Elevation of cyclic AMP levels in astrocytes antagonizes cytokine- induced adhesion molecule expression

Journal of Neurochemistry

Volumn 69, Issue 4, 1997, Pages 1438-1448

  Ballestas, Mary E ^a   Benveniste, Etty N ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Astrocytes; Cytokines; Intercellular adhesion molecule 1; Second messengers; Vascular cell adhesion molecule 1

Indexed keywords

BUCLADESINE; CHOLERA TOXIN; FORSKOLIN; INTERCELLULAR ADHESION MOLECULE 1; NORADRENALIN; PROSTAGLANDIN E2; RECOMBINANT INTERLEUKIN 1BETA; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; ROLIPRAM; VASCULAR CELL ADHESION MOLECULE 1;

ARTICLE; ASTROCYTE; CELL ADHESION; CONTROLLED STUDY; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; NERVE CELL CULTURE; PRIORITY JOURNAL; SECOND MESSENGER;

EID: 0030985408     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.69041438.x     Document Type: Article

References (59)

1. Archelos J. J., Jung S., Mäurer M., Schmied M., Lassmann H., Tamatani T., Miyasaka M., Toyka K. V., and Hartung H.-P. (1993) Inhibition of experimental autoimmune encephalomyelitis by an antibody to the intercellular adhesion molecule ICAM-1. Ann. Neurol. 34, 145-154.
2. Ballestas M. E. and Benveniste E. N. (1995) Interleukin-1β and tumor necrosis factor-α mediated regulation of ICAM-1 gene expression in astrocytes requires protein kinase C activity. Glia 14, 267-278.
3. Barten D. M. and Ruddle N. H. (1994) Vascular cell adhesion molecule-1 modulation by tumor necrosis factor in experimental allergic encephalomyelitis. J. Neuroimmunol. 51, 123-133.
4. 2 inhibits production of Th1 lymphokines but not of Th2 lymphokines. J. Immunol. 146, 108-113.
5. Bignami A., Eng L. F., Dahl D., and Uyeda C. T. (1972) Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence, Brain Res. 43, 429-435.
6. Bö L., Peterson J. W., Mork S., Hoffman P. A., Gallatin W. M., Ransohoff R. M., and Trapp B. D. (1996) Distribution of immunoglobulin superfamily members ICAM-1, -2, -3, and the β2 integrin LFA-1 in multiple sclerosis lesions. J. Neuropathol. Exp. Neurol. 55, 1060-1072.
7. Cannella B. and Raine C. S. (1995) The adhesion molecule and cytokine profile of multiple sclerosis lesions. Ann. Neurol. 37, 424-435.
8. Carlos T. M. and Harlan J. M. (1994) Leukocyte-endothelial adhesion molecules. Blood 84, 2068-2101.
9. 7, on the human B cell line JY. J. Biol. Chem. 267, 8366-8370.
10. Chen D. and Rothenberg E. V. (1994) Interleukin 2 transcription factors as molecular targets of cAMP inhibition: delayed inhibition kinetics and combinatorial transcription roles. J. Exp. Med. 179, 931-942.
11. Chung I. Y. and Benveniste E. N. (1990) Tumor necrosis factor-α production by astrocytes: induction by lipopolysaccharide, IFN-γ and IL-1β. J. Immunol. 144, 2999-3007.
12. Collins T., Read M. A., Neish A. S., Whitley M. Z., and Thanos D. (1995) Transcriptional regulation of endothelial cell adhesion molecules: NF-κB and cytokine-inducible enhancers. FASEB J. 9, 899-909.
13. Cooper D. M. F., Mons N., and Karpen J. W. (1995) Adenylyl cyclases and the interaction between calcium and cAMP signalling. Nature 374, 421-424.
14. + T lymphocytes. Proc. Natl. Acad. Sci. USA 88, 6403-6407.
15. + T lymphocytes. J. Immunol. 148, 1985-1992.
16. + T lymphocytes. J. Immunol. 151, 2368-2379.
17. Diamond M. S., Staunton D. E., Marlin S. D., and Springer T. A. (1991) Binding of the integrin Mac-1 (CD11b/CD18) to the third immunoglobulin-like domain of ICAM-1 (CD54) and its regulation by glycosylation. Cell 65, 961-971.
18. Elices M. J., Osborn L., Takada Y., Crouse C., Luhowskyj S., Hemler M. E., and Lobb R. R. (1990) VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell 60, 577-584.
19. Fries J. W. U., Williams A. J., Atkins R. C., Newman W., Lipscomb M. F., and Collins T. (1993) Expression of VCAM-1 and E-selectin in an in vivo model of endothelial activation. Am. J. Pathol. 143, 725-737.
20. Genain C. P., Roberts T., Davis R. L., Nguyen M.-H., Uccelli A., Faulds D., Li Y., Hedgpeth J., and Hauser S. L. (1995) Prevention of autoimmune demyelination in non-human primates by a cAMP-specific phosphodiesterase inhibitor. Proc. Natl. Acad. Sci. USA 92, 3601-3605.
