Mapping of mouse obesity genes: A generic approach to a complex trait

Journal of Nutrition

Volumn 127, Issue 9, 1997, Pages

  Fisler, Janis S ^a,c   Warden, Craig H ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NONE   (United States)

Author keywords

Genetics; Percentage body fat

Indexed keywords

ADENOSINE; ADRENERGIC RECEPTOR; CARBOXYPEPTIDASE H; CHOLESTEROL; COMPLEMENTARY DNA; CORTICOSTERONE; CORTICOTROPIN; CYTOSINE; DNA; FAT; GLUCOCORTICOID RECEPTOR; GLYCEROL 3 PHOSPHATE DEHYDROGENASE; LEPTIN; NEUROHORMONE; PROINSULIN; PROTEIN; RECEPTOR; SEROTONIN 1C RECEPTOR; SOMATOMEDIN B; SULFOTRANSFERASE; TRANSFORMING GROWTH FACTOR ALPHA;

ADIPOCYTE; BODY FAT; BODY WEIGHT; CONFERENCE PAPER; GENE; GENE MAPPING; GENOTYPE; HUMAN; NONHUMAN; OBESITY; PHENOTYPE; POLYMERASE CHAIN REACTION; PROGENY; QUANTITATIVE TRAIT; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK; WEIGHT GAIN; Y CHROMOSOME;

EID: 0030984073     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/127.9.1909s     Document Type: Conference Paper

References (78)

