메뉴 건너뛰기




Volumn 3, Issue 2, 1996, Pages 171-178

Effect of DSG on xenogeneic immune reactivity with special emphasis on human anti-pig cellular reactions in vitro

Author keywords

Anti pig; CsA; DSG; FK506; Human; Immune; Reactions; Xenotransplantation

Indexed keywords


EID: 0041491741     PISSN: 0908665X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-3089.1996.tb00135.x     Document Type: Article
Times cited : (8)

References (48)
  • 3
    • 85033836051 scopus 로고    scopus 로고
    • Direct activation of human responder T cell by porcine stimulator cells leads to T cell proliferation and CTL development
    • submitted
    • SATAKE M, KAWAGISHI N, MÖLLER E. Direct activation of human responder T cell by porcine stimulator cells leads to T cell proliferation and CTL development. Xenotransplantation, submitted.
    • Xenotransplantation
    • Satake, M.1    Kawagishi, N.2    Möller, E.3
  • 4
    • 0025941970 scopus 로고
    • Evidence for direct and indirect pathways in the generation of the alloimmune response against pancreatic islets
    • STOCK PG, ASCHER NL, CHEN S, FIELD J, BACH FH, SUTHERLAND DER. Evidence for direct and indirect pathways in the generation of the alloimmune response against pancreatic islets. Transplantation 1991:52:704.
    • (1991) Transplantation , vol.52 , pp. 704
    • Stock, P.G.1    Ascher, N.L.2    Chen, S.3    Field, J.4    Bach, F.H.5    Sutherland, D.E.R.6
  • 5
    • 0028155699 scopus 로고
    • Kinetics and character of xenoantibody formation in diabetic patients transplanted with fetal porcine islet clusters
    • SATA KE M, KUMAGAI-BRAESCH M, KAWAGISHI N, TIBELL A, GROTH C-G, MÖLLER E. Kinetics and character of xenoantibody formation in diabetic patients transplanted with fetal porcine islet clusters. Xeno 1994:1:24.
    • (1994) Xeno , vol.1 , pp. 24
    • Sata, K.E.M.1    Kumagai-Braesch, M.2    Kawagishi, N.3    Tibell, A.4    Groth, C.-G.5    Möller, E.6
  • 10
    • 0025007926 scopus 로고
    • Therapeutic effect of 15-deoxyspergualin on the progression of lupus nephritis in MRL mice. I. Immunopathological analyses
    • ITO S, UENO M, ARAKAWA M, SAITO T, AOYAGI T, FUJIWARA M. Therapeutic effect of 15-deoxyspergualin on the progression of lupus nephritis in MRL mice. I. Immunopathological analyses. Clin Exp Immunol 1990:81:446.
    • (1990) Clin Exp Immunol , vol.81 , pp. 446
    • Ito, S.1    Ueno, M.2    Arakawa, M.3    Saito, T.4    Aoyagi, T.5    Fujiwara, M.6
  • 11
    • 0026802043 scopus 로고
    • The suppressive effect of deoxyspergualin on the differentiation of human B lymphocytes maturing into immunoglobulin-producing cells
    • MORIKAWA K, OSEKO F, MORIKAWA S. The suppressive effect of deoxyspergualin on the differentiation of human B lymphocytes maturing into immunoglobulin-producing cells. Transplantation 1992:54:526.
    • (1992) Transplantation , vol.54 , pp. 526
    • Morikawa, K.1    Oseko, F.2    Morikawa, S.3
  • 12
    • 0023628475 scopus 로고
    • Immunosuppressive activities of deoxyspergualin. II. The effect on the antibody responses
    • MAKINO M, FUJIWARA M, WATANABE H, AOYAGI T, UMEZAWA H. Immunosuppressive activities of deoxyspergualin. II. The effect on the antibody responses. Immunopharmacology 1987:14:115.
    • (1987) Immunopharmacology , vol.14 , pp. 115
    • Makino, M.1    Fujiwara, M.2    Watanabe, H.3    Aoyagi, T.4    Umezawa, H.5
  • 13
    • 0025370931 scopus 로고
    • Evidence that deoxyspergualin prevents sensitization and first-set cardiac xenograft rejection in rats by suppression of antibody formation
    • VALDIVIA LA, MONDEN M, GOTOH M, NAKANO Y, TONO T, MORI T. Evidence that deoxyspergualin prevents sensitization and first-set cardiac xenograft rejection in rats by suppression of antibody formation. Transplantation 1990:50:132.
