Interaction between the substrate and the high-valent-iron-oxo porphyrin cofactor as a possible factor influencing the regioselectivity of cytochrome P450 catalysed aromatic ring hydroxylation of 3-fluoro(methyl)anilines

Chemico-Biological Interactions

Volumn 99, Issue 1-3, 1996, Pages 129-146

  Koerts, Janneke ^a   Boeren, Sjef ^a   Vervoort, Jacques ^a   Weiss, Raymond ^b   Veeger, Cees ^a   Rietjens, Ivonne M C M ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

3 Fluoro (methyl)anilines; Aromatic ring hydroxylation; Cytochrome P450; Microperoxidase 8; Molecular orbital calculations

Indexed keywords

ANILINE DERIVATIVE; CYTOCHROME P450; PEROXIDASE;

ANIMAL TISSUE; ARTICLE; BINDING SITE; CATALYSIS; CONTROLLED STUDY; HYDROXYLATION; MALE; NONHUMAN; RAT; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION; XENOBIOTIC METABOLISM;

ANILINE COMPOUNDS; ANILINE HYDROXYLASE; ANIMALS; BINDING SITES; CYTOCHROME P-450 ENZYME SYSTEM; FLUOROBENZENES; HYDROXYLATION; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICROSOMES; MOLECULAR STRUCTURE; RATS; RATS, WISTAR; SUBSTRATE SPECIFICITY;

ANIMALIA;

EID: 0029671314     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/0009-2797(95)03664-4     Document Type: Article

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