Mutations in the Drosophila pushover gene confer increased neuronal excitability and spontaneous synaptic vesicle fusion

Genetics

Volumn 142, Issue 4, 1996, Pages 1215-1223

  Richards, Stephen ^a   Hillman, Timothy ^a   Stern, Michael ^a  

^a RICE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROTRANSMITTER;

ARTICLE; DROSOPHILA; GENE MUTATION; GENETIC ANALYSIS; GENETIC COMPLEMENTATION; MEMBRANE FUSION; NERVE CELL EXCITABILITY; NEUROMUSCULAR SYNAPSE; NONHUMAN; PRIORITY JOURNAL; SYNAPSE VESICLE; SYNAPTIC TRANSMISSION;

NON-PROGRAMMATIC;

ANIMALS; BEHAVIOR, ANIMAL; CHROMOSOME MAPPING; DROSOPHILA; ELECTROPHYSIOLOGY; FERTILITY; GENES, INSECT; MALE; MEMBRANE FUSION; MUTATION; NEUROMUSCULAR JUNCTION; POTASSIUM CHANNEL BLOCKERS; QUINIDINE; SYNAPTIC TRANSMISSION; SYNAPTIC VESICLES;

EID: 0029867583     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. BARCHI, R. L., 1995 Molecular pathology of skeletal muscle sodium channel. Annu. Rev. Physiol. 57: 355-385.
2. BRAHA, O., N. DALE, B. HOCHNER, M. KLEIN, T. W. ABRAMS et al., 1990 Second messengers involved in the two processes of presynaptic facilitation that contribute to sensitization and dishabituation in Aplysia sensory neurons. Proc. Natl. Acad. Sci USA 87: 2040-2044.
3. CHAVEZ-NORIEGA, L. E., and C. F. STEVENS, 1994 Increased transmitter release at excitatory synapse produced by direct activation of adenylate cyclase in rat hippocampal slices. J. Neuroscience 14: 310-317.
4. DEL CASTILLO, J., and B. KATZ, 1954 Changes in end-plate activity produced by pre-synaptic polarization. J. Physiol. 124: 586-604.
5. DIANTONIO, A., and T. L. SCHWARZ, 1994 The effect on synaptic physiology of synaptotagmin mutations in Drosophila. Neuron 12: 909-920.
6. GANETZKY, B., and C.-F. WU, 1982a Drosophila mutants with opposing effects on nerve excitability: genetic and spatial interactions in repetitive firing. J. Neurophys. 47: 501-514.
7. GANETZKY, B., and C.-F. WU, 1982b Indirect suppression involving behavioral mutants with altered nerve excitability in Drosophila. Genetics 100: 597-614.
8. GANETZKY, B., and C.-F. WU, 1983 Neurogenetic analysis of potassium currents in Drosophila: synergistic effects on neuromuscular transmission in double mutants. J. Neurogenet. 1: 17-28.
9. GEPPERT, M., V. Y. BOLSHAKOV, S. A. SIEGELBAUM, K. TAKEI, P. DECAMILLI et al., 1994 The role of Rab3A in neurotransmitter release. Nature 369: 493-497.
10. GEPPERT, M., Y. GODA, R. E. HAMMER, C. LI, T. W. ROSAHL et al., 1994 Synaptotaginin I: a major Ca2+ sensor for transmitter release at a central synapse. Cell 79: 717-727.
11. GHIRARDI, M., O. BRAHA, B. HOCHNER, P. G. MONTAROLO, E. R. KANDEL et al., 1992 Roles of PKA and PKC in facilitation of evoked and spontaneous transmitter release at depressed and nondepressed synapses in Aplysia sensory neurons. Neuron 9: 479-489.
12. GHO, M., K. MCDONALD, B. GANETZKY and W. M. SAXTON, 1992 Effects of kinesin mutations on neuronal functions. Science 258: 313-316.
13. GREENGARD, P., F. VALTORTA, A. J. CZERNIK and F. BENFANATI, 1993 Synaptic vesicle phosphoproteins and regulation of synaptic function. Science 259: 780-785.
14. HALL, D. H., and E. M. HEDGECOCK, 1991 Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans. Cell 65: 837-847.
15. JAN, L. Y., and Y. N. JAN, 1976 Properties of the larval neuromuscular junction in Drosophila melanogaster. J. Physiol. 262: 189-214
16. JAN, Y. N., and L. Y. JAN, 1979 Genetic dissection of synaptic transmission in Drosophila melanogaster, pp. 161-168 in Insect Neurobiology and Pesticide Actions, edited by F. E. RICKETT. Society of Chemical Industry, London.
17. JAN, Y. N., L. Y. JAN and M. J. DENNIS, 1977 Two mutations of synaptic transmission in Drosophila. Proc. R. Soc. Lond. B. 198: 87-108.
18. KAPLAN, W. D., and W. E. TROUT III, 1969 The behavior of four neurological mutants of Drosophila. Genetics 61: 399-409.
19. LINDSLEY, D. L., and G. G. ZIMM, 1992 The Genome of Drosophila melanogaster. Academic Press, New York.
