An equine herpesvirus-1 gene 71 deletant is attenuated and elicits a protective immune response in mice

Virology

Volumn 231, Issue 1, 1997, Pages 20-27

  Marshall, Ker R ^c   Sun, Yi ^c   Brown, S Moira ^b   Field, Hugh J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c INSTITUTE OF VIROLOGY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HERPES VACCINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DELETION MUTANT; FEMALE; HERPES SIMPLEX VIRUS 1; HORSE; IMMUNE RESPONSE; IMMUNIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; VIRUS MUTANT; VIRUS PATHOGENESIS;

ANIMALIA; EQUIDAE; EQUINE HERPESVIRUS 1; EQUUS CABALLUS; ESCHERICHIA COLI; HERPES; HERPESVIRIDAE; HERPESVIRUS 1; HUMAN HERPESVIRUS 1; MIRIDAE; SIMIAE; SIMIAN VIRUS; SIMIAN VIRUS 40;

EID: 0030977372     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1997.8483     Document Type: Article

References (39)

1. Allen G. P., Bryans J. T. Molecular epizootiology, pathogenesis and prophyllaxis of equine herpesvirus-1 infections. Prog. Vet. Microbiol. Immunol. 2:1986;78-144.
2. Audonnet J-C., Winslow J., Allen G., Paoletti. Equine herpesvirus type 1 unique short fragment encodes glycoproteins with homology to herpes simplex virus type 1 gD, gI and gE. J. Gen. Virol. 71:1990;2969-2978.
3. Awan A. R., Chong Y-C., Field H. J. The pathogenesis of equine herpesvirus type 1 in the mouse: A new model for studying host responses to the infection. J. Gen. Virol. 71:1990;1131-1140.
4. Awan A. R., Gibson J. S., Field H. J. A murine model for studying EHV-1 induced abortion. Res. Vet. Sci. 51:1991;94-99.
5. Azmi M., Field H. J. Cell-mediated antiviral response to equine herpesvirus type 1 demonstrated in a murine infection model by means of adoptive transfer of immune cells. J. Gen. Virol. 74:1993a;275-280.
6. Azmi M., Field H. J. Interactions between equine herpesvirus type 1 and equine herpesvirus type 4: T cell responses in a murine infection model. J. Gen. Virol. 74:1993b;2339-2345.
7. Balan P., Davis-Poynter N., Bell S., Atkinson H., Browne H., Minson A. An analysis of thein vitroin vivo. J. Gen. Virol. 75:1994;1245-1258.
8. Baumeister J., Klupp B. G., Mettenleiter T. C. Pseudorabies virus and equine herpesvirus type 1 which is absent in other herpesviruses and located adjacent to a highly conserved gene cluster. J. Virol. 69:1995;5560-5567.
9. Baxi M. K., Borchers K., Bartels T., Schellenbach A., Baxi S., Field H. J. Molecular studies of the acute infection, latency and reactivation of equine herpesvirus-1 (EHV-1) in the mouse model. Virus Res. 40:1996;33-45.
10. Breeden C. A., Yalamanchili R. R., Colle C. F., O'Callaghan D. J. Identification and transcriptional mapping of genes encoded at the IR/Us junction of equine herpesvirus type 1. Virology. 191:1992;649-660.
11. Brunovskis P., Velicer L. F. The Marek's disease virus (MDV) unique short region: Alphaherpesvirus-homologous, fowlpox virus-homologous and MDV-specific genes. Virology. 206:1995;324-338.
12. Bryans J. T., Allen G. P. Herpesviral diseases of the horse. Herpesvirus Diseases of Cattle, Horse and Pig. 1989;Kluwer Academic, Boston. p. 176-229.
13. Campbell T. M., Studdert M. J. Equine herpesvirus type-1 (EHV-1). Vet. Bull. 53:1983;135-146.
14. Christofinis G. J., Beale A. J. Some biological characters of cell lines derived from normal rabbit kidney. J. Pathol. Bacteriol. 95:1968;377-381.
15. Colle C. F., Flowers C. C., O'Callaghan D. J. Open reading frames encoding a protein kinase, homologue of glycoprotein gX of pseudorabies virus, and a novel glycoprotein map within the unique short segment of equine herpesvirus type 1. Virology. 188:1992;545-557.
16. Colle C. F., Tarbet E. B., Grafton W. D., Jennings S. R., O'Callaghan D. J. Equine herpesvirus-1 strain KyA, a candidate vaccine strain, reduces viral titers in mice challenged with a pathogenic strain, RacL. Virus Res. 43:1996;111-124.
17. Cullinane A. A., Rixon F. J., Davison A. J. Characterization of the genome of equine herpesvirus 1 subtype 2. J. Gen. Virol. 69:1988;1575-1590.
18. Davison A. J., Wilkie N. M. Location and orientation of homologous sequences in the genomes of five herpesviruses. J. Gen. Virol. 64:1983;1927-1942.
