Pituitary-directed leukemia inhibitory factor transgene forms Rathke's cleft cysts and impairs adult pituitary function: A model for human pituitary Rathke's cysts

Journal of Clinical Investigation

Volumn 99, Issue 10, 1997, Pages 2462-2469

  Akita, Sadanori ^a   Readhead, Carol ^a   Stefaneanu, Lucia ^b   Fine, Jeremy ^a   Tampanaru Sarmesiu, Alina ^b   Kovacs, Kalman ^b   Melmed, Shlomo ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b ST MICHAEL'S HOSPITAL   (Canada)

^c CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

leukemia inhibitory factor; pituitary development; Rathke's cyst; transgenic model

Indexed keywords

CORTICOTROPIN; GROWTH HORMONE; LEUKEMIA INHIBITORY FACTOR; LUTEINIZING HORMONE; PROLACTIN; RECEPTOR PROTEIN; THYROTROPIN;

ADENOHYPOPHYSIS; ANIMAL TISSUE; ARTICLE; CELL DIVISION; CONTROLLED STUDY; CYST; GROWTH HORMONE DEFICIENCY; HUMAN; HUMAN TISSUE; MOUSE; NONHUMAN; ORGANOGENESIS; PRIORITY JOURNAL; RATHKE CLEFT CYST; SHORT STATURE; TRANSGENE;

EID: 0030976948     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119430     Document Type: Article

References (30)

