Outcome of acute leukemia relapsing after bone marrow transplantation: Utility of second transplants and adoptive immunotherapy

Bone Marrow Transplantation

Volumn 19, Issue 7, 1997, Pages 709-719

  Mehta, J ^a,b   Powles, R ^a   Treleaven, J ^a   Horton, C ^a   Meller, S ^a   Pinkerton, C R ^a   Singhail, S ^a  

^a ROYAL MARSDEN HOSPITAL   (United Kingdom)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Acute leukemia; Allogeneic bone marrow transplantation; Autologous bone marrow transplantation; Immunotherapy; Relapse; Repeat transplantation; Salvage therapy

Indexed keywords

BUSULFAN; CYCLOPHOSPHAMIDE; CYCLOSPORIN; CYTARABINE; CYTOKINE; MELPHALAN; METHOTREXATE; PREDNISOLONE; VINCA ALKALOID;

ACUTE LEUKEMIA; ADOLESCENT; ADOPTIVE IMMUNOTHERAPY; ADULT; ALLOGENIC BONE MARROW TRANSPLANTATION; ARTICLE; AUTOLOGOUS BONE MARROW TRANSPLANTATION; CHILD; DEATH; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; PALLIATIVE THERAPY; PRIORITY JOURNAL; RELAPSE; SALVAGE THERAPY;

EID: 0030996274     PISSN: 02683369     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bmt.1700720     Document Type: Article

References (40)