    • (1990) Transplantation , vol.50 , pp. 132
    • Valdivia, L.A.1    Monden, M.2    Gotoh, M.3    Nakano, Y.4    Tono, T.5    Mori, T.6
  • 14
    • 0023683392 scopus 로고
    • Xenogeneic transplantation. A review
    • AUCHINCLOSS H. Xenogeneic transplantation. A review. Transplantation 1988:46:1.
    • (1988) Transplantation , vol.46 , pp. 1
    • Auchincloss, H.1
  • 15
    • 0014889876 scopus 로고
    • Organ transplantation between widely disparate species
    • CALNE RY. Organ transplantation between widely disparate species. Transplant Proc 1970:2:550.
    • (1970) Transplant Proc , vol.2 , pp. 550
    • Calne, R.Y.1
  • 18
    • 0025611446 scopus 로고
    • Evidence that the immunosuppressive effects of FK506 and cyclosporin are identical
    • JOHANSSON A, MÖLLER E. Evidence that the immunosuppressive effects of FK506 and cyclosporin are identical. Transplantation 1990:50:1001.
    • (1990) Transplantation , vol.50 , pp. 1001
    • Johansson, A.1    Möller, E.2
  • 19
    • 0026090594 scopus 로고
    • FK506 and cyclosporin A inhibit highly similar signal transduction pathways in human T lymphocytes
    • LIN CS, BOLTZ RC, SIEKIERKA JJ, SIGAL NH. FK506 and cyclosporin A inhibit highly similar signal transduction pathways in human T lymphocytes. Cell Immunol 1991:133.
    • (1991) Cell Immunol , pp. 133
    • Lin, C.S.1    Boltz, R.C.2    Siekierka, J.J.3    Sigal, N.H.4
  • 20
    • 0021159379 scopus 로고
    • Cyclophilin: A specific cytosolic binding protein for cyclosporin A
    • HANDSCHUMACHER RE, HARDING MW, RICE J, DRUGGE RJ. Cyclophilin: a specific cytosolic binding protein for cyclosporin A. Science 1984:226:544.
    • (1984) Science , vol.226 , pp. 544
    • Handschumacher, R.E.1    Harding, M.W.2    Rice, J.3    Drugge, R.J.4
  • 21
    • 0024472603 scopus 로고
    • A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase
    • HARDING MW, GALAT A, UEHLING DE, SCHREIBER SL. A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase. Nature 1989:341:758.
    • (1989) Nature , vol.341 , pp. 758
    • Harding, M.W.1    Galat, A.2    Uehling, D.E.3    Schreiber, S.L.4
  • 22
    • 0024442393 scopus 로고
    • A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin
    • SIERKIERKA JJ, HUNG SHY, POE M, LIN CS, SIGAL NH. A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin. Nature 1989:341:755.
    • (1989) Nature , vol.341 , pp. 755
    • Sierkierka, J.J.1    Hung, S.H.Y.2    Poe, M.3    Lin, C.S.4    Sigal, N.H.5
  • 23
    • 0025893168 scopus 로고
    • Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
    • LIU J, FRAMER JD, LANE WS, FRIEDMAN J, WEISSMAN I, SCHREIBER SL. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 1991:66:807.
    • (1991) Cell , vol.66 , pp. 807
    • Liu, J.1    Framer, J.D.2    Lane, W.S.3    Friedman, J.4    Weissman, I.5    Schreiber, S.L.6
  • 24
    • 0026503434 scopus 로고
    • Calcineurin phosphatase activity in T lymphocytes is inhibited by FK506 and cyclosporin A
    • FRUMAN DA, KLEE CB, BIERER BE, BURAKOFF SJ. Calcineurin phosphatase activity in T lymphocytes is inhibited by FK506 and cyclosporin A. Proc Natl Acad Sci USA 1992:89:3686.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 3686
    • Fruman, D.A.1    Klee, C.B.2    Bierer, B.E.3    Burakoff, S.J.4
  • 25
    • 0025871394 scopus 로고
    • Nuclear association of a T-cell transcription factor blocked by FK506 and cyclosporin A
    • FLANAGAN WM, CORTHÉSY B, BRAM RJ, CRABTREE GR. Nuclear association of a T-cell transcription factor blocked by FK506 and cyclosporin A. Nature 1991:352:803.
    • (1991) Nature , vol.352 , pp. 803
    • Flanagan, W.M.1    Corthésy, B.2    Bram, R.J.3    Crabtree, G.R.4