1. Patterson, P.H. 1994. Leukemia inhibitory factor, a cytokine at the interface between neurology and immunology. Proc. Natl. Acad. Sci. USA. 91:7833-7835.
2. Gearing, O.P., I.A. King, and N.M. Gough. 1988. Complete sequence of murine myeloid leukemia inhibitory factor (LIF). Nucleic Acids Res. 16:9857.
3. Shen, M.M., and P. Leder. 1992. Leukemia inhibitory factor is expressed by the preimplantation uterus and selectively blocks primitive ectoderm formation in vitro. Proc. Natl. Acad. Sci. USA. 89:8240-8244.
4. Stewart, C.L., P. Kasper, L.J. Brunei, H. Bhatt, F. Konkgen, and S. J. Abbandanzo. 1992. Blastocyst implantation depends on maternal expression of leukemia inhibitory factor. Nature (Lond). 359:76-79.
5. Bamber, B.A., B.A. Maters, G.W. Hoyle, R.L. Brinster, and R.D. Palmiter. 1994. Leukemia inhibitory factor induces neurotransmitter switching in transgenic mice. Proc. Natl. Acad. Sci. USA. 91:7839-7843.
6. Shen, M.M., R.C. Skoda, R.D. Cardiff, J. Campos-Torres, P. Leder, and D.M. Ornitz. 1994. Expression of LIF in transgenic mice results in altered thymic epithelium and apparent interconversion of thymic and lymph node morphologies. EMBO (Eur. Mol. Biol. Organ.) J. 13:1375-1385.
7. Metcalf, D., and D.P. Gearing. 1989. Fetal syndrome in mice engrafted with cells producing high levels of the leukemia inhibitory factor. Proc. Natl. Acad. Sci. USA. 86:5948-5952.
8. Block, M.L, D.L. Fraker, G. Strassmann, K.G. Billingsley, W.S. Arnold, C. Perlis, and H.R. Alexander. 1993. Passive immunization of mice against D factor blocks lethality and cytokine release during endotoxemia. J. Exp. Med. 178:1085-1090.
9. Akita, S., J. Webster, S.O. Ren, H. Takino, J. Said, O. Zand, and S. Melmed. 1995. Human and murine pituitary expression of leukemia inhibitory factor-novel intrapituitary regulation of adrenocorticotropin hormone synthesis and secretion. J. Clin. Invest. 95:1288-1298.
10. Ray, D.W., S.G. Ren, and S. Melmed. 1996. Leukemia inhibitory factor (LIF) stimulates proopiomelanocortin (POMC) expression in a corticotroph cell line: role of stat pathway. J. Clin. Invest. 97:1852-1859.
11. Stefana, B., D.W. Ray, and S. Melmed. 1996. Leukemia inhibitory factor (LIF) induces differentiation of pituitary corticotroph function: a neuro-endocrine phenotypic switch. Proc. Natl. Acad. Sci. USA. 93:12502-12506.
12. Wang, Z., S.G. Ren, and S. Melmed. 1996. Hypothalamic and pituitary leukemia inhibitory factor gene expression in vivo: a novel endotoxin-inducible neuro-endocrine interface. Endocrinology. 137:2947-2953.
13. Akita, S., J. Malkin, and S. Melmed. 1996. Disrupted murine leukemia inhibitory factor (LIF) gene attenuates adrenocorticotropic hormone (ACTH) secretion. Endocrinology. 137:3140-3143.
14. Rugh, R. 1990. Organogeny in the mouse: its reproduction and development. R. Rugh, ed. Oxford Univ. Press, New York. 259-261.
15. Miller, W., and N.L. Eberhardt. 1983. Structure and evolution of the growth hormone gene family. Endocr. Rev. 4:97-130.
16. Hogan, B., R. Beddington, F. Costantini, and E. Lacy. 1994. Manipulating the mouse embryo. 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York. 219-252.
17. Lloyd, R.V., L. Lin, W.F. Chandler, E. Hovath, L. Stefaneanu, and K. Kovacs. 1993. Pituitary specific transcription factor messenger ribonucleic expression in adenomatous and nontumorous human pituitary tissues. Lab. Invest. 69:570-575.
18. Simmons, D.M., J.W. Voss, H.A. Ingraham, J.M. Holloway, R.S. Broide, M.G. Rosenfeld, and L.W. Swanson. 1990. Pituitary cell phenotypes involve cell-specific Pit-1 mRNA translation and synergic interactions with other classes of transcription factors. Genes Dev. 4:695-711.
19. Ikeda, H., and T. Yoshimoto. 1991. Developmental changes in proliferative activity of cells of the murine Rathke's pouch. Cell Tissue Res. 263:41-47.
20. Scheithauer, B.W. 1985. Pathology of the pituitary and sellar region: exclusive of pituitary adenoma. Ann. Pathol. 20:67-154.
21. Ikeda, H., J. Suzuki, N. Sasano, and H. Niizuma. 1988. The development and morphogenesis of the human pituitary gland. Anal. Embryol. 178:327-336.
22. Ross, D.A., D. Norman, and C.B. Wilson. 1992. Radiologie characteristics and results of surgical management of Rathke's cysts in 43 patients. Neurosnrgery. 30:173-179.
23. Mindermann, T., and C.B. Wilson. 1995. Pediatric pituitary adenomas. Neurosurgery. 36:259-269.
24. Mukherjee, J.J., N. Islam, G. Kaltsas, D. Lowe, M. Charlesworth, F. Afshar, P.J. Trainer, J.P. Munson, G. Besser, and A.B. Grossman. 1996. Rathke's cleft cyst: not such a benign lesion. J. Endocrinol. 151(Suppl. 014).
25. Borelli, E., R.A. Heyman, C. Arias, P.E. Sawchenko, and R.M. Evans. 1989. Transgenic mice with inducible dwarfism. Nature (Lond.). 339:538-541.
26. Behringer, R.R., L.S. Mathews, R.D. Palmiter, and R.L. Brinster. 1988. Dwarf mice produced by genetic ablation of growth hormone-expressing cells. Genes Dev. 1:453-461.
27. Struthers, R.S., W.W. Vale, C. Arias, P.E. Sawchenko, and M.R. Monttniny. 1991. Somatotroph hypoplasia and dwarfism in transgenic mice expressing a non-phosphorylatable CREB mutant. Nature (Lond.). 350:622-624.
28. Bertherat, J., P. Chanson, and M. Montminy. 1995. The cyclic adenosine 3′, 5′-monophosphate-responsive factor CREB is constitutively activated in human somatotroph adenomas. Mol. Endocrinol. 9:777-783.
29. Voss, J.W., and M.G. Rosenfeld. 1992. Anterior pituitary development: short tales from dwarf mice. Cell 70:527-530.
30. Hermesz, E., S. Mackem, and K.A. Mahon. 1996. Rpx: a novel anterior-restricted homeobox gene progressively activated in the prechordal plate, anterior neural plate and Rathke's pouch of the mouse embryo. Development (Camb.). 122:41-52.