1. Andersson, L., Haley, C. S., Ellegren, H., Knott, S. A., Johansson, M., Andersson, K., Andersson-Eklund, L., Edfors-Lilja, I., Fredholm, M., Hansson, I., Håkansson, J. & Lundström, K. (1994) Genetic mapping of quantitative trait loci for growth and fatness in pigs. Science (Washington, DC) 263: 1771-1774.
2. Bailey, D. W. (1975) Genetics of histocompatibility in mice: I. New loci and congenic lines. Immunogenetics 2: 249-256.
3. Bultman, S. J., Michaud, E. J. & Woychik, R. P. (1992) Molecular characterization of the mouse agouti locus. Cell 71: 1195-1204.
4. Cheverud, J. M., Routman, E. J., Duarte, F. A., van Swinderen, B., Cothran, K. & Perel, C. (1996) Quantitative trait loci for murine growth. Genetics 142: 1305-1319.
5. Clamp, P. A., Beever, J. E., Fernando, R. L., McLaren, D. G. & Schook, L. B. (1972) Detection of linkage between genetic markers and genes that affect growth and carcass traits in pigs. J. Anim. Sci. 70: 2695-2706.
6. Clark, J. S., Jeffs, B., Davidson, A. O., Lee, W. K., Anderson, N. H., Bihoreau, M. T., Brosnan, M. J., Devlin, A. M., Kelman, A. W., Lindpainter, K. & Dominiczak, A. F. (1996) Quantitative trait loci in genetically hypertensive rats. Possible sex specificity. Hypertension 28: 898-906.
7. Clement, K., Vaisse, C., Manning, B.S.J., Basdevant, A., Guy-Grand, B., Ruiz, J., Silver, K. D., Shuldiner, A. R., Froguel, P. & Strosberg, A. D. (1995) Genetic variation in the beta3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. N. Engl. J. Med. 333: 352-354.
8. Coleman, D. L. & Eicher, E. M. (1990) Fat (fat) and tubby (tub): two autosomal recessive mutations causing obesity syndromes in the mouse. J. Hered. 81: 424-427.
9. Collins, A. C., Martin, I. C. & Kirkpatrick, B. W. (1993) Growth quantitative trait loci (QTL) on mouse chromosome 10 in a Quackenbush-Swiss x C57BL/6J backcross. Mammalian Genome 4: 454-458.
10. Copeland, N. G., Jenkins, N. A., Gilbert, D. J., Eppig, J. T., Maltais, L. J., Miller, J. C., Dietrich, W. F., Weaver, A., Lincoln, S. E., Steen, R. G., Stein, L. D., Nadeau, J. H. & Lander, E. S. (1993) A genetic linkage map of the mouse: current applications and future prospects. Science (Washington, DC) 262: 57-66.
11. Deng, A. Y., Dene, H. & Rapp, J. P. (1994) Mapping of a quantitative trait locus for blood pressure on rat chromosome 2. J. Clin. Invest. 94: 431-436.
12. Dietrich, W., Katz, H., Lincoln, S. E., Shin, H.-S., Friedman, J., Dracopoli, N. C. & Lander, E. S. (1992) A genetic map of the mouse suitable for typing intra-specific crosses. Genetics 131: 423-447.
13. Dragani, T. A., Zeng, Z. B., Canzian, F., Gariboldi, M., Ghilarducci, M. T., Manenti, G. & Pierotti, M. A. (1995) Mapping of body weight loci on mouse chromosome X. Mammalian Genome 6: 778-781.
14. Fijneman, F. J., de Vries, S. S., Jansen, R. C. & Demant, P. (1996) Complex interactions of new quantitative trait loci, Sluc1, Sluc2, Sluc3, and Sluc4, that influence the susceptibility to lung cancer in the mouse. Nat. Genet. 14: 465-467.
15. Fisler, J. S., Warden, C. H., Pace, M. J. & Lusis, A. J. (1993) BSB: a new mouse model of multigenic obesity. Obes. Res. 1: 271-280.
16. Fleury, C., Neverova, M., Collins, S., Raimbault, S., Champigny, O., Levi-Meyrueis, C., Bouillaud, F., Seidin, M. F., Surwit, R. S., Ricquier, D. & Warden, C. H. (1997) Uncoupling protein-2: a novel gene linked to obesity and hyperinsu-linemia. Nat. Genet. 15: 269-272.
17. Frankel, W. N. (1995) Taking stock of complex trait genetics in mice. Trends Genet. 11: 471-477.
18. Frankel, W. N., Johnson, E. W. & Lutz, C. M. (1995a) Congenic strains reveal effects of the epilepsy quantitative trait locus, EI2, separate from other EI loci. Mammalian Genome 6: 839-843.
19. Frankel, W. N., Valenzuela, A., Lutz, C. M., Johnson, E. W., Dietrich, W. F. & Coffin, J. M. (1995b) New seizure frequency QTL and the complex genetics of epilepsy in EL mice. Mammalian Genome 6: 830-838.
20. Friedman, J. M., Leibel, R. L., Bahary, N., Siegel, D. A. & Truett, G. (1991) Genetic analysis of complex disorders: molecular mapping of obesity genes in mice and humans. Ann. N.Y. Acad. Sci. 630: 100-115.
