Lack of involvement of glutamate-induced excitotoxicity in MPP+ toxicity in striatal dopaminergic terminals: Possible involvement of ascorbate

British Journal of Pharmacology

Volumn 121, Issue 5, 1997, Pages 1038-1044

  Matarredona, Esperanza R ^a   Santiago, Marti ^a   Machado, Alberto ^a   Cano, Josefina ^a  

^a UNIVERSITY OF SEVILLE   (Spain)

Author keywords

1 methyl 4 phenylpyridinium; Ascorbate; Dopamine release; Glutamate uptake; Microdialysis; Rat striatum

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ASCORBIC ACID; DOPAMINE; EXCITOTOXIN; GLUTAMIC ACID; PYRROLIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE RELEASE; DOPAMINERGIC NERVE CELL; MALE; MICRODIALYSIS; NERVE ENDING; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

1-METHYL-4-PHENYLPYRIDINIUM; AMINO ACIDS, ESSENTIAL; ANIMALS; ASCORBIC ACID; ASPARTIC ACID; DICARBOXYLIC ACIDS; DOPAMINE; DOPAMINE AGENTS; EXTRACELLULAR SPACE; GLUTAMIC ACID; IMMUNOHISTOCHEMISTRY; MALE; MICRODIALYSIS; MPTP POISONING; NEOSTRIATUM; NERVE ENDINGS; NEUROTRANSMITTER UPTAKE INHIBITORS; PYRROLIDINES; RATS; RATS, WISTAR; TYROSINE 3-MONOOXYGENASE;

EID: 0030987374     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701216     Document Type: Article

References (47)