21. Ghersa P., van Huijsduijnen R. H., Whelan J., Cambet Y., Pescini R., and DeLamarter J. F. (1994) Inhibition of E-selectin gene transcription through a cAMP-dependent protein kinase pathway. J. Biol. Chem. 269, 29129-29137.
22. Grimaldi M., Pozzoli G., Navarra P., Preziosi P., and Schettini G. (1994) Vasoactive intestinal peptide and forskolin stimulate interleukin 6 production by rat cortical astrocytes in culture via a cyclic AMP-dependent, prostaglandin-independent mechanism. J. Neurochem. 63, 344-350.
23. Iademarco M. F., Barks J. L., and Dean D. C. (1995) Regulation of vascular cell adhesion molecule-1 expression by IL-4 and TNF-α in cultured endothelial cells. J. Clin. Invest. 95, 264-271.
24. Jung S., Zielasek J., Köllner G., Donhauser T., Toyka K., and Hartung H.-P. (1996) Preventive but not therapeutic application of rolipram ameliorates experimental autoimmune encephalomyelitis in Lewis rats. J. Neuroimmunol. 68, 1-11.
25. Kambayashi T., Jacob C. O., Zhou D., Mazurek N., Fong M., and Strassmann G. (1995) Cyclic nucleotide phosphodiesterase type IV participates in the regulation of IL-10 and in the subsequent inhibition of TNF-α and IL-6 release by endotoxin-stimulated macrophages. J. Immunol. 155, 4909-4916.
26. Kammer G. M. (1988) The adenylate cyclase-cAMP-protein kinase A pathway and regulation of the immune response. Immunol. Today 9, 222-229.
27. Karin M. (1992) Signal transduction from cell surface to nucleus in development and disease. FASEB J. 6, 2581-2590.
28. Kawai K., Kobayashi Y., Shiratori M., Sobue G., Tamatani T., Miyasaka M., and Yoshikai Y. (1996) Intrathecal administration of antibodies against LFA-1 and against ICAM-1 suppresses experimental allergic encephalomyelitis. Cell. Immunol. 171, 262-268.
29. Kobayashi Y., Kawai K., Honda H., Tomida S., Niimi N., Tamatani T., Miyasaka M., and Yoshikai Y. (1995) Antibodies against leukocyte function-associated antigen-1 and against intercellular adhesion molecule-1 together suppress the progression of experimental allergic encephalomyelitis. Cell. Immunol. 164, 295-305.
30. Kwon J., Lee S. J., and Benveniste E. N. (1996) A 3′ cis-acting element is involved in tumor necrosis factor-α gene expression in astrocytes. J. Biol. Chem. 271, 22383-22390.
31. Merrill J. E. and Benveniste E. N. (1996) Cytokines in inflammatory brain lesions: helpful and harmful. Trends Neurosci. 19, 331-338.
32. Morrissey S. P., Deichmann R., Syha J., Simonis C., Zettl U., Archelos J. J., Jung S., Stodal H., Lassmann H., Toyka K. V., Haase A., and Hartung H.-P. (1996) Partial inhibition of AT-EAE by an antibody to ICAM-1: clinico-histological and MRI studies. J. Neuroimmunol. 69, 85-93.
33. Neish A. S., Read M. A., Thanos D., Pine R., Maniatis T., and Collins T. (1995) Endothelial interferon regulatory factor 1 cooperates with NF-κB as a transcriptional activator of vascular cell adhesion molecule 1. Mol. Cell. Biol. 15, 2558-2569.
34. Neumann M., Grieshammer T., Chuvpilo S., Kneitz B., Lohoff M., Schimpl A., Franza B. R. Jr., and Serfling E. (1995) Re1A/p65 is a molecular target for the immunosuppressive action of protein kinase A. EMBO J. 14, 1991-2004.
35. Norris J. G. and Benveniste E. N. (1993) Interleukin-6 production by astrocytes: induction by the neurotransmitter norepinephrine. J. Neuroimmunol. 45, 137-146.
36. Norris J. G., Tang L.-P., Sparacio S. M., and Benveniste E. N. (1994) Signal transduction pathways mediating astrocyte IL-6 induction by IL-1β and tumor necrosis factor-α. J. Immunol. 152, 841-850.
37. Nottet H. S. L. M., Persidsky Y., Sasseville V. G., Nukuna A. N., Bock P., Zhai Q.-H., Sharer L. R., McComb R., Swindells S., Soderland C., and Gendelman H. E. (1996) Mechanisms for the transendothelial migration of HIV-1-infected monocytes into brain. J. Immunol. 156, 1284-1295.
38. Ochi H., Kume N., Nishi E., and Kita T. (1995) Elevated levels of cAMP inhibit protein kinase C-independent mechanisms of endothelial platelet-derived growth factor-B chain and intercellular adhesion molecule-1 gene induction by lysophosphatidylcholine. Circ. Res. 77, 530-535.
39. Ollivier V., Parry G. C. N., Cobb R. R., de Prost D., and Mackman N. (1996) Elevated cyclic AMP inhibits NF-κB-mediated transcription in human monocytic cells and endothelial cells. J. Biol. Chem. 271, 20828-20835.