21. Gnudi, L., Tozzo, E., Shepherd, P. R., Bliss, J. L. & Khan, B. B. (1995) High level overexpression of glucose transporter-4 driven by an adipose-specific promoter is maintained in transgenic mice on a high fat diet, but does not prevent impaired glucose tolerance. Endocrinology 136: 995-1002.
22. Graff, R. J. & Snell, G. D. (1968) Histocompatibility genes of mice: VIII. The alleles of the H-1 locus. Transplantation 6: 598-617.
23. Hastings, I. M. & Veerkamp, R. F. (1993) The genetic basis of response in mouse lines divergently selected for body weight or fat content. I. The relative contributions of autosomal and sex-linked genes. Genet. Res. 62: 169-175.
24. Hubert, P., Lindpaintner, K., Beckmann, J. S., Serikawa, T., Soubrier, F., Dubay, C., Cartwright, P., De Gouyon, B., Julier, C., Takahasi, S., Vincent, M., Ganten, D., Georges, M. & Lathrop, G. M. (1991) Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats. Nature (Lond.) 353: 521-529.
25. Hochberg, Z., Hertz, P., Varda, C., Ish-Shalom, S., Yeshuran, D., Youdim, M.B.H. & Amit, T. (1992) The distal axis of growth hormone (GH) in nutritional disorders: GH binding protein, insulin-like growth factor-1 (IGF-1) and IGF-1 receptors in obesity and anorexia nervosa. Metabolism 41: 106-112.
26. Hofstetter, J. R., Mayeda, A. R., Possidente, B. & Nurnberger, J. I., Jr. (1995) Quantitative trait loci (QTL) for circadian rhythms of locomotor activity in mice. Behav. Genet. 25: 545-556.
27. Hyman, R. W., Frank, S., Warden, C. H., Daluiski, A., Heller, R. & Lusis, A. J. (1994) Quantitative trait locus analysis of susceptibility to diet-induced atherosclerosis in recombinant inbred mice. Biochem. Genet. 32: 397-407.
28. Jacob, H. J., Lindpaintner, K., Lincoln, S. E., Kusumi, K., Bunker, R. K., Mao, Y. P., Ganten, D., Dzau, V. J. & Lander, E. S. (1991) Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. Cell 67: 213-224.
29. Jansen, R. C. (1994) Controlling the type I and type II errors in mapping quantitative trait loci. Genetics 138: 871-881.
30. Jansen, R. C. & Stam, P. (1994) High resolution of quantitative traits into multiple loci via interval mapping. Genetics 136: 1447-1455.
31. Jones, J. M., Meisler, M. H., Seldin, M. F., Lee, B. K. & Eicher, E. M. (1992) Localization of insulin-2 (Ins-2) and the obesity mutant tubby (tub) to distinct regions of mouse chromosome 7. Genomics 14: 197-199.
32. Katz, E. B., Stenbit, A. E., Hatton, K., DePinho, R. & Charron, M. J. (1995) Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4. Nature (Lond.) 377: 151-155.
33. Keightley, P. D., Hardge, T., May, L. & Bulfield, G. (1996) A genetic map of quantitative trait loci for body weight in the mouse. Genetics 142: 227-235.
34. Kleyn, P. W., Fan, W., Kovats, S. G., Lee, J. J., Pulido, J. C., Wu, Y., Berkemeier, L. R., Misumi, D. J., Holmgren, L., Charlat, O., Woolf, E. A., Tayber, O., Brody, T., Shu, P., Hawkins, F., Kennedy, B., Baldini, L., Ebeling, C., Alperin, G. D., Deeds, J., Lakey, N. D., Culpepper, J., Chen, H., Glucksmann-Kuis, M. A., Moore, K. J. (1996) Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family. Cell 85: 281-290.
35. Kopecky, J., Clarke, G., Enerback, S., Spiegelman, B. & Kozak, L. P. (1995) Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. J. Clin. Invest. 96: 2914-2923.
36. Kozak, L. P., Kozak, U. C. & Clarke, G. T. (1991) Abnormal brown and white fat development in transgenic mice overexpressing glycerol 3-phosphate dehydrogenase. Genes Dev. 5: 2256-2264.
37. Lander, E. S. & Botstein, D. (1989) Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121: 185-199.
38. Lander, E. S., Green, P., Abrahamson, J., Barlow, A., Daly, M. J., Lincoln, S. E. & Newburg, L. (1987) MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics 1: 74-181.
39. Lander, E. S. & Kruglyak, L. (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat. Genet. 11: 241-247.
40. Lander, E. S. & Schork, N. J. (1994) Genetic dissection of complex traits. Science (Washington, DC) 265: 2037-2048.