1. BRIDGES, R.J., STANLEY, M.S., ANDERSON, M.W., COTMAN, C.W. & CHAMBERLIN, R. (1991). Conformationally defined neurotransmitter analogues. Selective inhibition of glutamate uptake by one pyrrolidine-2,4,-dicarboxylate diastereomer. J. Med. Chem., 34, 717-724.
2. BROUILLET, E. & BEAL, M.F. (1993). NMDA antagonists partially protect MPTP induced neurotoxicity in mice. NeuroReport, 4, 387-390.
3. CAMMACK, J., GHASEMZADEH, B. & ADAMS, R.N. (1991). The pharmacological profile of glutamate-evoked ascorbic acid eflux measured by in vivo electrochemistry. Brain Res., 565, 17-22.
4. +). Neurosci. Lett., 117, 129-133.
5. CARROZZA, D.P., FERRARO, T.N., GOLDEN, G.T., REYES, P.F. & HARE, T.A. (1991). Partial characterization of kainic acid-induced striatal dopamine release using in vivo microdialysis. Brain Res., 543, 69-76.
6. CHAN, P., DELANNEY, L.E., IRWIN, I., LANGSTON, J.W. & DI MONTE, D. (1991). Rapid ATP loss caused by MPTP in mouse brain. J. Neurochem., 57, 348-351.
7. + elimination in the mouse striatum. J. Pharmacol. Exp. Ther., 267, 1515-1520.
8. +: possible action at the dopamine transporter. Br. J. Pharmacol., 114, 315-322.
9. CLOW, D.W. & JHAMANDAS, K. (1989). Characterization of L-glutamate action on the release of endogenous dompamine from the rat caudade-putamen. J. Pharmacol. Exp. Ther., 248, 722-728.
10. DIJK, S.N., KROP-VAN GASTEL, W., OBRENOVITCH, T.P. & KORF, J. (1994). Food deprivation protects the rat striatum against hypoxia-ischemia despite high extracellular glutamate. J. Neurochem., 62, 1847-1851.
11. FILLENZ, M. & GRÜNEWALD, R.A. (1984). Release of ascorbate from a synaptosomal fraction of a rat brain. Neurochem. Int., 6, 491-500.
12. FINIELS-MARLIER, F., MARINI, A.M., WILLIAMS, P. & PAUL, S.M. (1993). The N-methyl-D-aspartate antagonist MK-801 fails to protect dopaminergic neurons from MPTP toxicity in vitro. J. Neurochem., 60, 1968-1971.
13. GIBB, J.W., JOHNSON, M. & HANSON, G.R. (1990). Neurochemical basis of neurotoxicity. Neurotoxicology, 11, 317-321.
14. GRÜNEWALD, R.A. (1993). Ascorbic acid in the brain. Brain Res. Rev., 18, 123-133.
15. HALLIWELL, B. (1996). Vitamin C: antioxidant or prooxidant in vivo?. Free Rad. Res., 25, 439-454.
16. KEHRER, J.P. (1993). Free radicals as mediators of tissue injury and disease. Crit. Rev. Toxicol., 23, 21-48.
17. KUPSCH, A., LOSCHMANN, P.A., SAVER, H., ARNOLD, G., RENNER, P., PUFAL, D., BURG, M., WACHTEL, H., TEN BRUGGENCATE, G. & OERTEL, W.H. (1992). Do NMDA receptor antagonists protect against MPTP-toxicity? Biochemical and immunocytochemical analyses in black mice. Brain Res., 592, 74-83.
18. LAPCHACK, P.A. & HEFTI, F. (1992). BDNF and NGF in lesioned rats: effects on cholinergic function and weight gain. NeuroReport, 3, 405-408.
19. LEVIEL, V., GOBERT, A. & GUIBERT, B. (1990). The glutamate-mediated release of dopamine in the rat striatum: further characterization of the dual excitatory-inhibitory function. Neuroscience, 39, 305-312.
20. LI, C.-L., WERNER, P. & COHEN, G. (1995). Lipid peroxidation in brain: interactions of L-DOPA/Dopamine with ascorbate and iron. Neurodegeneration, 4, 147-153.
21. MAREK, G.J., VOSMER, G. & SEIDEN, L.S. (1990). Dopamine uptake inhibitors block long-term neurotoxic effects of methamphetamine upon dopaminergic neurons. Brain Res., 513, 274-279.
22. MARTIN, F.R., SANCHEZ-RAMOS, J. & ROSENTHAL, M. (1991). Selective and non selective effects of MPTP on oxygen consumption in rat striatal and hippocampal slices. J. Neurochem., 57, 1340-1346.
23. MASSIEU, L., MORALES-VILLAGRAN, A. & TAPIA, R. (1995). Accumulation of extracelular glutamate by inhibition of its uptake is not sufficient for inducing neuronal damage: An in vivo microdialysis study. J. Neurochem., 64, 2262-2272.
24. MIELE, M., BOUTELLE, M.G. & FILLENZ, M. (1994). The physiologically induced release of ascorbate in rat brain is dependent on impulse traffic, calcium influx and glutamate uptake. Neuroscience, 62, 87-91.
25. MITANI, A., ANDOU, Y. & KATASKA, K. (1992). Selective vulnerability of hippocampal CA1 neurons cannot be explained in terms of an increase in glutamate concentration during ischemia in the gerbil: a microdialysis study. Neuroscience, 48, 307-313.
26. OLNEY, J.W. (1989). Excitatory amino acids and neuropsychiatria disorders. Biol. Psychiat., 26, 505-525.
27. OLNEY, J.W. (1990). Excitotoxicity and ischemic brain damage in infancy and adulthood. In Pharmacology of Cerebral Ischemia. ed. Krieglstein, J. & Oberpichler, H. pp. 153-167. Stuttgart: Wissenschaftliche Verlagsgesellschaft MbH.
28. PAXINOS, G. & WATSON, C. (1986). The Rat Brain in Sterotaxic Coordinates. San Diego: Academic Press.
29. PERRY, T.L., YONG, V.W., ITO, M., JONES, K., WALL, R.A., FOULKS, J.G., WRYGHT, J.M. & KISH, S.J. (1985). MPTP does not destroy nigrostriatal neurons in the scorbutic guinea pig. Life Sci., 36, 1233-1238.
30. PIERCE, R.C. & REBEC, G.V. (1992). Dopamine-, NMDA-, and sigma-receptor antagonists exert differential effects on basal and amphetamine-induced changes in neostriatal ascorbate and DOPAC in awake, behaving rats. Brain Res., 579, 59-76.
31. PIERCE, R.C. & REBEC, G.V. (1993). Intraneostriatal administration of glutamate antagonist increases behavioural activation and decreases neostriatal ascorbate via nondopaminergic mechanism. J. Neurosci., 13, 4272-4280.
32. +) and its analogs with the rotenone/ piericidin binding site of NADH dehydrogenase. J. Neurochem., 56, 1184-1190.
33. REBEC, G.V. & PIERCE, R.C. (1994). A vitamin as neuromodulator: ascorbate release into extracellular fluid of the brain regulates dopaminergic and glutamatergic transmission. Prog. Neurobiol., 43, 537-565.
34. + neurotoxicity on striatal slices from guinea-pigs fed with a vitamin C lacking diet. Neuroscience, 77, 167-174.
35. RIEDERER, P. & YOUDIM, M.B.H. (1986). Monoamine oxidase activity and monoamine metabolism in brains of parkinsonian patients treated with 1-deprenyl. J. Neurochem., 46, 1359-1365.
36. + toxicity on striatal dopaminergic terminals. J. Neurochem., 68, 732-738.
37. + neurotoxicity by N-methyl-D-aspartate antagonists. Brain Res., 586, 203-207.
38. SANTIAGO, M. & WESTERINK, B.H.C. (1990). Characterization of the in vivo release of dopamine as recorded by different types of intracerebral microdialysis probes. Naunyn-Schmiedeberg's Arch. Pharmacol., 342, 407-414.
39. SONSALLA, P.K., NICKLAS, W.J. & HEIKKILA, R.E. (1989). Role for excitatory amino acids in methamphetamine-induced nigrostriatal dopaminergic toxicity. Science, 243, 398-400.
40. SONSALLA, P.K., ZEEVALK, G.D., MANZINO, L., GIOVANNI, A. & NICKLAS, W.J. (1992). MK-801 fails to protect against the dopaminergic neuropathology produced by systemic MPTP in mice or intranigral MPTP in rats. J. Neurochem., 58, 1979-1982.
41. +) nigral toxicity in the rat by prior decortication of MK-801 treatment: a stereological estimate of neuronal loss. Neurobiol. Aging, 14, 295-301.
42. + produces excitotoxic lesions in rat striatum as a result of impairment of oxidative metabolism. J. Neurochem., 58, 1975-1978.
43. + neurotoxicity by N-methyl-D-aspartate antagonists. Nature, 349, 414-418.
44. + depleting effect on dopamine levels in rat striatal slices. Neurochem. Int., 29, 411-416.
45. WALKER, M.C., GALLEY, P.T., ERRINGTON, M.L., SHORVON, S.D. & JEFFERYS, J.G.R. (1995). Ascorbate and glutamate release in the rat hippocampus after perforant path stimulation: A 'dialysis electrode' study. J. Neurochem., 65, 725-731.
46. WESTERINK, B.H.C., DAMSMA, G., ROLLEMA, H., DE VRIES, J.B. & HORN, A.S. (1987). Scope and limitations of in vivo brain dialysis: a comparison of its application to various neurotransmitter systems. Life Sci., 41, 1763-1776.
47. ZUDDAS, A., OBERTO, G., VAGLINI, F., FASCETTI, F., FORNAI, F. & CORSINI, G.V. (1992). MK-801 prevents MPTP-induced parkinsonism in primates. J. Neurochem., 59, 733-739.