Quantitative image analysis of MIB-1 reactivity in inflammatory, hyperplastic, and neoplastic endocervical lesions

International Journal of Gynecological Pathology

Volumn 16, Issue 1, 1997, Pages 15-21

  Van Hoeven, K H ^a   Ramondetta, L ^a   Kovatich, A J ^a   Bibbo, Marluce ^a   Dunton, Charles J ^a  

^a THOMAS JEFFERSON UNIVERSITY HOSPITAL   (United States)

Author keywords

Endocervical adenocarcinoma; Endocervicitis; Immunohistochemistry; MIB 1; Microglandular hyperplasia

Indexed keywords

MONOCLONAL ANTIBODY KI 67;

ADULT; ARTICLE; CLINICAL ARTICLE; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; LABELING INDEX; PRIORITY JOURNAL; UTERINE CERVICITIS; UTERINE CERVIX CARCINOMA; UTERINE CERVIX HYPERTROPHY;

EID: 0030979266     PISSN: 02771691     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004347-199701000-00003     Document Type: Article

References (24)

1. Nichols TM, Fidler HK. Microglandular hyperplasia in cervical cone biopsies taken for suspicious and positive cytology. Am J Clin Pathol 1971;56:424-9.
2. Young RH, Clement PB. Pseudoneoplastic glandular lesions of the uterine cervix. Semin Diagn Pathol 1991;8:234-49.
3. Young RH, Scully RE. Atypical forms of microglandular hyperplasia of the cervix simulating carcinoma. Am J Surg Pathol 1989;13:50-6.
4. Gerdes J, Lemke H, Baisch H, Wacker HH, Schwab U, Stein H. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 1984;133:1710-5.
5. Cattoretti G, Becker MH, Key G, et al. Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB 1 and MIB 3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections. J Pathol 1992; 168:357-63.
6. Konishi I, Jujii S, Nonogaki H, Nanbu Y, Iwai T, Mon T. Immunohistochemical analysis of estrogen receptors, progesterone receptors, Ki-67 antigen, and human papillomavirus DNA in normal and neoplastic epithelium of the uterine cervix. Cancer 1991;68:1340-50.
7. Al-Saleh W, Delvenne P, Greimers R, Fridman V, Doyen J, Boniver J. Assessment of Ki-67 antigen immunostaining in squamous intraepithelial lesions of the uterine cervix. Correlation with the histologic grade and human papillomavirus type. Am J Clin Pathol 1995;104:154-60.
8. van Hoeven KH, Kovatich AJ. Immunohistochemical staining for proliferating cell nuclear antigen, BCL2, and Ki-67 in vulvar tissues Int J Gynecol Pathol 1996;15:10-6.
9. McCluggage WG, Maxwell P, McBride HA, Hamilton PW, Bharucha H. Monoclonal antibodies Ki-67 and MIB1 in the distinction of tuboendometrial metaplasia from endocervical adenocarcinoma and adenocarcinoma in situ in formalin-fixed material. Int J Gynecol Pathol 1995;14:209-16.
10. Tase T, Okagaki T, Clark BA, Twiggs LB, Ostrow RS, Faras AJ. HPV DNA in glandular dysplasia and microglandular hyperplasia: presumed precursors of adenocarcinoma of uterine cervix. Obstet Gynecol 1989;73:1005-8.
11. Higgins GD, Phillips GE, Smith LA, Uzelin DM, Burrell CJ. High prevalence of human papillomavirus transcripts in all grades of cervical intraepithelial glandular neoplasia. Cancer 1992;70:136-46.
12. Tase T, Okagaki T, Clark BA, Twiggs LB, Ostrow RS, Faras AJ. Human papillomavirus DNA in adenocarcinoma in situ, microinvasive adenocarcinoma of the uterine cervix, and coexisting cervical squamous intraepithelial neoplasia. Int J Gynecol Pathol 1989;8:8-17.
13. Hsu SM, Raine L, Fanger H. Use of avidin-biotin peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 1981;29:577-80.
14. Wilczynski SP, Walker J, Liao SY, Bergen S, Berman M. Adenocarcinoma of the cervix associated with human papillomavirus. Cancer 1988;62:1331-6.
15. Griffin NR, Dockey D, Lewis FA, Wells M. Demonstration of low frequency of human papillomavirus DNA in cervical adenocarcinoma and adenocarcinoma in situ by the polymerase chain reaction and in situ hybridization. Int J Gynecol Pathol 1991;10:36-43.
16. Milde-Langosch K, Schreiber C, Becker G, Loning T, Stegner HE. Human papillomavirus detection in cervical adenocarcinoma by polymerase chain reaction. Hum Pathol 1993; 24:590-4.
17. Duggan MA, Benoit JL, McGregor SE, Nation JG, Inoue M, Stuart GCE The human papillomavirus status of 144 endocervical adenocarcinoma cases by dot blot hybridization. Hum Pathol 1993;24:121-5.
18. Alejo M, Macedo I, Matias-Guiu X, Prat J. Adenocarcinoma in situ of the uterine cervix: clinicopathological study of nine cases with detection of human papillomavirus DNA by in situ hybridization and polymerase chain reaction. Int J Gynecol Pathol 1993;12:219-23.
19. Duggan MA, Benoit JL, McGregor E, Inoue M, Nation JG, Stuart CGE. Adenocarcinoma in situ of the endocervix: human papillomavirus determination by dot blot hybridization and polymerase chain reaction amplification. Int J Gynecol Pathol 1994;13:143-9.
20. van Hoeven KH, Kovatich AJ, Oliver RE, Nobel M, Dunton CJ. Protocol for immunocytochemical detection of SIL in cervical smears using MIB-1 antibody to Ki-67. Mod Pathol 1996;9:407-12.
21. Hendricks JB, Wilkinson EJ. Quality control considerations for Ki-67 detection and quantitation in paraffin-embedded tissue. J Cell Biochem [Suppl] 1994;19:105-10.
22. Kubbutat MHG, Key G, Duchrow M, Schluter C, Flad HD, Gerdes J. Epitope analysis of antibodies recognising the cell proliferation associated nuclear antigen previously defined by the antibody Ki-67 (Ki-67 protein). J Clin Pathol 1994; 47:524-8.
23. Schwarting R. Little missed markers and Ki-67. Lab Invest 1993;68:597-9.
24. Rose DSC, Maddox PH, Brown DC. Which proliferation markers for routine immunohistology? A comparison of five antibodies. J Clin Pathol 1994;47:1010-4.