41. Lardinois, C. K., Caudill, T. & Starich, G. H. (1989) Dissimilar fatty acid composition of standard rat chow. Am. J. Med. Sci. 298: 305-308.
42. Leff, S. E., Brannan, C. I., Reed, M. L., Ozcelik, T., Francke, U., Copeland, N. G. & Jenkins, N. A. (1992) Maternal imprinting of the mouse Snrpn gene and conserved linkage homology with the human Prader-Willi syndrome region. Nat. Genet.2: 259-264.
43. Lembertas, A. V., Lusis, A. J. & Fisler, J. S. (1996a) Differential effects of leptin on growth and body weight in five mouse strains. Obes. Res. 4: 37S (abs.).
44. Lembertas, A. V., Lusis, A. J. & Fisler, J. S. (1996b) Differential effects of leptin on mass of four fat pads in five mouse strains. Obes.Res. 4: 37S (abs.).
45. Lembertas, A. V., Pérusse, L., Chagnon, Y. C., Fisler, J. S., Warden, C. H., Purcell-Huynh, D. A., Dionne, F. T., Gagnon, J., Nadeau, A., Lusis, A. J. & Bouchard, C. (1997) Identification of an obesity quantitative trait lows on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q. J. Clin. Invest. 100 (in press).
46. Luetteke, N. C., Lee, D. C., Palmiter, R. D., Brinster, R. L. & Sandgren, E. P. (1993) Regulation of fat and muscle development by transforming growth factor alpha in transgenic mice and in cultured cells. Cell Growth Dev. 4: 203-213.
47. Miller, M. W., Duhl, D. M. J., Vrieling, H., Cordes, S. P., Ollmann, M. M., Winkes, B. M. & Barsh, G. S. (1993) Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation. Genes Dev. 7: 454-467.
48. Moisan, M. P., Courvoisier, H., Bihoreau, M. T., Gauguier, D., Hendley, E. D., Lathrop, M., James, M. R. & Mormede, P. (1996) A major quantitative trait locus influences hyperactivity in the WKHA rat. Nat. Genet. 14: 471-473.
49. Morel, L., Yu, Y., Blenman, K. R., Caldwell, R. A. & Wakeland, E. K. (1996) Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain. Mammalian Genome 7: 335-339.
50. Nagase, H., Bryson, S., Fee, F. & Balmain, A. (1996) Multigenic control of skin tumour development in mice. Ciba Found. Symp. 197: 156-168.
51. Naggert, J. K., Fricker, L. D., Varlamov, O., Nishina, P. M., Rouille, Y., Steiner, D. F., Carroll, R. J., Paigen, B. J. & Letter, E. H. (1995) Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity. Nat. Genet. 10: 135-141.
52. Noben-Trauth, K., Naggert, J. K., North, M. A. & Nishina, P. M. (1996) A candidate gene for the mouse mutation tubby. Nature (Lond.) 380: 534-538.
53. Pace, M. J., Tieu. L., Warden, C. H. & Fisler, J. S. (1993) Differential response to ACTH stimulation in lean and obese mice in a model of polygenic obesity. Obes. Res. (Suppl. 1): 39S.
54. Paterson, A. H., Damon, S., Hewitt, J. D., Zamir, D., Rabinowitch, H. D., Lincoln, S. E., Lander, E. S. & Tanksley, S. D. (1991) Mendelian factors underlying quantitative traits in tomato: comparison across species, generations, and environments. Genetics 127:181-197.
55. Paterson, A. H., Lander, E. S., Hewitt, J. D., Peterson, S., Lincoln, S. E. & Tanksley, S. D. (1988) Resolution of quantitative traits into Mendelian factors by using a complete linkage map of restriction fragment length polymorphisms. Nature (Lond.) 335: 721-726.
56. Pepin, M.-C., Pothier, F. & Barden, N. (1992) Impaired type II glucocorticoid-receptor function in mice bearing antisense RNA transgene. Nature (Lond.) 355: 725-728.
57. Pomp, D., Cushman, M. A., Foster, S. C., Drudik, D. K., Fortman, M. & Eisen, E. J. (1994) Identification of quantitative trait loci for body weight and body fat in mice. In: 5th World Congress on Genetics Applied to Livestock Production, pp. 209-212. University of Guelph, Guelph, Canada.
58. Purcell-Huynh, D. A., Weinreb, A., Castellani, L. W., Mehrabian, M., Doolittle, M. K. & Lusis, A. J. (1995) Genetic factors in lipoprotein metabolism: analysis of a genetic cross between inbred mouse strains NZB/B1NJ and SM/J using a complete linkage map approach. J. Clin. Invest. 96: 1845-1858.
59. Ranee, K. A., Hastings, I. M., Hill, W. G. & Keightley, P. D. (1994) Mapping of putative QTL influencing body weight on the X chromosome in mice. In: 5th World Congress on Genetics Applied to Livestock Production, pp. 268-269. University of Guelph, Guelph, Canada.