1. Frassoni F, Barrett AJ, Granena A et al. Relapse after allogeneic bone marrow transplantation for acute leukaemia: a survey by the EBMT of 117 cases. Br J Haematol 1988; 70: 317-320.
2. Mortimer J, Blinder MA, Schulman S et al. Relapse of acute leukemia after marrow transplantation: natural history and results of subsequent therapy. J Clin Oncol 1989; 7: 50-57, erratum J Clin Oncol 1989; 7: 545.
3. Sica S, Di Mario A, Pagano L et al. Aggressive chemotherapy for acute leukemia relapsed after bone marrow transplantation: a second chance? Acta Haematol 1992; 87: 173-175.
4. Wright SE, Thomas ED, Buckner CD et al. Experience with second marrow transplants. Exp Hematol 1976; 4: 221-226.
5. Atkinson K, Biggs J, Concannon A et al. Second marrow transplants for recurrence of haematological malignancy. Bone Marrow Transplant 1986; 1: 159-166.
6. Blume KG, Forman SJ. High dose busulfan/etoposide as a preparatory regimen for second bone marrow transplants in hematologic malignancies. Blut 1987; 55: 49-53.
7. Sanders JE, Buckner CD, Clift RA et al. Second marrow transplants in patients with leukemia who relapse after allogeneic marrow transplantation. Bone Marrow Transplant 1988; 3: 11-19.
8. Barrett AJ, Locatelli F, Treleaven JG et al. Second transplants for leukaemic relapse after bone marrow transplantation: high early mortality but favourable effect of chronic GVHD on continued remission. A report by the EBMT Leukaemia Working Party. Br J Haematol 1991; 79: 567-574.
9. Wagner JE, Vogelsang GB, Zehnbauer BA et al. Relapse of leukemia after bone marrow transplantation: effect of second myeloablative therapy. Bone Marrow Transplant 1992; 9: 205-209.
10. Mrsic M, Horowitz MM, Atkinson K et al. Second HLA-identical sibling transplants for leukemia recurrence. Bone Marrow Transplant 1992; 9: 269-275.
11. Spinolo JA, Yau JC, Dicke KA et al. Second bone marrow transplants for relapsed leukemia. Cancer 1992; 69: 405-409.
12. Radich JP, Sanders JE, Buckner CD et al. Second allogeneic marrow transplantation for patients with recurrent leukemia after initial transplant with total-body irradiation-containing regimens. J clin Oncol 1993; 11: 304-313.
13. Shing MM, Vowels M. Role of second bone marrow transplants. Bone Marrow Transplant 1993; 12: 21-25.
14. Chiang KY, Weisdorf DJ, Davies SM et al. Outcome of second bone marrow transplantation following a uniform conditioning regimen as therapy for malignant relapse. Bone Marrow Transplant 1996; 17: 39-42.
15. Giralt S, Escudier S, Kantarjian H et al. Preliminary results of treatment with filgrastim for relapse of leukemia and myelodysplasia after allogeneic bone marrow transplantation. New Engl J Med 1993; 329: 757-761.
16. Komori T, Sugiyama H, Ogawa H et al. Treatment of a patient in a relapse after bone marrow transplantation for acute lymphoblastic leukemia with the systemic administration of allogeneic lymphokine-activated killer cells and recombinant interleukin-2. Eur J Haematol 1989; 43: 184-185.
17. Szer J, Grigg AP, Phillips GL et al. Donor leucocyte infusions after chemotherapy for patients relapsing with acute leukaemia following allogeneic BMT. Bone Marrow Transplant 1993; 11: 109-111.
18. Mehta J, Powles R, Singhal S et al. Cytokine-mediated immunotherapy with or without donor leukocytes for poor-risk acute myeloid leukemia relapsing after allogeneic bone marrow transplantation. Bone Marrow Transplant 1995; 16: 133-137.
19. Kolb HJ, Schattenberg A, Goldman JM et al. Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. Blood 1995; 86: 2041-2050.
20. Slavin S, Naparstek E, Nagler A et al. Allogeneic cell therapy for relapsed leukemia after bone marrow transplantation with donor peripheral blood lymphocytes. Exp Hematol 1995; 23: 1553-1562.
21. Mehta J. The first clinical use of donor leukocyte infusions for the treatment of leukemia relapsing after allogeneic bone marrow transplantation. Blood 1996; 87: 4010.
22. Talbot DC, Powles RL, Sloane JP et al. Cyclosporine-induced graft-versus-host disease following autologous bone marrow transplantation in acute myeloid leukaemia. Bone Marrow Transplant 1990; 6: 17-20.
23. Takamatsu Y, Teshima T, Akashi K et al. Successful second autologous blood stem cell transplantation after G-CSF-combined conditioning for the treatment of high-risk acute myelogenous leukemia. Bone Marrow Transplant 1994; 13: 325-327.
24. Schwella N, Schwerdtfeger R, Konig V et al. Allogeneic bone marrow transplantation for recurrence of leukemia after autologous bone marrow transplantation. Transplantation 1994; 57: 1263-1265.
25. Powles R, Milan S, Horton C et al. A prospective haematooncology patient database: structure and description. Bone Marrow Transplant 1996; 17 (Suppl. 1): S140.
26. Powles R, Milan S, Horton C et al. A prospective haematooncology patient database for use in routine care and clinical research. Bone Marrow Transplant 1996; 17 (Suppl. 1): S55.
27. Mehta J, Powles R, Singhal S et al. Outcome of autologous rescue after failed engraftment of allogeneic marrow. Bone Marrow Transplant 1996; 17: 213-217.
28. Gore M, Powles R, Lakhani A et al. Treatment of relapsed and refractory acute leukaemia with high-dose cytosine arabinoside and etoposide. Cancer Chemother Pharmacol 1989; 23: 373-376.
29. Mehta J, Powles R, Singhal S et al. Idarubicin, high-dose cytarabine and etoposide for induction of remission in acute leukemia. Semin Hematol 1996; 33 (Suppl. 3): (in press).
30. Mehta J, Powles R, Singhal S et al. Sequential high-dose therapy of adult acute lymphoblastic leukemia: role of maintenance chemotherapy after peripheral blood stem cell transplantation in first remission. In: Dicke KA, Keating A (eds). Autologous Marrow and Blood Transplantation: Proc Seventh Int Symp, Arlington, Texas. The Cancer Treatment Research and Educational Institute: Arlington, 1995, pp 135-144.
31. Mehta J, Powles R, Singhal S et al. Consolidation therapy of adult acute lymphoblastic leukemia: role of sequential auto and allografting. Blood 1995; 86 (Suppl. 1): 384a.
32. Mehta J, Powles RL, Mitchell P et al. Graft failure after bone marrow transplantation from unrelated donors using busulphan and cyclophosphamide for conditioning. Bone Marrow Transplant 1994; 13: 583-587.
33. Mehta J, Powles R, Horton C et al. Bone marrow transplantation for primary refractory acute leukaemia. Bone Marrow Transplant 1994; 14: 415-418.
34. Singhal S, Mehta J, Powles R el al. Three weeks of ganciclovir for cytomegaloviraemia after allogeneic bone marrow transplantation. Bone Marrow Transplant 1995; 15: 777-781.
35. Mehta J, Powles R, Horton C et al. The relationship between donor-recipient blood group incompatibility and serum bilirubin after allogeneic bone marrow transplantation from HLA-identical siblings. Bone Marrow Transplant 1995; 15: 853-858.
36. Mehta J, Powles R, Singhal S et al. Autologous bone marrow transplantation for acute myeloid leukemia in first remission: identification of modifiable prognostic factors. Bone Marrow Transplant 1995; 16: 499-506.
37. Dunlop L, Powles R, Singhal S et al. Bone marrow transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia. Bone Marrow Transplant 1996; 17: 365-369.
38. Singhal S, Powles R, Treleaven J et al. Central nervous system relapse after bone marrow transplantation for acute leukemia in first remission. Bone Marrow Transplant 1996; 17: 637-641.
39. Mehta J. Graft-versus-leukemia reactions in clinical bone marrow transplantation. Leuk Lymphoma 1993; 10: 427-132.
40. Powles R, Mehta J, Singhal S et al. Autologous bone marrow or peripheral blood stem cell transplantation followed by maintenance chemotherapy for adult acute lymphoblastic leukemia in first remission: 50 cases from a single center. Bone Marrow Transplant 1995; 16: 241-247.