Transcriptional activation by 1,25-Dihydroxyvitamin D3 and synthetic vitamin D3 Analogues in transfected cultures of human keratinocytes

Skin Pharmacology and Physiology

Volumn 10, Issue 1, 1997, Pages 11-20

  Henriksen, Linda Ø ^a,b   Kragballe, Knud ^a   Jensen, Thomas G ^b   Fogh, Karsten ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

Human keratinocytes; Transcriptional activation; Vitamin D receptor; Vitamin D3; Vitamin D3 analogues

Indexed keywords

ALITRETINOIN; CALCIPOTRIOL; CALCITRIOL; CHLORAMPHENICOL ACETYLTRANSFERASE; COLECALCIFEROL DERIVATIVE; EB 1213; GS 1500; LEXACALCITOL; RETINOID X RECEPTOR; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INDUCTION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; KERATINOCYTE; MOLECULAR CLONING; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PSORIASIS; REPORTER GENE; TRANSCRIPTION REGULATION;

EID: 0031004256     PISSN: 16605527     EISSN: 16605535     Source Type: Journal    
DOI: 10.1159/000211455     Document Type: Article

References (36)

1. Smith EL, Walworth NC, Holick MF: Effect of 1.25-dihvdroxyvita-min Dj on the morphologic and biochemical differentiation of cultures human epidermal kératinocytes grown in serum-free conditions. J Invest Dermatol I986;86: 706-716.
2. Kragballe K, Wildfang I-L: Calcipo-triol (MC 903). a novel vitamin D3 analogue, stimulates terminal differentiation and inhibits proliferation of cultured human keratinocvtes. Arch Dermatol Res 1990:282:164-167.
3. Kragballe K: Treatment of psoriasis by the topical application of the novel cholccalciferol analogue calcipo-triol (MC 903). Arch Dermatol 1989:125:1647-1652.
4. Kragballe K, Ivcrsen L: Calcipotriol (MC 903) a new topical antipsoriatic. Dermatol Clin 1993:11:137-141.
5. Green C, Ganpulc M, Harris D, Kavanagh G, Kennedy C, Mallclt R, Rustin M, Downes N: Comparative effects of calcipotriol (MC 903) solution and placebo (vehicle of MC 903) in the treatment of psoriasis of the scalp. Br J Dermatol 1994; 130: 483-487.
6. Pillai S, Bikle DD, Elias P: 1,25-Dihydroxyvitamin D production and receptor binding in human kératinocytes varies with differentiation. J Biol Chcm 1988:263:5290-5295.
7. Dam TN, Moller B, Hindkjxr J, Kragballe K: The vitamin Dj analogue calcipotriol suppresses the number and antigen-presenting functions of Langcrhans cells in normal human skin. J Invest Dermatol Symp Proc 1996;1:72-77.
8. Yu X-P, Mocharla H, Ilustmycr FG, Manolagas SC: Vitamin D receptor expression in human lymphocytes. J Biol Chcm 1991:266: 7588-7595.
9. Bindcrup L, Carlbcrg C, Kissmcyer A, Latini S, Mathiasen IS, Hansen CM: The need for new vitamin D analogues: mechanisms of action and clinical application: in Norman AW, Bouillon R. Thomasset M (cds): Vitamin D. New York, de Gruytcr. 1994. pp 55-63.
10. Bindcrup L, Latini S, Bindcrup E, Bretting C, Calvcrley M, Hansen K: 20-epi-vitamin Dj analogues: a novel class of potent regulators of cell growth and immune responses. Bio-cheni Pharmacol 1991:42:1569-1575.
11. Evans RM: The steroid and thyroid hormone receptor superfamily. Science 1988;240:889-895.
12. Chem ML, Heinrich G, Ohvania Y, Okuda K, Omdahl JL, Chen TC, Holick MF: Expression of 25-hydroxy vitamin Dj-2 4-hydroxylase mRNA in cultured human keratinocvtes. Proc Soc Exp Biol Med 1994: 207:57-61.
13. Darwish H, DeLuca HF: Identification of a 1.25-dihydroxyvitamin Dj response clement in the 5'-flanking region of the rat calbindin D-9k gene. Proc Nall Acad Sci USA 1992; 89:603-607.
14. Demay MB, Kiernan MS, DeLuca M, Kronenberg HM: Sequences in the human parathyroid hormone gene that bind the 1.25-dihydroxy-vitamin D; receptor and mediate transcriptional repression in response to 1,25-dihydroxyvitamin D,. Proc Natl Acad Sci USA 1992: 89:8097-8101.
15. Demay MB, Gerardi JM, DeLuca H, Kronenberg HM: DNA sequences in the rat osteocalcin gene that bind the 1.25-dihydroxyvitamin Dj receptor and confer responsiveness to 1,25-dihydroxyvitamin Dj. Proc Natl Acad Sci USA 1990; 87:369-373.
