Displacement of RTI-55 from the dopamine transporter by cocaine

European Journal of Pharmacology

Volumn 296, Issue 2, 1996, Pages 145-151

  Gatley, S John ^a   Volkow, Nora D ^a   Chen, Ruoyan ^a   Fowler, Joanna S ^a   Carroll, F Ivy ^b   Kuhar, Michael J ^c  

^a BROOKHAVEN NATIONAL LABORATORY   (United States)

^b RTI INTERNATIONAL   (United States)

^c NIDA Addiction Research Center   (United States)

Author keywords

Cocaine analog; Mouse; Psychostimulant abuse; 123I RTI 55

Indexed keywords

3BETA (4 IODOPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; COCAINE; COCAINE DERIVATIVE; DOPAMINE TRANSPORTER; IODINE 123; RADIOLIGAND;

AMINE TRANSPORT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING COMPETITION; BRAIN REGION; CONTROLLED STUDY; CORPUS STRIATUM; DRUG ABUSE; DRUG UPTAKE; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LIGAND BINDING; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR OCCUPANCY;

EID: 0030034556     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(95)00698-2     Document Type: Article

References (34)

1. Balster, R.L. and C.R. Schuster, 1973, A comparison of D-amphetamine, L-amphetamine, and methamphetamine self-administration in rhesus monkeys, Pharmacol. Biochem. Behav. 1, 67.
2. 125I]RTI-55: a potent ligand for dopamine transporters, Eur. J. Pharmacol. 194, 133.
3. 125I]RTI-55 to dopamine and serotonin transporters in rat brain, Synapse 12, 27.
4. 3H]cocaine in striatum and its relationship to the dopamine transporter, Membrane Biochem. 7, 87.
5. Carroll, F.I, A.H. Lewin, J.W. Boja and M.J. Kuhar, 1992, Cocaine receptor: biochemical characterization and structure-activity relationships of cocaine analogues at the dopamine transporter, J. Med. Chem. 35, 969.
6. Carroll, F.I, P. Kotian, A. Dehghani, J.L. Gray, M.A. Kuzemko, K.A. Parham, P. Abraham, A.H. Lewin, J.W. Boja and M.J. Kuhar, 1995, Cocaine and 3β-(4′-substituted phenyl)tropane-2β-carboxylic acid ester and amide analogues. New high-affinity and selective compounds for the dopamine transporter, J. Med. Chem. 38, 379.
7. Chiodo, L.A., 1988, Dopamine-containing neurons in the mammalian central nervous system: electrophysiology and pharmacology, Neurosci. Biobehav. Rev. 12, 49.
8. Cline, E.J., U. Scheffel, J.W. Boja, F.I. Carroll, J.L. Katz and M.J. Kuhar, 1992, Behavioral effects of novel cocaine analogs: A comparison with in vivo receptor binding potency, J. Pharmacol. Exp. Ther. 258, 1174.
9. Deutsch, H.M. and M.M. Schweri, 1994, Can stimulant binding and dopamine transport be differentiated-studies with GBR-12783 derivatives, Life Sci. 55, 1115.
10. Deutsch, H.M., M.M. Schweri, C.T. Culbertson and L.H. Zalkow, 1992. Synthesis and pharmacology of irreversible affinity labels as potential cocaine antagonists: aryl 1,4-dialkylpiperazines related to GBR 12783, Eur. J. Pharmacol. 220, 173.
11. Dole, V.J., 1988, Implications of methadone maintenance for theories of narcotic addiction, J. Am. Med. Assoc. 260, 3025.
12. Fowler, J.S., N.D. Volkow, A.P. Wolf, S.L. Dewey, D.J. Schlyer and R.R. MacGregor, 1989, Mapping cocaine binding sites in human and baboon brain in vivo, Synapse 4, 371.
13. Galley, S.J., 1991, The activities of the enantiomers of cocaine, and some related compounds as substrates and inhibitors of plasma butyrylcholinesterase, Biochem. Pharmacol. 41, 1249.
14. Goodman-Gilman, A., L.S. Goodman, T.W. Rail and F. Murad, 1993. Goodman and Gilman's The Pharmacological Basis of Therapeutics (Macmillan, New York).
