Preliminary open-label experience with topiramate in primary generalized seizures

Epilepsia

Volumn 38, Issue SUPPL. 1, 1997, Pages

  Biton, Victor ^a  

^a Arkansas Epilepsy Program   (United States)

Author keywords

Anticonvulsans; Controlled clinical trials; Drug toxicity; Topiramate

Indexed keywords

TOPIRAMATE;

ADULT; AMNESIA; ATAXIA; CLINICAL ARTICLE; CLINICAL TRIAL; CONFERENCE PAPER; DROWSINESS; DRUG EFFICACY; DRUG RESPONSE; DRUG SCREENING; FATIGUE; FEMALE; GRAND MAL EPILEPSY; GRAND MAL SEIZURE; HEADACHE; HUMAN; LONG TERM CARE; MALE; PRIORITY JOURNAL; TREATMENT OUTCOME; VERTIGO;

EID: 0031000085     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1528-1157.1997.tb04518.x     Document Type: Conference Paper

References (14)

1. Maryanoff BE, Margul BL. Topiramate. Drugs Future 1989;14:342-4.
2. Faught E, Wilder BJ, Ramsay RE, et al. Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 200, 400 and 600 mg daily dosages. Neurology 1996;46:1684-90.
3. Privitera M, Fincham R, Penry J, et al. Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 600, 800 and 1000 mg daily dosages: Neurology 1996;46;1678-81.
4. Ben-Menachem E, Henriksen O, Dam M, et al. Double-blind, placebo-controlled trial of topiramate as add-on therapy in patients with refractory partial seizures. Epilepsia 1996;37:539-43.
5. Shank RP, Gardocki JF, Vaught JL, et al. Topiramate: preclinical evaluation of a structurally novel anticonvulsant. Epilepsia 1994;35:450-60.
6. Nakamura J, Tamura S, Kanda T, et al. Inhibition by topiramate of seizures in spontaneously epileptic rats and DBA/2 mice. Eur J Pharmacol 1994;254:83-9.
7. Coulter DA, Sombati S, DeLorenzo RJ. Selective effects of topiramate on sustained repetitive firing and spontaneous bursting in cultured hippocampal neurons. Epilepsia 1993;34(suppl 2): 123.
8. Brown SD, Wolf HH, Swinyard EA, Twyman RE, White HS. The novel anticonvulsant topiramate enhances GABA-mediated chloride flux. Epilepsia 1993;34(suppl 2):122-3.
9. White HS, Brown SD, Skeen DA, Wolf HH, Twyman RE. The anticonvulsant topiramate displays a unique ability to potentiate GABA-evoked currents. Epilepsia 1995;36(suppl 3):39.
10. Severt L, Coulter DA, Sombati S, DeLorenzo RJ. Topiramate selectively blocks kainate currents in cultured hippocampal neurons. Epilepsia 1995;36(suppl 4):38.
11. Macdonald RL, Kelly KM. Mechanisms of action of currently prescribed and newly developed antiepileptic drugs. Epilepsia 1994;35(suppl 4):S41-50.
12. White HS. Clinical significance of animal seizure models and mechanism of action studies of potential antiepileptic drugs. Epilepsia 1997;38(suppl 1 ):S9-17 (this issue)
13. Pledger G, Reife R, Lim P, Karim R. Overview of topiramate efficacy from adjunctive therapy trials. Epilepsia 1995;36(suppl 3): 150.
14. Espe-Lillo J, Ritter FJ, Frost MD, Spiegel RH, Reife R. Topiramate in childhood epilepsy: titration, adverse events, and efficacy in multiple seizure types. Epilepsia 1995;36(suppl 4):56.