RU486 on an Estrogen Background Blocks the Rise in Serum Follicle-Stimulating Hormone Induced by Antiserum to Inhibin or Ovariectomy

Endocrinology

Volumn 137, Issue 4, 1996, Pages 1226-1232

  Knox, Kerry L ^a   Ringstrom, Sonia J ^a   Szabo, Marta ^a   Perlyn, Chad A ^a   Sutandi, Sara ^a   Schwartz, Neena B ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN; FOLLITROPIN; INHIBIN; MIFEPRISTONE; PROGESTERONE RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ESTRADIOL BLOOD LEVEL; ESTRUS CYCLE; FEMALE; FOLLITROPIN BLOOD LEVEL; FOLLITROPIN RELEASE; NONHUMAN; ORAL CONTRACEPTION; OVARIECTOMY; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; BODY FLUIDS; ESTRADIOL; ESTRUS; FEMALE; FOLLICLE STIMULATING HORMONE; GONADOTROPINS; HORMONE ANTAGONISTS; IMMUNE SERA; INHIBINS; METESTRUS; MIFEPRISTONE; OVARIECTOMY; PROESTRUS; PROGESTERONE; RATS; RATS, SPRAGUE-DAWLEY; UTERUS;

EID: 0029918629     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.137.4.8625893     Document Type: Article

References (48)

