.; Mirrington, R. N., Aust. J. Chem., 1972, 25, 1719.
12. 2: C, 58.30; H, 5.18. Found: C, 58.49; H, 5.32.
13. +): 540.2513, found 540.2475.
14. 4: C, 70.06; H, 6.61. Found: C, 69.95; H, 6.65.
15. 6: C, 67.03; H, 6.18. Found: C, 67.32; H, 6.18.
16. +): 438.1315, found 438.1342.
17. Lin, G.-Q.; Zhong, M., Tetrahedron Lett., 1996, 37. 3015.