Major role for a 3p21 region and lack of involvement of the t(3;8) breakpoint region in the development of renal cell carcinoma suggested by loss of heterozygosity analysis

Genes Chromosomes and Cancer

Volumn 15, Issue 1, 1996, Pages 64-72

  Van Den Berg, Anke ^a   Hulsbeek, Miriam M F ^a   De Jong, Debora ^a   Kok, Klaas ^a   Veldhuis, Patrick M J F ^a   Roche, J ^b   Buys, Charles H C M ^a,c  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c Dept of Medical Genetics ^*  (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHROMOSOMAL LOCALIZATION; CHROMOSOME 3P; CHROMOSOME BREAKAGE; CLINICAL ARTICLE; CONTROLLED STUDY; GENE DELETION; GENE LOCATION; HETEROZYGOSITY; HUMAN; HUMAN CELL; KIDNEY CARCINOMA; PRIORITY JOURNAL;

CARCINOMA, RENAL CELL; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 3; CHROMOSOMES, HUMAN, PAIR 8; DNA, SATELLITE; HETEROZYGOTE; HUMANS; KIDNEY NEOPLASMS; TRANSLOCATION, GENETIC;

EID: 0030034627     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2264(199601)15:1<64::AID-GCC9>3.0.CO;2-2     Document Type: Article

References (33)