1. Smith MS, Freeman ME, Neill JD 1975 The control of progesterone secretion during the estrous cycle and early pseudopregnancy in the rat: prolactin, gonadotropin and steroid levels associated with rescue of the corpus luteum of pseudopregnancy. Endocrinology 96: 219-226
2. Knox KL, Ringstrom SJ, Schwartz NB 1993 RU486 blocks the effects of inhibin antiserum or luteinizing hormone on the secondary follicle-stimulating hormone surge. Endocrinology 133:277-283
3. Knox KL, Schwartz NB 1992 RU486 blocks the secondary surge of follicle-stimulating hormone in the rat without blocking the drop in serum inhibin. Biol Reprod 46:220-225
4. Szabo M, Knox KL, Ringstrom SJ, Perlyn CA, Sutandi S, Schwartz NB 1996 Mechanism of the inhibitory action of RU486 on the secondary follicle-stimulating hormone surge. Endocrinology 137: 85-89
5. Caligaris L, Astrada JJ, Taleisnik S 1968 Stimulating and inhibiting effects of progesterone on the release of luteinizing hormone. Acta Endocrinol (Copenh) 59:177-185
6. Beattie CW, Schwartz NB 1973 Blockade of the proestrous LH surge in cyclic rats by barbiturate administration on diestrus. Proc Soc Exp Biol Med 142:933-935
7. Banks JA, Freeman ME 1978 The temporal requirement of progesterone on proestrus for extinction of the estrogen-induced daily signal controlling luteinizing hormone release in the rat. Endocrinology 102:426-432
8. Mahesh VB, Muldoon TG 1987 Integration of the effects of estradiol and progesterone in the modulation of gonadotropin secretion. J Steroid Biochem 27:665-675
9. Rivier C, Vale W 1989 Immunoneutralization of endogenous inhibin modifies hormone secretion and ovulation rate in the rat. Endocrinology 125:152-157
10. McAndrews JM, Ringstrom SJ, Dahl KD, Schwartz NB 1993 Effects of corticosterone and testosterone on pituitary gonadotropin content, secretion, bioactivity, and messenger RNA levels in the presence or absence of GnRH in male rats. Endocr J 3:13-20
11. Aloi JA, Dalkin AC, Schwartz NB, Yasin M, Mann B, Haisenleder DJ, Marshall JC 1995 Ovarian inhibin subunit gene expression: regulation by gonadotropins and estradiol. Endocrinology 136:1227-1232
12. Tébar M, Bellido C, Sánchez-Criado JE 1995 Luteinizing hormone (LH) and corticosterone in proestrous afternoon restore the follicle- stimulating hormone secretion at early estrus in adrenalectomized LH-releasing hormone antagonist-treated rats. Biol Reprod 52:63-67
13. Ackland JF, D'Agostino J, Ringstrom SJ, Hostetler JP, Mann BG, Schwartz NB 1990 Circulating radioimmunoassayable inhibin during periods of transient follicle-stimulating hormone rise: secondary surge and unilateral ovariectomy. Biol Reprod 43:347-352
14. Campbell CS, Schwartz NB, Firlit MG 1977 The role of adrenal and ovarian steroids in the control of serum LH and FSH. Endocrinology 101:162-172
15. Pleim ET, Cailliau PJ, Weinstein MA, Etgen AM, Barfield RJ 1990 Facilitation of receptive behavior in estrogen-primed female rats by the anti-progestin RU 486. Horm Behav 24:301-310
16. Mani SK, Allen JMC, Clark JH, Blaustein JD, O'Malley BW 1994 Convergent pathways for steroid hormone- and neurotransmitter-induced rat sexual behavior. Science 265:1246-1248
17. McGinnis MY, Krey LC, MacLuskey NJ, McEwen BS 1981 Steroid receptor levels in intact and ovariectomized estrogen-treated rats: an examination of quantitative, temporal and endocrine factors influencing the efficacy of an estradiol stimulus. Neuroendocrinology 33:158-165
18. Fox SR, Harlan RE, Shivers BD, Pfaff DW 1990 Chemical characterization of neuroendocrine targets for progesterone in the female rat brain and pituitary. Neuroendocrinology 51:276-283
19. Kraus WL, Montano MM, Katzenellenbogen BS 1994 Identification of multiple, widely space estrogen-responsive regions in the rat progesterone receptor gene. Mol Endocrinol 8:952-969
20. Kastner P, Krust A, Turcotte B, Stropp U, Tora L, Gronemeyer H, Chambon P 1990 Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO J 9:1603-1614
21. Horwitz K 1992 The molecular biology of RU486. Is there a role for antiprogestins in the treatment of breast cancer? Endocr Rev 13:146
22. Schrader WT 1993 Insight: subunit functions of the steroid/thyroid receptor family. Mol Endocrinol 7:1241-1243
23. Boyd-Leinen P, Gosse B, Rasmussen K, Martin-Dani G, Spelsberg TC 1984 Regulation of nuclear binding of the avian oviduct progesterone receptor. J Biol Chem 259:2411-2421
24. Baulieu E-E 1991 The antisteroid RU486: its cellular and molecular mode of action. Trends Endocrinol Metab 2:233-239
25. Meyer M-E, Pornon A, Jingwei J, Boquel M-T, Chambon P, Gronemeyer H 1990 Agonistic and antagonistic activities of RU486 on the functions of the human progesterone receptor. EMBO J 9:3923-3932
26. Beck CA, Weigel NL, Moyer ML, Nordeen SK, Edwards DP 1993 The progesterone antagonist RU486 acquires agonist activity upon stimulation of cAMP signaling pathways. Proc Natl Acad Sci USA 90:4441-4445
27. Waring DW, Turgeon JL 1992 A pathway for luteinizing hormone-releasing hormone self-potentiation: cross-talk with the progesterone receptor. Endocrinology 130:3275-3282
28. Power RF, Mani SK, Codina J, Conneely OM, O'Malley BW 1991 Dopaminergic and ligand-independent activation of steroid hormone receptors. Science 254:1636-1639
29. Smanik EJ, Young HK, Muldoon TG, Mahesh VB 1983 Analysis of the effect of progesterone in vivo on estrogen receptor distribution in the rat anterior pituitary and hypothalamus. Endocrinology 113: 15-22
30. Blaustein JD, Brown TJ 1984 Progesterone decreases the concentration of hypothalamic and anterior pituitary estrogen receptors in ovariectomized rats. Brain Res 304:225-236
31. Chalbos D, Galtier F 1994 Differential effect of forms A and B of human progesterone receptor on estradiol-dependent transcription. J Biol Chem 269:23007-23012
32. McDonnell DP 1995 Unraveling the human progesterone receptor signal transduction pathway-insights into antiprogestin action. Trends Endocrinol Metab 6:133-138
33. Knox KL, Bauer-Dantoin AC, Levine JE, Schwartz NB 1995 Unmasking of neuropeptide-Y inhibitory effects on in vitro gonadotropin secretion from pituitaries of metestrous, but not proestrous, rats. Endocrinology 136:187-194
34. Nordeen SK, Bona BJ, Moyer ML 1993 Latent agonist activity of the steroid antagonist, RU486, is unmasked in cells treated with activators of protein kinase A. Mol Endocrinol 7:731-742
35. Sartorius CA, Tung L, Takimoto GS, Horwitz KB 1993 Antagonist-occupied human progesterone receptors bound to DNA are functionally switched to transcriptional agonists by cAMP. J Biol Chem 268:9262-9266
36. Tung L, Mohamed MK, Hoeffler JP, Takimoto GS, Horwitz KB 1993 Antagonist-occupied human progesterone B-receptors activate transcription without binding to progesterone response elements and are dominantly inhibited by A-receptors. Mol Endocrinol 7:1256-1265
37. Schwartz NB, Talley WL 1978 Effects of exogenous LH and FSH on endogenous FSH, progesterone and estradiol secretion. Biol Reprod 18:820-828
38. Denner LA, Weigel NL, Maxwell BL, Schrader WT, O'Malley BW 1990 Regulation of progesterone receptor-mediated transcription by phosphorylation. Science 250:1740-1743
39. Kazmi SM, Visconti V, Plante RK, Ishaque A, Lau C 1993 Differential regulation of progesterone receptor A and B form-mediated trans-activation by phosphorylation. Endocrinology 133:1230-1238
40. Turgeon JL, Waring DW 1981 Acute progesterone and 17β-estradiol modulation of luteinizing hormone secretion by pituitaries of cycling rats superfused in vitro. Endocrinology 108:413-419
41. Turgeon JL, Waring DW 1994 Activation of the progesterone receptor by the gonadotropin-releasing hormone self-priming signaling pathway. Mol Endocrinol 8:860-869
42. Turgeon JL, Waring DW 1987 Adenosine 3′,5′-monophosphate primes the secretion of follicle-stimulating hormone. Endocrinology 120:1602-1607
43. Vegeto E, Shahbaz MM, Wen DX, Goldman ME, O'Malley BW, McDonnell DP 1993 Human progesterone receptor A form is a cell-and promoter-specific repressor of human progesterone receptor B function. Mol Endocrinol 7:1244-1255
44. McDonnell DP, Goldman ME 1994 RU486 exerts antiestrogenic activities through a novel progesterone receptor A form-mediated mechanism. J Biol Chem 269:11945-11949
45. Turgeon JL 1979 Estradiol-luteinizing hormone relationship during the proestrous gonadotropin surge. Endocrinology 105:731
46. Lee W-S, Smith MS, Hoffman GE 1990 Progesterone enhances the surge of luteinizing hormone by increasing the activation of luteinizing hormone-releasing hormone neurons. Endocrinology 127:2604-2606
47. Bilezikjian LM, Vaughan JM, Vale WW 1993 Characterization and the regulation of inhibin/activin subunit proteins of cultured rat anterior pituitary cells. Endocrinology 133:2445-2553
48. Bilezikjian LM, Corrigan AZ, Vaughan JM, Vale WW 1993 Activin-A regulates follistatin secretion from cultured rat anterior pituitary cells. Endocrinology 133:2554-2560