Pentoxifylline decreases brain levels of platelet activating factor in murine AIDS

European Journal of Pharmacology

Volumn 325, Issue 1, 1997, Pages 81-84

  Sei, Yoshitatsu ^a   Nishida, Keiji ^c   Kustova, Yelena ^a   Markey, Sandy P ^c   Morse III, Herbert C ^b   Basile, Anthony S ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

AIDS (acquired immunodeficiency syndrome); Encephalopathy; LP BM5 murine leukemia virus; PAF (platelet activating factor); Pentoxifylline; TNF (tumor necrosis factor )

Indexed keywords

PENTOXIFYLLINE; THROMBOCYTE ACTIVATING FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; BRAIN LEVEL; CONTROLLED STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; LEUKEMIA VIRUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; VIRUS INFECTION;

EID: 0030991762     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)89963-3     Document Type: Article

References (14)

1. Dezube B.J., Pardee A.B., Chapman B., Beckett L.A., Korvick J.A., Novick W.J., Chiurco J., Kasdan P., Ahlers C.M., Ecto L.T., Crumpacker C.S. The NIAID AIDS Clinical Trial Group, 1993. Pentoxifylline decreases tumor necrosis factor expression and serum triglycerides in people with AIDS. J. Acquired Immune Defic. Syndr. 6:1993;787-794.
2. Fonteh A.N., Winkler J.D., Torphy T.J., Heravi J., Undem B.J., Chilton F.H. Influence of isoproterenol and phosphodiesterase inhibitors on platelet-activating factor biosynthesis in the human neutrophil. J. Immunol. 151:1993;339-350.
3. Gelbard H.A., Nottet H.S.L.M., Swindells S., Jett M., Dzenko K.A., Genis P., White R., Wang L., Choi Y.-B., Zhang D., Lipton S.A., Tourtellotte W.W., Epstein L.G., Gendelman H.E. Platelet-activating factor: a candidate human immunodeficiency virus type 1-induced neurotoxin. J. Virol. 68:1994;4628-4635.
4. Genis P., Jett M., Bernton E.W., Gelbard H.A., Dzenko K., Keane R., Resnick L., Volsky D.J., Epstein L.G., Gendelman H.E. Cytokines and arachidonic acid metabolites produced during HIV-infected macrophage-astroglial interactions: implications for the neuropathogenesis of HIV disease. J. Exp. Med. 176:1992;1703-1718.
5. Kahn M.A., Ellison J.A., Speight G.J., De Villis J. CNTF regulation of astrogliosis and the activation of microglia in the developing rat central nervous system. Brain Res. 685:1995;55-67.
6. Kustova Y., Sei Y., Goping G., Basile A.S. Gliosis in the LP-BM5 murine leukemia virus-infected mouse: an animal model of retrovirus-induced dementia. Brain Res. 742:1997;271-282.
7. Morse H.C. III, Chattopadhyay S.K., Makino M., Fredrickson T., Hugin A.W., Hartley J.W. Retrovirus-induced immunodeficiency in the mouse: MAIDS as a model for AIDS. AIDS. 6:1992;607-621.
8. Nishida K., Markey P., Kustova Y., Morse H.C. III, Skolnick P., Basile A.S., Sei Y. Increased brain levels of platelet-activating factor in a murine acquired immune deficiency syndrome are NMDA receptor-mediated. J. Neurochem. 66:1996;433-435.
9. Piani D., Frei K., Do K.Q., Cuenod M., Fontana A. Murine brain macrophages induce NMDA receptor mediated neurotoxicity in vitro by secreting glutamate. Neurosci. Lett. 133:1991;159-162.
10. Sei Y., Arora P.K., Skolnick P., Paul I.A. Spatial learning impairment in a murine model of AIDS. FASEB J. 6:1992;3008-3013.
11. Sei Y., Paul I.A., Saito K., Layer R., Hartley J.W., Morse H.C. III, Skolnick P., Heyes M.P. Quinolinic acid levels in a murine retrovirus-induced immunodeficiency syndrome. J. Neurochem. 66:1996;296-302.
12. Sei Y., Whitesell L., Kustova Y., Paul I.A., Morse H.C. III, Skolnick P., Basile A.S. Altered brain fyn kinase in a murine acquired immunodeficiency syndrome. FASEB J. 10:1996;339-344.
13. Tozawa K., Sakurada S., Kohri K., Okamoto T. Effects of anti-nuclear factor κB reagents in blocking adhesion of human cancer cells to vascular endothelial cells. Cancer Res. 55:1995;4162-4167.
14. Wesselingh S.L., Power C., Glass J.D., Tyor W.R., McArthur J.C., Farber J.M., Griffin J.W., Griffin D.E. Intracerebral cytokine messenger RNA expression in acquired immune deficiency syndrome dementia. Ann. Neurol. 33:1993;576-582.