Immunohistochemical staining for proliferating cell nuclear antigen, BCL2, and Ki-67 in vulvar tissues

International Journal of Gynecological Pathology

Volumn 15, Issue 1, 1996, Pages 10-16

  Van Hoeven, K H ^a   Kovatich, A J ^a  

^a THOMAS JEFFERSON UNIVERSITY HOSPITAL   (United States)

Author keywords

BCL2; Condyloma; Ki 67; PCNA; VIN; Vulva

Indexed keywords

CYCLINE; GENE PRODUCT; KI 67 ANTIGEN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY KI 67; TUMOR ANTIGEN;

ADULT; AGED; ARTICLE; BASAL CELL; CARCINOMA IN SITU; CLINICAL ARTICLE; CONDYLOMA; DYSPLASIA; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LICHEN SCLEROSUS ET ATROPHICUS; PRIORITY JOURNAL; PROTO ONCOGENE; VULVA CARCINOMA;

EID: 0030070385     PISSN: 02771691     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004347-199601000-00002     Document Type: Article

References (27)

1. Bravo R, Frank R, Blundell PA, Macdonald-Bravo H. Cyclin-PCNA is the auxiliary protein of DNA polymerase delta. Nature 1987;326:515-7.
2. Shurbaji MS, Brooks SK, Thurmond TS. Proliferating cell nuclear antigen. Immunoreactivity in cervical intraepithelial neoplasia and benign cervical epithelium. Am J Clin Pathol 1993;100:22-6.
3. Mittal KR, Demopoulos RI, Goswami S. Proliferating cell nuclear antigen (cyclin) expression in normal and abnormal cervical squamous epithelia. Am J Surg Pathol 1993;17:117-22.
4. Konishi I, Jujii S, Nonogaki H, Nanbu Y, Iwai T, Mori T. Immunohistochemical analysis of estrogen receptors, progesterone receptors, Ki-67 antigen, and human papillomavirus DNA in normal and neoplastic epithelium of the uterine cervix. Cancer 1991;68:1340-50.
5. Devictor B, Bonnier P, Piana L, et al. c-myc protein and Ki-67 antigen immunodetection in patients with uterine cervix neoplasia: correlation of microcytophotometric analysis with histological data. Gynecol Oncol 1993;49:284-90.
6. Freidrich EG. Julian CG, Woodruff JD. Acridine orange fluorescence in vulvar dysplasia. Am J Obstet Gynecol 1964; 90:1281-7.
7. Woodruff JD, Borkowf HI, Holzman GB, Arnold EA, Knaack J. Metabolic activity in normal and abnormal vulvar epithelia. An assessment by the use of initiated nucleic acid precursors. Am J Obstet Gynecol 1965;91:809-16.
8. Hockenbery DM, Oltvai ZN, Yin XM, Milliman CL, Korsmeyer SJ. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 1993;75:241-51.
9. Hockenbery DM, Zutter M, Hickey W, Nahm M, Korsmeyer SJ. BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci 1991;88:6961-5.
10. Hsu SM, Raine L, Fanger H. Use of avidin-biotin peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 1981;29:577-80.
11. Cattoretti G, Becker MH, Key G, et al. Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB 1 and MIB 3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections. J Pathol 1992; 168:357-63.
12. Login GR, Dvorak AM. Methods of microwave fixation for microscopy. A review of research and clinical applications: 1970-1992. Prog Histochem Cytochem 1994;27:1-127.
13. Slitonen SM, Kallioniemi OP, Isola JJ. Proliferating cell nuclear antigen immunohistochemistry using monoclonal antibody 19A2 and a new antigen retrieval technique has prognostic impact in archival paraffin-embedded node-negative breast cancer. Am J Pathol 1993;142:1081-9.
14. Murakami T, Nagai N, Ota S, Ohama K. Comparative study of HPV infection and proliferating cell nuclear antigen of uterine cervix. Acta Obst Gynaecol Jpn 1993;45:967-72.
15. Raju GC. Expression of the proliferating cell nuclear antigen in cervical neoplasia. Int J Gynecol Pathol 1994;13:337-41.
16. Tuccari G, Rizzo A, Muscara M, Giuffre G, Barresi G. PCNA/cyclin expression in breast carcinomas: its relation- ships with Ki-67, ER, PgR immunostainings and clinicopathologic aspects. Pathologica 1993;85:47-55.
17. McCormick D, Hall PA. The complexities of proliferating cell nuclear antigen. Histopathology 1992;21:591-4.
18. Scott RJ, Hall PA, Haldane JS, et al. A comparison of immunohistochemical markers of cell proliferation with experimentally determined growth fractions. J Pathol 1991;165: 173-8.
19. Schwarting R. Little missed markers and Ki-67. Lab Invest 1993;68:597-9.
20. van Hoeven KH, Randleman GA, Artymyshyn RL. Cytologic findings in lichen sclerosus. Acta Cytol (in press).
21. Punnonen R, Soidinmaki H, Kauppila O, Pystynen P. Relationship of vulvar lichen sclerosus et atrophicus to carcinoma. Ann Chir Gynaecol Suppl 1985;197:23-5.
22. Newton JA, Camplejohn RS, McGibbon DH. A flow cytometric study of the significance of DNA aneuploidy in cutaneous lesions. Br J Dermatol 1987;117:169-74.
23. Kiene P, Milde-Langosch K, Loning T. Human papilloma-virus infection in vulvar lesions of lichen sclerosus et atrophicus. Arch Derm Res 1991;283:445-8.
24. Martinez de Oliveira J, Saleiro V. Involucrin expression in vulvar lesions. J Reprod Med 1986;31:828-30.
25. Miyagawa S, Okada N, Takasaki Y, et al. Expression of proliferating cell nuclear antigen/cyclin in human keratinocytes. J Invest Dermatol 1989;93:678-81.
26. Tsujimoto Y, Cossman J, Jaffe E, Croce CM. Involvement of the bcl-2 gene in human follicular lymphoma. Science 1985;228:1440-3.
27. Silvestrini R, Veneroni S, Grazia Daidone M, et al. The Bcl-2 protein: a prognostic indicator strongly related to p53 protein in lymph node-negative breast cancer patients. J Natl Cancer Inst 1994;86:499-504.