Preliminary observations on topiramate in pediatric epilepsies

Epilepsia

Volumn 38, Issue SUPPL. 1, 1997, Pages

  Glauser, Tracy A ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Anticonvulsants; Drug interactions; Drug toxicity; Lennox Gastaut syndrome; Partial seizures; Pharmacokinetics; Topiramate

Indexed keywords

ANTICONVULSIVE AGENT; TOPIRAMATE;

ABSENCE; BENIGN CHILDHOOD EPILEPSY; CHILD; CLINICAL TRIAL; CONFERENCE PAPER; DRUG EFFICACY; DRUG RESEARCH; DRUG SCREENING; FOCAL EPILEPSY; GRAND MAL EPILEPSY; HUMAN; LENNOX GASTAUT SYNDROME; PRIORITY JOURNAL; TONIC SEIZURE;

EID: 0030998625     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1528-1157.1997.tb04517.x     Document Type: Conference Paper

References (22)

1. Hauser WA. Seizure disorders: the changes with age. Epilepsia 1992;33(suppl 4):S6-14.
2. Graves NM, Leppik IE. Advances in pharmacotherapy: recent developments in the treatment of epilepsy. J Clin Pharmacol Ther 1993;18:227-42.
3. Coulter DA, Sombati S, DeLorenzo RJ. Selective effects of to- piramate on sustained repetitive firing and spontaneous bursting in cultured hippocampal neurons. Epilepsia 1993;34(suppl 2): 123.
4. Macdonald RL. Antiepileptic drug actions. Epilepsia 1989;30(suppl 1):S 19-28.
5. White HS, Brown SD, Skeen GA, Wolf HH, Twyman RE. The anticonvulsant topiramate displays a unique ability to potentiate GABA-evoked chloride currents. Epilepsia 1995;36(suppl 3):39.
6. Severt L, Coulter DA, Sombati S, DeLorenzo RJ. Topiramate selectively blocks kainate currents in cultured hippocampal neurons. Epilepsia 1995;36(suppl 4):38.
7. Rosenfeld WE, Doose DR, Walker SA, Schaefer P, Reife RA. The steady-state pharmacokinetics of topiramate as adjunctive therapy in pediatric subjects with epilepsy. Epilepsia 1995;36(suppl 3):158.
8. Bourgeois BFD. Antiepileptic drugs in pediatric practice. Epilepsia 1995;36(suppl 2):S34-45.
9. Henriksen O, Johannessen SI. Clinical and pharmacokinetic observations on sodium valproate - a 5 year follow-up study in 100 children with epilepsy. Acta Neurol Scand 1982;65:504-23.
10. Group for the Evaluation of Cinromide in the Lennox-Gastaut Syndrome. Double-blind, placebo-controlled evaluation of cinromide in patients with the Lennox-Gastaut syndromes. Epilepsia 1989;30:422-9.
11. Pledger GW, Schmidt D. Evaluation of antiepileptic drug efficacy. A review of clinical trial design. Drugs 1994;48:498-509.
12. The Felbamate Study Group in Lennox-Gastaut Syndrome. Efficacy of felbamate in childhood epileptic encephalopathy. N Engl J Med 1993;328:29-33.
13. Pennell PB, Ogaily MS, Macdonald RL. Aplastic anemia in a patient receiving felbamate for partial seizures. Neurology 1995;45:456-60.
14. Anonymous. Liver failure linked to felbamate use. Am J Hosp Pharm 1994;51:2282.
15. Faught E, Wilder BJ, Ramsay BE, et al. Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 200, 400 and 600 mg daily dosages. Neurology 1996;46:1684-90.
16. Privitera M, Fincham R, Penry J, et al. Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 600, 800 and 1000 mg daily dosages. Neurology 1996;46:1678-83.
17. Livingston JH, Beaumont D, Arzimanoglou A, Aicardi J. Vigabatrin in the treatment of epilepsy in children. Br J Clin Pharmacol 1989;27:109S-12S.
18. Lortie A, Chiron C, Mumford J, Dulac O. The potential for increasing seizure frequency, relapse, and appearance of new seizure types with vigabatrin. Neurology 1993;43(suppl 5):S24-7.
19. Oller LFV, Russi A, Oller Daurella L. Lamotrigine in the Lennox-Gastaut syndrome. Epilepsia 1991;32(suppl 1):58.
20. Timmings PL, Richens A. Lamotrigine as add-on drug in the management of Lennox-Gastaut syndrome. Eur Neurol 1992;32:305-7.
21. Richens A, Yuen AWC. Overview of the clinical efficacy of lamotrigine. Epilepsia 1989;32(suppl 2):S13-6.
22. Leiderman D, Garofalo E, Lamoreaux L. Gabapentin patients with absence seizures: two double-blind, placebo-controlled studies. Epilepsia 1993;34(suppl 6):45.