60. Remmers, E. F., Longman, R. E., Du, Y., O'Hare, A., Cannon, G. W., Griffiths, M. M. & Wilder, R. L (1996) A genome scan localizes five non-MHC loci controlling collagen-induced arthritis in rats. Nat. Genet. 14: 82-85.
61. Samara, N. J., Gauguier, D., Vincent, M., Kaiser, M. A., Bihoreau, M. T., Lodwick, D., Wallis, R., Parent, V., Kimber, P., Rattray, F., Thompson, J. R., Sassard, J. & Lathrop, M. (1996) Analysis of quantitative trait loci for blood pressure on rat chromosomes 2 and 13. Age-related differences in effect. Hypertension 28: 1118-1122.
62. Schemmel, R., Mickelson, O. & Gill, J. L. (1970) Dietary obesity in rats: body weight and body fat accretion in seven strains of rats. J. Nutr. 100: 1041-1048.
63. Schork, N. J., Krieger, J. E., Trolliet, M. R., Franchini, K. G., Koike, G., Kreiger, E. M., Lander, E. S., Dzau, V. J. & Jacob, H. J. (1995) A biometrical genome search in rats reveals the multigenic basis of blood pressure variation. Genome Res. 5: 164-172.
64. Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., Muir, C., Sanker, S., Moriarty, A., Moore, K. J., Smutko, J. S., Mays, G. G., Woolf, E. A., Monroe, C. A. & Tepper, R. I. (1995) Identification and expression cloning of a leptin receptor, OB-R. Cell 83: 1263-1271.
65. Taylor, B. A. & Phillips, S. J. (1996) Detection of obesity QTLs on mouse chromosomes 1 and 7 by selective DNA pooling. Genomics 34: 389-398.
66. Tecott, L. H., Sun, L. M., Akana, S. F., Strack, A. M., Lowenstein, D. H., Dallman, M. F. & Julius, D. (1995) Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors. Nature (Lond.) 374: 542-546.
67. Warden, C. H. & Fisler, J. S. (1994) Identification of genes underlying polygenic obesity in animal models. In: The Genetics of Obesity (Boucnard, C., ed.), pp. 181-197. CRC Press, Boca Raton, FL
68. Warden, C. H. & Fisler, J. S. (1997) Molecular genetics of obesity. In: Handbook of Obesity (Bray, G. A., Bouchard, C. & James, W.P.T., eds.), CRC Press (in press).
69. Warden, C. H., Fisler, J. S., Pace, M. J., Svenson, K. L & Lusis, A. J. (1993) Coincidence of genetic loci for plasma cholesterol levels and obesity in a multifactorial mouse model. J. Clin. Invest. 92: 773-779.
70. Warden, C. H., Fisler, J. S., Shoemaker, S. M., Wen, P.-Z., Svenson, K. L., Pace, M. J. & Lusis, A. J. (1995) Identification of four chromosomal loci determining obesity in a multifactorial mouse model. J. Clin. Invest. 95: 1545-1552.
71. Warden, C. H., Kirchgessner, T., Lusis, A. J. & Fisler, J. S. (1996) Evidence that alleles of the leptin gene influence femoral fat pad weight in the BSB obesity model. Obes. Res. 4: 9S (abs.).
72. Warden, C. H., Mehrabian, M., He, K., Yoon, M.-Y., Diep, A., Xia, Y.-R., Wen, P.-Z., Svenson, K. L., Sparkes, R. S. & Lusis, A. J. (1993) Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics 18: 295-307.
73. West, D. B., Boozer, C. N., Moody, D. L. & Atkinson, R. L. (1992) Dietary obesity in nine inbred mouse strains. Am. J. Physiol. 262: R1025-R1032.
74. West, D. B., Goudey-Lefevre, J., York, B. & Truett, G. E. (1994a) Dietary obesity linked to genetic loci on chromosomes 9 and 15 in a polygenic mouse model. J.Clin.Invest. 94: 1410-1416.
75. West, D. B., Waguespack, J., York, B., Goudey-Lefevre, J. & Price, R. A. (1994b) Genetics of dietary obesity in AKR/J X SWR/J mice: segregation of the trait and identification of a linked locus on Chromosome 4. Mammalian Genome 5: 546-552.
76. York, B., Lei, K. & West, D. B. (1996) Sensitivity to dietary obesity linked to a locus on chromosome 15 in a CAST/Ei x C57BL/6J intercross. Mammalian Genome 7: 677-681.
77. Yui, M. A., Muralidharan, K., Moreno-Altamirano, B., Perrin, G., Chestnut, K. & Wakeland, E. K. (1996) Production of congenic mouse strains carrying NOD-derived diabetogenic genetic intervals: an approach for the genetic dissection of complex traits. Mammalian Genome 7: 331-334.
78. Zhang, Y., Proenca, R., Mattel, M., Barone, M., Leopold, L & Friedman, J. M. (1994) Positional cloning of the mouse obese gene and its human homologue. Nature (Lond.) 372: 425-432.