16. Kcrner SA, Scott RA, Pike JW: Sequence elements in the human osteocalcin gene confer basal activation and inducible response to hormonal vitamin Dj. Proc Natl Acad Sci USA 1989;86:4455-4459.
17. Ozono K, Liao J, Kcrner SA, Scott RA, Pike JW: The vitamin D-rc-sponsive element in the human osteocalcin gene. J Biol Chem 1990; 265:21881-21888.
18. Quclo I, Kahlcn J, Rasclc A, Jurdic P, Carlberg C: Identification and characterization of a vitamin D3 response element of chicken carbonic anhydrase II. DNA Cell Biol 1994: 13:1181-1187.
19. Umesono K, Murakami KK, Thompson CC. Evans RM: Direct repeats as selective response elements for the thyroid hormone, reti-noic acid, and vitamin Dj receptors. Cell 1991;65:1255-1266.
20. Carlberg C, Bcndik I, Wyss A, Meier E, Sturzenbeckcr LJ, Grippo JF, Hunziker W: Two signalling pathways for vitamin D. Nature 1993; 361:657-660.
21. Carlberg C, Mathiasen IS, Saurat J-H, Bindcrup L: The 1,25-dihy-droxyvitamin Dj (VD) analogues MC 903, EB 1089 and K.H 1060 activate the VD receptor: Homodimers show higher ligand sensitivity than hcterodimcrs with retinoid X receptors. J Steroid Biochem Biol 1994;51:137-142.
22. MacDonald PN, Dowd DR, Nakaji-ma S, Galligan MA, Reeder MC, Haussler CS, Ozato K, Hausslcr MR: Retinoid X receptors stimulate and 9-m-retinoic acid inhibits 1.25-dihydroxyvitamin Deactivated expression of the rat osteocalcin gene. Mol Cell Biol 1993:13:5907-5917.
23. Schrader M, Muller KM, Becker-Andre M, Carlberg C: Response clement selectivity for heterodimeriza-tion of vitamin D receptors with rc-linoic acid and retinoid X receptors. J Mol Endocrinol 1994:12:327-339.
24. Sone T, Ozono K, Pike JW: A 55-kilodalton accessory factor facilitates vitamin D receptor DNA binding. Mol Endocrinol 1991:5:1578-1586.
25. Peleg S, Sastry M, Collins ED, Bishop JE, Norman AW: Distinct conformational changes induced by 20-cpi analogues of 1,25-dihydroxy-vitamin Dj are associated with enhanced activation of the vitamin D receptor. J Biol C'hcm 1995:270: 10551-10558.
26. Iversen L, Fogh K, Ziboh VA, Kris-tensen P, Schmedcs A, Kragballc K: Lcukotrienc B.i formation during human neutrophil keratinocyte interactions: Evidence for transformation of leukotriene Aj by putative keratinocyte leukotriene Aj hydrolase. J Invest Dermatol 1993:100: 293-298.
27. Luckow B, Schütz G: CAT constructions with multiple unique restriction sites for functional analysis of eukaryotic promotors and regulato-rv elements. Nucleic Acids Res I987;15:5490.
28. Sanger F, Nicklen S, Coulson AR: DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 1977;74:5463-5467.
29. Bimboim HC, Dolv J: A rapid alkaline extraction procedure for screening recombinant plasmid DNA. Nucleic Acids Res 1979:7:1513-1523.
30. Radloff R, Bauer W, Vinograd J: A dye-buoyant-density method for the detection and isolation of closed circular duplex DNA: The closed circular DNA in HeLa cells. Biochemistry 1967;57:1514-1521.
31. Levcntis R, Silvius JR: Interactions of mammalian cells with lipid dispersions containing novel metabolizable cationic amphiphiles. Bio-chim Biophvs Acta 1990; 1023:124-132.
32. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protcin-dye binding. Anal Biochem 1976;72: 248-254.
33. Force WR, Tillman JB, Sprung CN, Spindler SR: Homodimer and heterodimer DNA binding and transcriptional responsiveness to triiodothyronine TO and 9-m-rctinoic acid are determined by the number and order of high affinity half-sites in a Tj response element. J Biol Chcrn 1994:269:8863-8871.
34. Sambrook J, Fritsch EF, Maniatis T: in Nolan C (ed): Molecular Cloning: A Laboratory Manual, ed 2. Cold Spring Harbor. Cold Spring Harbor Laboratory Press. 1982.
35. Hollon T, Ycshintura FT: Variation in enzymatic transient gene expression assays. Anal Biochem 1989: 182:411-418.
36. Chen KS, de Luca HF: Cloning of the human la,25-dihydroxy vitamin Dj 24-hydroxvlase gene promoter and identification of two vitamin D-responsive elements. Biochim Bio-physActa 1995;1263:1-9.