  • 26
    • 0026643141 scopus 로고
    • Identification of calcineurin as a key signalling enzyme in T-lymphocytes activation
    • CLIPSTONE NA, CRABTREE GR. Identification of calcineurin as a key signalling enzyme in T-lymphocytes activation. Nature 1992:357:695.
    • (1992) Nature , vol.357 , pp. 695
    • Clipstone, N.A.1    Crabtree, G.R.2
  • 27
    • 0028116791 scopus 로고
    • Deoxyspergualin - A different and intriguing immunosuppressant
    • TUFVESSON G, GANNEDAHL G. Deoxyspergualin - a different and intriguing immunosuppressant. Transplant Proc 1994:26:3029.
    • (1994) Transplant Proc , vol.26 , pp. 3029
    • Tufvesson, G.1    Gannedahl, G.2
  • 28
    • 0028230782 scopus 로고
    • Quantitation of the interaction of the immunosuppressant deoxyspergualin and analogs with Hsc70 and Hsp90
    • NADEAU K, NADLER SG, SAULNIER M, TEPPER MA, WALSH CT. Quantitation of the interaction of the immunosuppressant deoxyspergualin and analogs with Hsc70 and Hsp90. Biochemistry 1994:33:2561.
    • (1994) Biochemistry , vol.33 , pp. 2561
    • Nadeau, K.1    Nadler, S.G.2    Saulnier, M.3    Tepper, M.A.4    Walsh, C.T.5
  • 29
    • 5544250030 scopus 로고
    • Pancreas islet transplantation
    • Thomas FD. Pancreas islet transplantation. Curr Surg 1991:48:343.
    • (1991) Curr Surg , vol.48 , pp. 343
    • Thomas, F.D.1
  • 30
    • 0027250094 scopus 로고
    • 15-deoxyspergualin prolongs pancreatic islet allo- and xenograft survival in mice
    • SANDBERG J-O, KORSGREN O, GROTH C-G, ANDERSSON A. 15-deoxyspergualin prolongs pancreatic islet allo- and xenograft survival in mice. Pharmacol Toxicol 1993:73:24.
    • (1993) Pharmacol Toxicol , vol.73 , pp. 24
    • Sandberg, J.-O.1    Korsgren, O.2    Groth, C.-G.3    Andersson, A.4
  • 31
    • 0022726985 scopus 로고
    • The influence of (±)-15-deoxyspergualin on experimental transplantation and its immunopharmacological mode of action
    • DICKNEITE G, SCHORLEMMER HU, WALTER P, THIES J, SEDLACEK HH. The influence of (±)-15-deoxyspergualin on experimental transplantation and its immunopharmacological mode of action. Behring Inst Mitt 1986:80:93.
    • (1986) Behring Inst Mitt , vol.80 , pp. 93
    • Dickneite, G.1    Schorlemmer, H.U.2    Walter, P.3    Thies, J.4    Sedlacek, H.H.5
  • 33
    • 0024909109 scopus 로고
    • Stability and immunosuppressive activity of deoxyspergualin in comparison with deoxymethylspergualin
    • FUJI H, TAKADA T, NEMOTO K, ABE F, TAKEUCHI T. Stability and immunosuppressive activity of deoxyspergualin in comparison with deoxymethylspergualin. Transplant Proc 1989:21:3471.
    • (1989) Transplant Proc , vol.21 , pp. 3471
    • Fuji, H.1    Takada, T.2    Nemoto, K.3    Abe, F.4    Takeuchi, T.5
  • 34
    • 0024413085 scopus 로고
    • Mechanism of action of 15-deoxyspergualin. I. Suppressive effect on the induction of alloreactive secondary cytotoxic T lymphocytes in vivo and in vitro
    • NISHIMURA K, TOKUNAGA T. Mechanism of action of 15-deoxyspergualin. I. Suppressive effect on the induction of alloreactive secondary cytotoxic T lymphocytes in vivo and in vitro. Immunology 1989:68:66.
    • (1989) Immunology , vol.68 , pp. 66
    • Nishimura, K.1    Tokunaga, T.2
  • 35
    • 0026052521 scopus 로고
    • Deoxyspergualin inhibits cytotoxic T lymphocytes but not NK or LAK cells
    • KERR PG, ATKINS RC. Deoxyspergualin inhibits cytotoxic T lymphocytes but not NK or LAK cells. Immunol Cell Biol 1991:69:177.
    • (1991) Immunol Cell Biol , vol.69 , pp. 177
    • Kerr, P.G.1    Atkins, R.C.2
  • 36
    • 0027184873 scopus 로고
    • 15-Deoxyspergualin, a novel immunosuppressive drug: Studies of the mechanism of action
