Libraries of angiotensin converting enzyme inhibitors: Solid-phase synthesis and affinity selection

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 7, 1997, Pages 823-826

  Blackburn, Christopher ^a   Pingali, Aruna ^a   Kehoe, Terry ^a   Herman, Lee W ^a   Wang, Hongqi ^a   Kates, Steven A ^a  

^a PERKINELMER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; ENALAPRILAT;

ARTICLE; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ENZYME BINDING; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MASS SPECTROMETRY; METHODOLOGY; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

EID: 0030975349     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00112-1     Document Type: Article

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37. 2O/0.1% TFA from 0:1 to 1:0, flow rate 1.0 mL/min) dissociated the noncovalently bound ligands from the enzyme and the eluted fractions were analyzed by a ESI-MS.
38. 340nm due to hydrolysis of the FAPGG substrate in the presence and absence of the dipeptides.