19. Dingwell K. S., Doering L. C., Johnson D. C. Glycoproteins E and I facilitate neuron-to-neuron spread of herpes simplex virus. J. Virol. 69:1995;7087-7098.
20. Elton D. M., Halliburton I. W., Killington R. A., Meredith D. M., Bonass W. A. Sequence analysis of the 4.7-kbBamEco. Gene. 101:1991;203-208.
21. Georgopoulou U., Michealidou A., Roizman B., Mavromara-Nazos P. Identification of a new transcriptional unit that yields a gene product within the unique sequences of the short component of the herpes simplex virus 1 genome. J. Virol. 67:1993;3961-3968.
22. Kimman T. G., de Wind N., Oei-Lie N., Pol J. M. A., Berns A. J. M., Gielkens A. L. J. Contribution of single genes within the unique short region of Aujeszky's disease virus (suid herpesvirus type 1) to virulence, pathogenesis and immunogenicity. J. Gen. Virol. 73:1992;243-251.
23. Leung-Tack P., Audonnet J. C., Riviere J. The complete DNA sequence and the genetic organisation of the short unique region (Us) of the bovine herpesvirus type 1 (ST strain). Virology. 199:1994;409-421.
24. Matsumura T., O'Callaghan D. J., Kondo T., Kamada M. Lack of virulence of the murine fibroblast adapted strain, Kentucky A (KyA), of equine herpesvirus type 1 (EHV-1) in young horses. Vet. Microbiol. 48:1996;353-365.
25. McGeoch D. J., Barnett B. C., MacLean C. A. Emerging functions of alphaherpesvirus genes. Semin. Virol. 4:1993;125-134.
26. McGeoch D. J., Dolan A., Donald S., Rixon F. J. Sequence determination and genetic content of the short unique region in herpes simplex virus type 1. J. Mol. Virol. 181:1985;1-13.
27. McGeoch D. J., Moss H. W. M., McNab D, Frame M. C. DNA sequence and genetic content of the HindIII l region in the short unique component of the herpes simplex virus type 2 genome: Identification of the gene encoding gG and evolutionary comparisons. J. Gen. Virol. 68:1987;19-38.
28. Nagesha H. S., Crabb B. S., Studdert M. J. Analysis of the nucleotide sequence of five genes at the left end of the unique short region of the equine herpesvirus 4 genome. Arch. Virol. 128:1993;143-154.
29. Osterrieder N., Wagner R., Brandmuller C., Schmidt P., Wolf H., Kaaden O-R. Protection against EHV-1 challenge infection in the murine model after vaccination with various formulations of recombinant glycoprotein gp 14 (gB). Virology. 208:1995;500-510.
30. Roizman B., Desrosiers R. C., Fleckenstein B., Lopez C., Minson A. C., Studdert M. J. The family herpesviridae: An update. Arch. Virol. 123:1992;425-449.
31. Slater J. D., Gibson J. S., Field H. J. Pathogenicity of a thymidine kinase-deficient mutant of equine herpesvirus 1 in mice and specific pathogen-free foals. J. Gen. Virol. 74:1993;819-828.
32. Stow N. D., Wilkie N. M. An improved technique for obtaining enhanced infectivity with herpes simplex virus type 1 DNA. J. Gen. Virol. 33:1976;447-458.
33. Sun Y., Brown S. M. The open reading frames 1, 2, 71 and 75 are non-essential for the replication of equine herpesvirus type 1in vitro. Virology. 199:1994;448-452.
34. Sun Y., MacLean A. R., Aitken J. D., Brown S. M. The role of the gene 71 product in the life cycle of equine herpesvirus 1. J. Gen. Virol. 77:1996;493-500.
35. Sun Y., MacLean A. R., Brown S. M. Identification and characterization of the protein product of gene 67 in equine herpesvirus type 1 strain Ab4. J. Gen. Virol. 76:1995;541-550.
36. Sun Y., MacLean A. R., Dargan D., Brown S. M. Identification and characterization of the protein product of gene 71 in equine herpesvirus 1. J. Gen. Virol. 75:1994;3117-3126.
37. Telford E. A. R., Watson M. S., McBride K., Davison A. J. The DNA sequence of equine herpesvirus-1. Virology. 189:1992;304-316.
38. Tewari D., Whalley J. M., Love D. N., Field H. J. Characterization of immune responses to baculovirus expressed equine herpesvirus 1 glycoprotein D and H in a murine model. J. Gen. Virol. 75:1994;1735-1741.
39. Willemse M. J., Strijdveen I. G. L., Van Schooneveld S. H. B., Van Den Berg M. C., Sondermeijer P. J. A. Transcriptional analysis of the short segment of the feline herpesvirus type 1 genome and insertional mutagenesis of a unique reading frame. Virology. 208:1995;704-711.