1. Boldog FL, Gemmill RM, Wilke CM, Glover TW, Nilsson AS, Chandrasekharappa SC, Brown RS, Li FP, Drabkin HA (1993) Positional cloning of the hereditary renal cell carcinoma 3;8 chromosome translocation breakpoint. Proc Natl Acad Sci U.S.A. 90: 8509-8513.
2. Choi PHK, Suen MWM, Huang DP, Lo K-W, Lee JCK (1993) Nasopharyngeal carcinoma: Genetic changes, Epstein-Barr virus infection, or both. A clinical and molecular study of 36 patients. Cancer 72:2873-2878.
3. Chung GTY, Huang DP, Lo KW, Chan MKM, Wong FWS (1992) Genetic lesions in the carcinogenesis of cervical cancer. Anticancer Res 12:1485-1490.
4. Cohen AJ, Li FP, Berg S, Marchetto DJ, Tsai S, Jacobs SC, Brown RS (1979) Hereditary renal cell carcinoma associated with a chromosomal translocation. N Engl J Med 13:592-595.
5. Daly MC, Xiang RH, Buchhagen D, Hensel CH, Garcia DK, Killary AM, Minna JD, Naylor SL (1993) A homozygous deletion on chromosome 3 in a small cell lung cancer line with a region of tumor suppressor activity. Oncogene 8:1825-1832.
6. Foster K, Crossey PA, Cairns P, Hetherington JW, Richards FM, Jones MH, Bentley E, Affara NA, Ferguson-Smith MA, Maher ER (1994a) Molecular genetic investigation of sporadic renal cell carcinoma: Analysis of allele loss on chromosomes 3p, 5q, 11p, 17 and 22. Br J Cancer 69:230-234.
7. Foster K, Prowse A, Van den Berg A, Fleming S, Hulsbeek MMF, Crossey PA, Richards FM, Cairns P, Affara NA, Ferguson-Smith MA, Buys CHCM, Maher ER (1994b) Somatic mutations of the Von Hippel Lindau disease tumour suppressor gene in nonfamilial clear cell renal carcinoma. Hum Mol Genet 3:2169-2173.
8. Gnarra JR, Tory K, Weng Y, Schmidt L, Wei MH, Li H, Latif F, Liu S, Chen F, Duh F-M, Lubensky I, Duan DR, Florence C, Pozzatti R, Walther MM, Bander NH, Grossman HB, Brauch H, Pomer S, Brooks JD, Isaacs WB, Lerman MI, Zbar B, Linehan WM (1994) Mutations of the VHL tumour suppressor gene in renal carcinoma. Nature Genet 7:85-90.
9. Jones MH, Nakamura Y (1992) Detection of loss of heterozygousity at the human TP53 locus using a dinucleotide repeat polymorphism. Genes Chromosom Cancer 5:89-90.
10. Killary AM, Wolf ME, Giambernardi TA, Naylor SL (1992) Definition of a tumor suppressor locus within human chromosome 3p21-p22. Proc Natl Acad Sci USA 89:10877-10881.
11. Kok K, Osinga J, Carritt B, Davis MB, Van der Hout AH, Van der Veen AY, Landsvater RM, de Ley LFMH, Berendsen HH, Postmus PE, Poppema S, Buys CHCM (1987) Deletion of a DNA sequence at the chromosomal region 3p21 in all major types of lung cancer. Nature 330:578-581.
12. Kok K, van den Berg A, Veldhuis PMJF, van der Veen AY, Franke M, Schoenmakers EFPM, Hulsbeek MMF, van der Hout AH, de Leij L, van der Ven W, Buys CHCM (1994) A homozygous deletion in a small cell lung cancer cell line involving a 3p21 region with a marked instability in YACs. Cancer Res 54:4183-4187.
13. Kok K, van den Berg A, Veldhuis PMJF, Franke M, Buys CHCM (1995) The genomic structure of the human UBE1L gene. Gene Expression 4:163-175.
14. Latif F, Tory K, Gnarra J, Yao M, Duh FM, Orcutt ML, Stackhouse T, Kuzmin I, Modi W, Geil L, Schmidt L, Zhou F, Li H, Wei MH, Chen F, Glenn G, Choyke P, Walther MM, Weng Y, Duan DSR, Dean M, Glavac D, Richards FM, Crossey PA, Ferguson-Smith MA, Le Paslier D, Chumakov I, Cohen D, Chinault C, Maher ER, Linehan WM, Zbar B, Lerman MI (1993) Identification of the von Hippel-Lindau disease tumor suppressor gene. Science 260:1317-1320.
15. Li FP, Decker HJH, Zbar B, Stanton VP, Kovacs G, Seizinger BR, Aburatani H, Sandberg AA, Berg S, Hosoe S, Brown RS (1993) Clinical and genetic studies of renal cell carcinomas in a family with a constitutional chromosome 3;8 translocation. Ann Intern Med 118:106-111.
16. Lubinski J, Hadaczek P, Podolski J, Toloczko A, Sikorski A, McCue P, Druck T, Huebner K (1994) Common regions of deletions in chromosome regions 3p12 and 3p14.2 in primary clear cell renal carcinomas. Cancer Res 54:3710-3713.
17. Maestro R, Gasparotto D, Vukosavljevic T, Barzan L, Sulfaro S, Boiocchi M (1993) Three discrete regions of deletion at 3p in head and neck cancers. Cancer Res 53:5775-5779.
18. Naylor SL, Sherman S, Drabkin HA, Whishenand E, Garcia D, Chinn R, DuBois B, Wilkie P, Weber JL, Nakamura Y (1992) A comprehensive genetic linkage map of the human genome [chromosome 3]. Science 258:67-86.
19. Naylor SL, Buys CHCM, Carritt B (1994) Report on the fourth international chromosome 3 workshop. Cytogenet Cell Genet 65: 1-32.
20. Rabbitts P, Bergh J, Douglas J, Collins F, Waters J (1990) A submicroscopic homozygous deletion at the D3S3 locus in a cell line isolated from a small cell lung carcinoma. Genes Chromosom Cancer 2:231-238.
21. Roche J, Whisenant E, Boldog F, Loeb D, Vance JM, Drabkin HA (1994) Dinucleotide repeats flanking the hereditary renal carcinoma t(3;8) breakpoint at 3p14.2. Hum Mol Genet 3:215.
22. Sanchez Y, El-Naggar A, Pathak S, Killary AM (1994) A tumor suppressor locus within human chromosome 3p14-p12 mediates rapid cell death of renal cell carcinoma in vivo. Proc Natl Acad Sci USA 91:3383-3387.
23. Shuin T, Kondo K, Torigoe S, Kishida T, Kubota Y, Hosaka M, Nagashima Y, Kitamura H, Latif F, Zbar B, Lerman MI, Yao M (1994) Frequent somatic mutations and loss of heterozygosity of the Von Hippel Lindau tumor suppressor gene in primary human renal cell carcinomas. Cancer Res 54:2852-2855.
24. Smith DI, Glover TW, Gemmill RM, Drabkin HA, O'Connell P, Naylor SL (1995) Report of the fifth international workshop on human chromosome 3 mapping 1994. Cytogenet Cell Genet 68: 125-146.
25. Takahasi E, Yamakawa K, Nakamura Y, Hori T (1992) A high resolution cytogenetic map of human chromosome 3: Localization of 291 new cosmid markers by direct R-banding fluorescence in situ hybridization. Genomics 13:1047-1055.
26. Thoenes W, Störkel S, Rumpelt HJ (1986) Histopathology and classification of renal-cell tumours (adenomas, oncocytomas and carcinomas). The basic cytological and histopathological elements and their use for diagnostics. Pathol Res Pract 181:125-143.
27. Todd S, Roche J, Hahner L, Bolin R, Drabkin HA, Gemmill RM (1995) YAC contigs covering an 8-megabase region of 3p deleted in the small-cell lung cancer cell line U2020. Genomics 25:19-28.
28. Van der Hout AH, Van der Vlies P, Wijmenga C, Li FP, Oosterhuis JW, Buys CHCM (1991) The region of common allelic losses in sporadic renal cell carcinoma is bordered by the loci D3S2 and THRB. Genomics 11:537-542.
29. van den Berg A, Kooy RF, Hulsbeek MMF, Jong de D, Kok K, Veen van dez AY, Buys CHCM: Ordering of polymorphic markers in the chromosome region 3p21. Cytogenet Cell Genet (in press).
30. Van der Hout AH, Berg vd E, Van der Vlies P, Dijkhuizen T, Störkel S, Oosterhuis JW, Buys CHCM (1993) Loss of heterozygosity at the short arm of chromosome 3 in renal cell cancer correlates with the cytological tumour type. Int J Cancer 53:353-357.
31. Yamakawa K, Morita R, Takahashi E, Hori T, Ishikawa J, Nakamura Y (1991) A detailed deletion mapping of the short arm of chromosome 3 in sporadic renal cell carcinoma. Cancer Res 51: 4707-4711.
32. Yokoyama S, Yamakawa K, Tsuchiya E, Murata M, Sekiyama S, Nakamura Y (1992) Deletion mapping on the short arm of chromosome 3 in squamous cell carcinoma and adenocarcinoma of the lung. Cancer Res 52:873-877.
33. Zbar B, Brauch H, Talmadge C, Linehan M (1987) Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma. Nature 327:721-724.