20. LITTLETON, J. T., and H. J. BELLEN, 1995 Synaptotagmin controls and modulates synaptic-vesicle fusion in a Ca2+-dependent manner. Trends Neurosci. 18: 177-183.
21. 2+-activated neurotransmitter release. Cell 74: 1125-1134.
22. LOUGHNEY, K., R. KREBER and B. GANETZKY, 1989 Cloning and sequence analysis of the para locus, a sodium channel gene in Drosophila. Cell 58: 1143-1154.
23. MALLART, A., D. ANGAUTPETIT, C. BOURRETPOULAIN and A. FERRUS, 1991 Nerve terminal excitability and neuromuscular transmission in T(X;Y)V7 and Shaker mutants of Drosophila melanogaster. J. Neurogenet. 7: 75-84.
24. NONET, M. L., K. GRUNDAHL, B. J. MEYER and J. B. RAND, 1993 Synaptic function is impaired but not eliminated in C. elegans mutants lacking Synaptotagmin. Cell 73: 1291-1305.
25. RIESGO-ESCOVAR, J., C. WOODWARD, P. GAINES and J. CARLSON, 1992 Development and organization of the Drosophila olfactory system: an analysis using enhancer traps. J. Neurobiology 23: 947-964.
26. ROSAHL, T. W., D. SPILLANE, M. MISSLER, J. HERZ, D. K. SELIG et al., 1995 Essential functions of synapsins I and II in synaptic vesicle regulation. Nature 375: 488-493.
27. SCHUTZE, K. L., J. T. LITTLETON, A. SALZBERG, N. HALACHMI, M. STERN et al., 1994 rop, a Drosophila homolog of yeast Sec1 and vertebrate n-Sec1/Munc-18 proteins, is a negative regulator of neurotransmitter release in vivo. Neuron 13: 1099-1108.
28. SINGH, S., and C.-F. WU, 1989 Complete separation of four potassium currents in Drosophila. Neuron 2: 1325-1329.
29. STERN, M., and B. GANETZKY, 1989 Altered synaptic transmission in Drosophila Hyperkinetic mutants. J. Neurogen. 5: 215-229.
30. STERN, M., and B. GANETZKY, 1992 Identification and characterization of inebriated, a gene affecting neuronal excitability in Drosophila. J. Neurogen. 8: 157-172.
31. STERN, M., R. KREBER and B. GANETZKI, 1989 Dosage effects of a Drosophila sodium channel gene on behavior and axonal excitability. Genetics 124: 133-143.
32. STERN, M., N. BLAKE, N. ZONDLO and K. WALTERS, 1995 Increased neuronal excitability conferred by a mutation in the Drosophila bemused gene. J. Neurogenet. 10: 103-118.
33. SUDHOF, T. C., 1995 The synaptic vesicle cycle: a cascade of protein-protein interactions. Nature 375: 645-653.
34. SUZUKI, D T., T. GRIGLIATTI and R. WILLIAMSON, 1971 Temperature-sensitive mutants in Drosophila melanogaster. VII. A mutation (parats1) causing reversible adult paralysis. Proc. Natl. Acad. Sci. USA 68: 890-893.
35. TANIMOTO, S., Y. KUDO, T. NAKAZAWA and M. MORISAWA, 1994 Implication that potassium flux and increase in intracellular calcium are necessary for the initiation of sperm motility in salmonid fishes. Mol. Reprod. Dev. 39: 409-414.
36. TEMPEL, B. L., D. M. PAPAZIAN, T. L. SCHWARZ, Y. N. JAN and L. Y. JAN, 1987 Sequence of a probable potassium channel component encoded at the Shaker locus of Drosophila. Science 237: 770-775.
37. VALE, R. D., T. S. REESE and M. P. SHEETZ, 1985 Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility. Cell 42: 39-50.
38. WALCZAK, C. E., and D. L. NELSON, 1994 Regulation of dynein-driven motility in cilia and flagella. Cell Motil. Cytoskel. 27: 101-107.
39. WANG, Q., J. X. SHEN, Z. Z. LI, K. TIMOTHY, G. M. VINCENT et al., 1995 Cardiac sodium channel mutations in patients with long QT syndrome, an inherited cardiac arrhythmia. Hum. Mol. Genet. 4: 1603-1607.
40. WARMKE, J., R. DRYSDALE and B. GANETZKY, 1991 A distinct potassium channel polypeptide encoded by the Drosophila-eag locus. Science 252: 1560-1562
41. WU, C.-F., and B. GANETZKY, 1980 Genetic alteration of nerve membrane excitability in temperature-sensitive paralytic mutants of Drosophila melanogaster. Nature 286: 814-816.
42. + channel-specific drugs and mutations. J. Exp. Biol. 147: 21-41.
43. ZHONG, Y., and C.-F. WU, 1991 Altered synaptic plasticity in Drosophila memory mutants with a defective cyclic AMP cascade. Science 251: 198-201.