Ventromedial hypothalamic lesions impair glucoregulation in response to endotoxin

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 272, Issue 5 41-5, 1997, Pages

  Lynch, John P ^a   Wojnar, Margaret M ^a   Lang, Charles H ^a,b  

^a STONY BROOK UNIVERSITY   (United States)

^b PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

Epinephrine; Glucagon; Gluconeogenesis; Glucose utilization; Glycogen; Hepatic glucose production; Hyperglycemia; Tumor necrosis factor; Ventromedial hypothalamus

Indexed keywords

ESCHERICHIA COLI LIPOPOLYSACCHARIDE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GLUCAGON BLOOD LEVEL; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030976639     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1997.272.5.r1525     Document Type: Article

References (19)

1. Barton, R. N., and B. J. Passingham. Evidence for a role of glucocorticoids in the development of insulin resistance after ischaemic limb injury in the rat. J. Endocrinol. 86: 363-370, 1980.
2. Borg, W. P., M. J. Buring, R. S. Sherwin, M. A. Borg, M. L. Brines, and G. I. Shulman. Ventromedial hypothalamic lesions in rats suppress counterregulatory responses to hypoglycemia. J. Clin. Invest. 93: 1677-1682, 1994.
3. Coyle, J. T., M. E. Molliver, and M. J. Kuhar. In situ injection of kainic acid: a new method for selectively lesioning neuronal cell bodies while sparing axons of passage. J. Comp. Neurol. 180: 301-324, 1978.
4. Fan, J., Y. H. Li, M. M. Wojnar, and C. H. Lang. Endotoxin-induced alterations in insulin-stimulated phosphorylation of insulin receptor, IRS-1, and MAP kinase in skeletal muscle. Shock 6: 164-170, 1996.
5. Hare, A. S., G. Clarke, and S. Tolchard. Bacterial lipopolysaccharide-induced changes in FOS protein expression in the rats brain: correlation with thermoregulatory changes and plasma corticosterone. J. Neuroendocrinol. 7: 791-799, 1995.
6. Hargrove, D. M., G. J. Bagby, C. H. Lang, and J. J. Spitzer. Adrenergic blockade prevents endotoxin-induced increases in glucose metabolism. Am. J. Physiol. 255 (Endocrinol. Metab. 18): E629-E635, 1988.
7. Hargrove, D. M., C. H. Lang, G. J. Bagby, and J. J. Spitzer. Epinephrine-induced increase in glucose turnover is diminished during sepsis. Metabolism 38: 1070-1076, 1989.
8. Jones, S. B., and F. D. Romano. Dose- and time-dependent changes in plasma catecholamines in response to endotoxin in conscious rats. Circ. Shock 28: 59-68, 1989.
9. Keepler, D., and K. Decker. Glycogen determination with amyloglucosidase. In: Methods of Enzymatic Analysis, edited by H. U. Bergmeyer. New York: Academic, 1974, p. 1127-1131.
10. King, B. M., R. L. Smith, and L. A. Frohman. Hyperinsulinemia in rats with ventromedial hypothalamic lesions: role of hyperphagia. Behav. Neurosci. 98: 152-155, 1984.
11. Lang, C. H. Sepsis-induced insulin resistance in rats is mediated by a β-adrenergic mechanism. Am. J. Physiol. 262 (Endocrinol. Metab. 25): E703-E711, 1992.
12. Lang, C. H. β-Adrenergic blockade attenuates insulin resistance induced by tumor necrosis factor. Am. J. Physiol. 264 (Regulatory Integrative Comp. Physiol. 33): R984-R991, 1993.
13. Lang, C. H. Neural regulation of the enhanced uptake of glucose in skeletal muscle after endotoxin. Am. J. Physiol. 269 (Regulatory Integrative Comp. Physiol. 38): R437-R444, 1995.
14. Lang, C. H., G. J. Bagby, H. L. Blakesley, and J. J. Spitzer. Importance of hyperglucagonemia in eliciting the sepsis-induced hyperglycemia. Circ. Shock 29: 181-192, 1989.
15. Lang, C. H., G. J. Bagby, and J. J. Spitzer. Glucose kinetics following lethal and sublethal doses of endotoxin. Am. J. Physiol. 248 (Regulatory Integrative Comp. Physiol. 17): R471-R478, 1985.
16. Lavicky, J., and A. J. Dunn. Endotoxin administration stimulates cerebral catecholamine release in freely moving rats as assessed by microdialysis. J. Neurosci. Res. 40: 407-413, 1995.
17. Levin, B. E., S. Stoddard-Apter, and A. C. Sullivan. Central activation and peripheral function of sympatho-adrenal and cardiovascular systems in the Zucker rat. Physiol. Behav. 32: 295-299, 1984.
18. Luiten, P. G., G. J. Ter Horst, and A. B. Steffens. The hypothalamus, intrinsic connections and outflow pathways to the endocrine system in relation to the control of feeding and metabolism. Prog. Neurobiol. 28: 1-54, 1987.
19. Matsui, M., H. Ishibashi, K. Kimura, M. Shiota, M. Ohta, and T. Sugano. Responses to catecholamines in perfused livers of hypothalamic-lesioned rats. Am. J. Physiol. 265 (Regulatory Integrative Comp. Physiol. 34): R117-R123, 1993.