Y-26763 protects the working rat myocardium from ischemia/reperfusion injury through opening of K(ATP) channels

European Journal of Pharmacology

Volumn 317, Issue 2-3, 1996, Pages 293-299

  Rahman, Fazlur ^a   Kato, Akira ^a   Kawahara, Kiminori ^a   Nakajima, Tohru ^a  

^a Research Laboratories   (Japan)

Author keywords

ATP sensitive; Cardioprotection; Glibenclamide; K+ channel; K+ channel opener; Y 26763

Indexed keywords

4 (N ACETYL N HYDROXYAMINO) 6 CYANO 3,4 DIHYDRO 2,2 DIMETHYL 2H 1 BENZOPYRAN 3 OL; GLIBENCLAMIDE; POTASSIUM CHANNEL; POTASSIUM CHANNEL STIMULATING AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ENERGY; CONTROLLED STUDY; DRUG EFFECT; HEART MUSCLE ISCHEMIA; HEART OUTPUT; HEART PROTECTION; HIGH ENERGY PHOSPHATE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTIHYPERTENSIVE AGENTS; BENZOPYRANS; ENERGY METABOLISM; GLYBURIDE; HYPOGLYCEMIC AGENTS; MALE; MICROSCOPY, ELECTRON; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; PHOSPHATES; POTASSIUM CHANNELS; RATS; RATS, WISTAR;

EID: 0030593911     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(96)00741-8     Document Type: Article

References (27)

1. Ashcroft, F.M., D.E. Harrison and S.J.H. Ashcroft, 1985, Glucose induces closure of single potassium channels in isolated rat pancreatic β-cells, Nature 312, 446.
2. 1, J. Pharmacol. Exp. Ther. 259, 961.
3. Cavero, I., S. Mondont and M. Mestre, 1989, Vasorelaxant effects of cromakalim in rats are mediated by glibenclamide-sensitive potassium channels, J. Pharmacol. Exp. Ther. 248, 1261.
4. + channels: an obligatory pathway for the cardioprotection afforded by ischemic and pharmacological preconditioning, in: Molecular and Cellular Mechanisms of Cardiovascular Regulation, eds. M. Endoh , M. Morad, H. Scholz and T. Iijima (Springer, Tokyo) p. 69.
5. Cook, N.S., 1988, The pharmacology of potassium channels and their therapeutic potential, Trends Pharmacol. Sci. 9, 21.
6. + channels in guinea-pig cardiac myocytes, Pflügers Arch. 414, 669.
7. + channel openers and `natural' cardioprotection, Trends Pharmacol. Sci. 13, 269.
8. + channels, J. Biol. Chem. 263, 7933.
9. Grover, G.J., J.R. McCullough, D.E. Henry, M.L. Conder and P.G. Sleph, 1989, Anti-ischemic effects of the potassium channel activators pinacidil and cromakalim and the reversal of these effects with the potassium channel blocker glyburide, J. Pharmacol. Exp. Ther. 251, 98.
10. Grover, G.J., S. Dzwonczyk, C.S. Parham and P.G. Sleph, 1990, The protective effects of cromakalim and pinacidil on reperfusion function and infarct size in isolated perfused rat hearts and anesthetized dogs, Cardiovasc. Drugs Ther. 4, 465.
11. Grover, G.J., J. Newburger, P.G. Sleph, S. Dzwonczyk, S.C. Taylor, S.Z. Ahmed and K.S. Atwal, 1991, Cardioprotective effects of potassium channel opener cromakalim: stereoselectivity and effects on myocardial adenine nucleotides, J. Pharmacol. Exp. Ther. 257, 156.
12. Hearse, D.J., 1977, Reperfusion of the ischemic myocardium, J. Mol. Cell Cardiol. 9, 605.
13. Hearse, D.J., P.B. Garlick and S.M. Humphrey, 1977, Ischemic contracture of the myocardium: mechanisms and prevention, Am. J. Cardiol. 39, 986.
14. + channels involves high-energy phosphate preservation, Am. J. Physiol. Soc. H1809.
15. Monticello, T.M., C.A. Sargent, J.R. McGill, D.S. Barton and G.J. Grover, 1996, Amelioration of ischemia/reperfusion injury in isolated rat hearts by the ATP-sensitive potassium channel opener BMS-180448, Cardiovasc. Res. 31, 93.
16. + channel opener with less incidence of tachycardia, Cardiovasc. Drug Rev. 9, 372.
17. + channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state, J. Pharmacol. Exp. Ther. 261, 730.
18. + channels in cardiac muscle, Nature 305, 147.
19. Ohta, H., Y. Jinno, K. Harada, N. Ogawa and H. Fukushima, 1991, Cardioprotective effects of KRN2391 and nicorandil on ischemic dysfunction in perfused rat heart, Eur. J. Pharmacol. 204, 171.
20. + channel openers on ischemic dysfunction and metabolic disturbance in isolated perfused rat heart, Eur. J. Pharmacol. 231, 323.
21. Opie, L.H., 1989, Reperfusion injury and its pharmacologic modification, Circulation 80, 1049.
22. + channels, Trends Pharmacol. Sci. 10, 431.
23. Sargent, C.A., M.A. Smith, S. Dzwonczyk, P.G. Sleph and G.J. Grover, 1991, Effect of potassium channel blockade on the anti-ischemic actions of mechanistically diverse agents, J. Pharmacol. Exp. Ther. 259, 97.
24. Sellevold, O.F.M., P. Jynger and K. Aarstad, 1986, High performance liquid chromatography: a rapid isocratic method for determination of creatine compound and adenine nucleotides in myocardial tissue, J. Mol. Cell Cardiol. 18, 517.
25. Spruce, A.E., N.B. Standen and P.R. Stanfield, 1985, Voltage-dependent ATP-sensitive potassium channels of skeletal muscle membrane, Nature 316, 736.
26. + channels in arterial smooth muscle, Science 245, 177.
27. ATP channel opener bimakalim on coronary blood flow, monophasic action potential duration, and infarct size in dogs, Circulation 89, 1769.