15. Innis, R.B., J.P. Seibyl, B.E. Scanley, M. Laruelle, A. Abi-Dargham, E. Wallace, R.M. Baldwin, Y. Zea-Ponce, S.S. Zoghbi, S. Wang, Y. Guo, J.L. Neumeyer, D.S. Charney, P.B. Hoffer and K.L. Marek, 1993, Single photon emission computed tomographic imaging demonstrates loss of striatal dopamine transporters in Parkinson disease, Proc. Natl. Acad. Sci. 90, 11965.
16. 3H]CFT, Synapse 9, 177.
17. Laruelle, M., R.M. Baldwin, R.T. Malison, Y. Zea-Ponce, S.S. Zoghbi, M. Al-Tikriti, E.H. Sybirska, R.C. Zimmermann, G. Wisniewski, J.L. Neumeyer, R.A. Milius, R.A. Wang, E.O. Smith, R.H. Roth, D. Charney, P.B. Hoffer and R.B. Innis, 1993, SPECT imaging of dopamine and serotonin transporters with [I-123] beta-CIT: pharmacological characterization of brain uptake in non-human primates, Synapse 13, 295.
18. 125I]iodophenyl)tropane-2β-carboxylate in vitro binding to dopamine and serotonin transporters under "physiological" conditions, J. Neurochem. 62, 978.
19. 123I]β-CIT binding to dopamine transporters in healthy human subjects, J. Cereb. Blood Flow Metab. 14, 982.
20. 125]RTI-55 binding to cocaine-sensitive dopaminergic and serotonergic uptake sites in the human brain, J. Neurochem. 61, 1996.
21. McElvain, J.S. and J.O. Schenk, 1992, A multisubstrate mechanism of striatal dopamine uptake and its inhibition by cocaine, Biochem. Pharmacol. 43, 2189.
22. 11C]β-CIT, a cocaine analog. Preparation, autoradiography and preliminary PET investigations, Nucl. Med. Biol. 20, 249.
23. Pan, D., R. Chen, S.J. Gatley, Y.-S. Ding and J.S. Fowler, in press, Iodine-123 labeled derivatives of methylphenidate: Potential SPECT radiopharmaceuticals for brain monoamine transporters, J. Label. Cmpds. Radiopharm.
24. Raynor, K., H. Kong, A. Mestek, L.S. Bye, M. Tian, J. Liu, L. Yu and Y. Reisine, 1995, Characterization of the cloned human mu opioid receptor, J. Pharmacol. Exp. Ther. 272, 423.
25. Ritz, M.C., R.J. Lamb, S.R. Goldberg and M.J. Kuhar, 1987, Cocaine receptors on dopamine transporters are related to self administration of cocaine, Science 237, 1219.
26. Rothman, R.B., 1990, High affinity dopamine reuptake inhibitors as potential cocaine antagonists: a strategy for drug development, Life Sci. 46, PL17.
27. 3H]paroxetine, J. Neurochem. 52, 1605.
28. 3H-WIN 35,428, Synapse 4, 390.
29. Seeman, P., 1993, Receptor Tables. Volume 2: Drug Dissociation Constants for Neuroreceptors and Transporters (SZ Research, Toronto).
30. Simoni, D., J. Stoelwinder, A.P. Kozikowski, K.M. Johnson, J.S. Bergmann and R.G. Ball, 1993, Methoxylation of cocaine reduces binding affinity and produces compounds of differential binding and dopamine uptake inhibitory activity: discovery of a weak cocaine "antagonist", J. Med. Chem. 36, 3975.
31. Spealman, R.D., R.T. Kelleher and S.R. Goldberg, 1983, Stereoselective effects of cocaine and a phenyltropane analog, J. Pharmacol. Exp. Ther. 225, 509.
32. Stathis, M., U. Scheffel, S.Z. Lever, J.W. Boja, F.I. Carroll and M.J. Kuhar, 1995, Rate of binding of various inhibitors at the dopamine transporter in vivo, Psychopharmacology 119, 376.
33. Volkow, N.D., Y.-S. Ding, J.S. Fowler, G.-J. Wang, J. Logan, S.J. Gatley, S. Dewey, C. Ashby, J. Liebermann, R. Hitzemann and A.P. Wolf, 1995, Is methylphenidate like cocaine? Studies on their pharmacokinetics and distribution in human brain, Arch. Gen. Psychiatry 52, 456.
34. Volkow, N.D., S.J. Gatley, J.S. Fowler, J. Logan, S.L. Dewey, Y.-S. Ding, R. Chen, N. Pappas, P. King, R.R. MacGregor, M.J. Kuhar, F.I. Carroll and A.P. Wolf, 1995, Long-lasting inhibition of in vivo cocaine binding to dopamine transporters by 3β-(4-iodophenyl)tropane-2-carboxylic acid methyl ester; RTI-55 or βCIT, Synapse 19, 206.