    • TEPPER MA, NADLER S, MAZZUCCO C, SINGH C, KELLEY SL. 15-Deoxyspergualin, a novel immunosuppressive drug: studies of the mechanism of action. Ann NY Acad Sci 1993:685:136.
    • (1993) Ann NY Acad Sci , vol.685 , pp. 136
    • Tepper, M.A.1    Nadler, S.2    Mazzucco, C.3    Singh, C.4    Kelley, S.L.5
  • 37
    • 0026708538 scopus 로고
    • The in vitro immunosuppressive effect of deoxymethylspergualin in man as compared with FK506 and cyclosporine
    • TAKAHARA S, JIANG H, TAKANO Y, KOKADO Y, ISHOBASHI M, OKUYAMA A, SONODA T. The in vitro immunosuppressive effect of deoxymethylspergualin in man as compared with FK506 and cyclosporine. Transplantation 1992:53:914.
    • (1992) Transplantation , vol.53 , pp. 914
    • Takahara, S.1    Jiang, H.2    Takano, Y.3    Kokado, Y.4    Ishobashi, M.5    Okuyama, A.6    Sonoda, T.7
  • 38
    • 85033835545 scopus 로고    scopus 로고
    • 15-Deoxyspergualin inhibits interleukin-6 production in vitro stimulated human lymphocytes
    • in press
    • BORG AJ, KUMAGAI-BRAESCH M, MÖLLER E. 15-Deoxyspergualin inhibits interleukin-6 production in vitro stimulated human lymphocytes. Transplant Immunol., in press.
    • Transplant Immunol.
    • Borg, A.J.1    Kumagai-Braesch, M.2    Möller, E.3
  • 39
    • 0023847979 scopus 로고
    • B cell stimulatory factor-2 is involved in the differentiation of cytotoxic T lymphocytes
    • TAKAI Y, WONG GG, CLARK SC, BURAKOFF SJ, HERRMANN SH. B cell stimulatory factor-2 is involved in the differentiation of cytotoxic T lymphocytes. J. Immunol 1988:140:508.
    • (1988) J. Immunol , vol.140 , pp. 508
    • Takai, Y.1    Wong, G.G.2    Clark, S.C.3    Burakoff, S.J.4    Herrmann, S.H.5
  • 40
    • 0023803252 scopus 로고
    • Il-6/BSF-2 functions as a killer helper factor in the in vitro induction of cytotoxic T cells
    • OKADA M, KITAHARA M, KISHIMOTO S, MATSUDA T, HIRANO T, KISHIMOTO T. Il-6/BSF-2 functions as a killer helper factor in the in vitro induction of cytotoxic T cells. J Immunol 1988:141:1543.
    • (1988) J Immunol , vol.141 , pp. 1543
    • Okada, M.1    Kitahara, M.2    Kishimoto, S.3    Matsuda, T.4    Hirano, T.5    Kishimoto, T.6
  • 43
    • 0028022625 scopus 로고
    • Immunoregulatory effects of cytokines on natural killer cells
    • NAUME B, ESPEVIK T. Immunoregulatory effects of cytokines on natural killer cells. Scand J Immunol 1994:40:128.
    • (1994) Scand J Immunol , vol.40 , pp. 128
    • Naume, B.1    Espevik, T.2
  • 44
    • 0027731608 scopus 로고
    • Deoxyspergualin. Mode of action and clinical trials
    • SUZUKI S. Deoxyspergualin. Mode of action and clinical trials. Ann NY Acad Sci 1993:696:263.
    • (1993) Ann NY Acad Sci , vol.696 , pp. 263
    • Suzuki, S.1
  • 45
    • 0015370178 scopus 로고
    • The distribution of antibody and antibody-producing cells after immunization with xenogeneic cells
    • HARDING B, MACLENNAN I. The distribution of antibody and antibody-producing cells after immunization with xenogeneic cells. Immunology 1972:23:35.
    • (1972) Immunology , vol.23 , pp. 35
    • Harding, B.1    Maclennan, I.2
  • 46
    • 0016219285 scopus 로고
    • Effector mechanisms of cell-mediated immunity to xenogeneic antigens
    • DENNERT G. Effector mechanisms of cell-mediated immunity to xenogeneic antigens. J Immunol 1974:113:201.
    • (1974) J Immunol , vol.113 , pp. 201
    • Dennert, G.1
  • 47
    • 0015337030 scopus 로고
    • Specificity of lymphocyte-mediated cytotoxicity induced by in vitro antibody coated target cells
    • MÖLLER G, SVEHAG S. Specificity of lymphocyte-mediated cytotoxicity induced by in vitro antibody coated target cells. Cell Immunol 1974:4:1.
    • (1974) Cell Immunol , vol.4 , pp. 1
    • Möller, G.1    Svehag, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.