Y-26763 protects the canine heart from a stunning injury through opening of the K(ATP) channels

European Journal of Pharmacology

Volumn 323, Issue 2-3, 1997, Pages 197-204

  Fukunari, Atsushi ^a   Miyai, Hisato ^a   Shinagawa, Kenji ^a   Kawahara, Kiminori ^a   Nakajima, Tohru ^a  

^a Research Laboratories   (Japan)

Author keywords

ATP sensitive K+ channel; Ischemia; Myocardium stunned; Reperfusion; Y 26763

Indexed keywords

4 (N ACETYL N HYDROXYAMINO) 6 CYANO 3,4 DIHYDRO 2,2 DIMETHYL 2H 1 BENZOPYRAN 3 OL; GLIBENCLAMIDE; NIFEDIPINE; POTASSIUM CHANNEL; POTASSIUM CHANNEL STIMULATING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOG; FEMALE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEMODYNAMICS; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTIHYPERTENSIVE AGENTS; BENZOPYRANS; CALCIUM CHANNEL BLOCKERS; DOGS; FEMALE; GLYBURIDE; HEMODYNAMIC PROCESSES; MALE; MYOCARDIAL STUNNING; NIFEDIPINE; POTASSIUM CHANNELS;

EID: 0030999918     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)00035-6     Document Type: Article

References (36)

