Influence of substituents in fluorobenzene derivatives on the cytochrome P450-catalyzed hydroxylation at the adjacent ortho aromatic carbon center

Chemical Research in Toxicology

Volumn 10, Issue 3, 1997, Pages 279-288

  Koerts, Janneke ^a   Velraeds, Martine M C ^a   Soffers, Ans E M F ^a   Vervoort, Jacques ^a   Rietjens, Ivonne M C M ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC HYDROCARBON; BENZENE DERIVATIVE; BROMINE; CARBON; CHLORINE; CYTOCHROME P450; FLUOROBENZENE; IODINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HYDROXYLATION; LIVER METABOLISM; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; RAT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; BIOTRANSFORMATION; CHEMISTRY, PHYSICAL; CYTOCHROME P-450 ENZYME SYSTEM; FLUOROBENZENES; HYDROXYLATION; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICROSOMES, LIVER; PHENOLS; RATS; RATS, WISTAR;

EID: 0031004840     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx960048j     Document Type: Article

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