40. Panettieri R. A. Jr., Lazzaar A. L., Puré E., and Albelda S. M. (1995) Activation of cAMP-dependent pathways in human airway smooth muscle cells inhibits TNF-α-induced ICAM-1 and VCAM-1 expression and T lymphocyte adhesion. J. Immunol. 154, 2358-2365.
41. Pober J. S., Slowik M. R., De Luca L. G., and Ritchie A. J. (1993) Elevated cyclic AMP inhibits endothelial cell synthesis and expression of TNF-induced endothelial leukocyte adhesion molecule-1, and vascular cell adhesion molecule-1, but not intercellular adhesion molecule-1. J. Immunol. 150, 5114-5123.
42. Rappaport R. S. and Dodge G. R. (1982) Prostaglandin E inhibits the production of human interleukin 2. J. Exp. Med. 155, 943-948.
43. Reeves M. L., Keigh B. K., and England P. J. (1987) The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors. Biochem. J. 241, 535-541.
44. Satriano J. and Schlondorff D. (1994) Activation and attenuation of transcription factor NF-κB in mouse glomerular mesangial cells in response to tumor necrosis factor-α, immunoglobulin G, and adenosine 3́:5́-cyclic monophosphate. Evidence for involvement of reactive oxygen species. J. Clin. Invest. 94, 1629-1636.
45. Semmler J., Wachtel H., and Endres S. (1993) The specific type IV phosphodiesterase inhibitor rolipram suppresses tumor necrosis factor-α production by human mononuclear cells. Int. J. Immunopharmacol. 15, 409-413.
46. Shrikant P., Chung I. Y., Ballestas M., and Benveniste E. N. (1994) Regulation of intercellular adhesion molecule-1 gene expression by tumor necrosis factor-α, interleukin-1β, and interferon-γ in astrocytes. J. Neuroimmunol. 51, 209-220.
47. Shrikant P., Weber E., Jilling T., and Benveniste E. N. (1995) ICAM-1 gene expression by glial cells: differential mechanisms of inhibition by interleukin-10 and interleukin-6. J. Immunol. 155, 1489-1501.
48. Shrikant P., Lee S. J., Kalvakalanu I., Ransohoff R. M., and Benveniste E. N. (1996) Stimulus-specific inhibition of ICAM-1 gene expression by TGF-β. J. Immunol. 157, 892-900.
49. Sligh J. E. Jr., Ballantyne C. M., Rich S. S., Hawkins H. K., Smith C. W., Bradley A., and Beaudet A. L. (1993) Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1. Proc. Natl. Acad. Sci. USA 90, 8529-8533.
50. Sobel R. A., Mitchell M. E., and Fondren G. (1990) Intercellular adhesion molecule-1 (ICAM-1) in cellular immune reactions in the human central nervous system. Am. J. Pathol. 136, 1309-1316.
51. Sommer N., Loschmann P.-A., Northoff G. H., Weller M., Steinbrecher A., Steinbach J. P., Lichtenfels R., Meyermann R., Riethmüller A., Fontana A., Dichgans J., and Martin R. (1995) The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis. Nat. Med. 1, 244-248.
52. Sparacio S. M., Zhang Y., Vilcek J., and Benveniste E. N. (1992) Cytokine regulation of interleukin-6 gene expression in astrocytes involves activation of an NF-κB-like nuclear protein. J. Neuroimmunol. 39, 231-242.
53. Springer T. A. (1994) Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76, 301-314.
54. Staunton D. E., Marlin S. D., Stratowa C., Dustin M. L., and Springer T. A. (1988) Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families. Cell 52, 925-933.
55. Steffen B. J., Butcher E. C., and Engelhardt B. (1994) Evidence for involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL/j mouse. Am. J. Pathol. 145, 189-201.
56. van de Stolpe A. and van der Saag P. T. (1996) Intercellular adhesion molecule-1. J. Mol. Med. 74, 13-33.
57. Wertheimer S. J., Myers C. L., Wallace R. W., and Parks T. P. (1992) Intercellular adhesion molecule-1 gene expression in human endothelial cells. J. Biol. Chem. 267, 12030-12035.
58. Wölle J., Hill R. R., Ferguson E., Devall L. J., Trivedi B. K., Newton R. S., and Saxena U. (1996) Selective inhibition of tumor necrosis factor-induced vascular cell adhesion molecule-1 gene expression by a novel flavonoid: lack of effect on transcription factor NF-κB. Arterioscler. Thromb. Vasc. Biol. 16, 1501-1508.
59. Yednock T. A., Cannon C., Fritz L. C., Sanchez-Madrid F., Steinman L., and Karin N. (1992) Prevention of experimental autoimmune encephalomyelitis by antibodies against α4β1 integrin. Nature 356, 63-66.