1. Auchampach, J.A., M. Maruyama, I. Cavero and G.J. Gross, 1991, The new K channel opener aprikalim (RP 52891) reduces experimental infarct size in dogs in the absence of hemodynamic changes, J. Pharmacol. Exp. Ther. 259, 961.
2. Auchampach, J.A., M. Maruyama, I. Cavero and G.J. Gross, 1992, Pharmacological evidence for a role of ATP-dependent potassium channels in myocardial stunning, Circulation 86, 311.
3. Baxter, G.F. and D.M. Yellon, 1994, Ischaemic preconditioning of myocardium: a new paradigm for clinical cardioprotection?, Br. J. Clin. Pharmacol. 38, 381.
4. Braunwald, E. and R.A. Kloner, 1982, The stunned myocardium: prolonged, postischemic ventricular dysfunction, Circulation 66, 1146.
5. Cavero, I., 1995, Activation of cardiac ATP-sensitive K channels: a mechanism to reduce and delay ischemia-reperfusion damage, Heart Vessels Suppl. 10, 4.
6. + channels: an obligatory pathway for the cardioprotection afforded by ischemic and pharmacological preconditioning, in: Molecular and Cellular Mechanisms of Cardiovascular Regulation, eds. M. Endoh, M. Morad, H. Scholz and T. Iijima (Springer, Tokyo) p. 69.
7. Cole, W.C., 1993, ATP-sensitive K channels in cardiac ischemia: an endogenous mechanism for protection of the heart, Cardiovasc. Drugs Ther. 7, 527.
8. Cook, N.S., 1988, The pharmacology of potassium channels and their therapeutic potential, Trends Pharmacol. Sci. 9, 21.
9. D'Alomzo, A.J., R.B. Darbenzio, C.S. Parham and G.J. Grover, 1992, Effects of intracoronary cromakalim on postischemic contractile function and action potential duration, Cardiovasc. Res. 26, 1046.
10. Edwards, N.C., A.J. Sinusas, J.D. Bergin, D.D. Warson, M. Ruiz and G.A. Beller, 1992, Influence of subendocardial ischemia on transmural myocardial function, Am. J. Physiol. 262, H568
11. Escande, D. and I. Cavero, 1992, K channel opener and 'natural' cardioprotection, Trends Pharmacol. Sci. 13, 269.
12. + channels, J. Biol. Chem. 263, 7933.
13. Gross, G.J. and L.A. Auchampach, 1992, Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs, Circ. Res. 70, 223.
14. Gross, G.J., G.M. Pieper and D.C. Warltier, 1987a, Comparative effects of nicorandil, nitroglycerin, nicotinic acid, and SG-86 on the metabolic status and functional recovery of the ischaemic-reperfused myocardium, J. Cardiovasc. Pharmacol. 10 (Suppl. 8), S76.
15. Gross, G.J., D.C. Warltier and H.F. Hardman, 1987b, Comparative effects of nicorandil, a nicotinamide nitrate derivative, and nifedipine on myocardial reperfusion injury in dogs, J. Cardiovasc. Pharmacol. 10, 535.
16. Grover, G.J., P.G. Sleph and S. Dzwonczyk, 1990, Pharmacologic profile of cromakalim in the treatment of myocardial ischemia in isolated rat hearts and anesthetized dogs, J. Cardiovasc. Pharmacol. 16, 853.
17. Hartley, C.J., L.A. Latson, L.H. Michael, C.L. Seidel, R.M. Lewis and M.L. Entman, 1983, Doppler measurement of myocardial thickening with a single epicardial transducer, Am. J. Physiol. 245, H1066.
18. Kantor, P.F., W.A. Coetzee, E.E. Carmeliet, S.C. Dennis and L.H. Opie, 1990, Reduction of ischemic K loss and arrhythmias in rat hearts: effect of glibenclamide, a sulfonylurea, Circ. Res. 66, 478.
19. Kawahara, K. and T. Nakajima, 1994, Effect of a novel K channel opener Y-26763, an active metabolite of Y-27152, on contraction and monophasic action potential during normoxia in blood-perfused canine papillary muscle, Can. J. Physiol. Pharmacol. 72 (Suppl. 1), 92.
20. Kloner, B.A. and D.M. Yellon, 1994, Does ischemic preconditioning occur in patients?, J. Am. Coll. Cardiol. 24, 1133.
21. Lawson, C.S., 1994, Does ischaemic preconditioning occur in the human heart?, Cardiovasc. Res. 28, 1461.
22. + channels involves high-energy phosphate preservation, Am. J. Physiol. 265, H1809.
23. + channel opener with less incidence of tachycardia, Cardiovasc. Drug Rev. 9, 372.
24. + channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state, J. Pharmacol. Exp. Ther. 261, 730.
25. + channels in cardiac muscle, Nature 305, 147.
26. Ohta, H., Y. Jinno, K. Harada, N. Ogawa and H. Fukushima, 1991, Cardioprotective effects of KRN2391 and nicorandil on ischemic dysfunction in perfused rat heart, Eur. J. Pharmacol. 204, 171.
27. Opie, L.H., 1993, Modulation of ischemia by regulation of the ATP-sensitive potassium channel, Cardiovasc. Drugs Ther. 7, 507.
28. Pitsillides, K.F. and J.C. Longhurst, 1993, An ultrasonic system for measurement of absolute myocardial thickness using a single transducer, Am. J. Physiol. 268, H1358.
29. ATP channels, Eur. J. Pharmacol. 317, 293.
30. Sargent, C.A., M.A. Smith, S. Dzwonczyk, P.G. Sleph and G.J. Grover, 1991, Effect of potassium channel blockade on the anti-ischemic actions of mechanistically diverse agents, J. Pharmacol. Exp. Ther. 259, 97.
31. 2+ channels, J. Am. Coll. Cardiol. 26, 1365.
32. + channel blocker, Circulation 90, 700.
33. Wilde, A.A.M., D. Escande, C.A. Shumacher, D. Thuringer and M. Mestre, 1990, Potassium accumulation in the globally ischemic mammalian heart: a role for the ATP-sensitive potassium channel, Circ. Res. 67, 835.
34. Yao, Z. and G.J. Gross, 1994a, Activation of ATP-sensitive potassium channels lowers threshold for ischemic preconditioning in dogs, Am. J. Physiol. 267, H1888.
35. Yao, Z. and G.J. Gross, 1994b, Effects of the KATP channel opener bimakalim on coronary blood flow, monophasic action potential duration, and infarct size in dogs, Circulation 89, 1769.
36. Yellon, D.M., A.M. Alkhulaifi and W.B. Pugsley, 1993, Preconditioning the human myocardium, Lancet 342, 276.