Restoration of the CCAAT box or insertion of the CACCC motif activate δ-globin gene expression

Blood

Volumn 90, Issue 1, 1997, Pages 421-427

  Tang, Delia C ^b   Ebb, David ^b   Hardison, Ross C ^b   Rodgers, Griffin P ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

DELTA GLOBIN;

ARTICLE; CELL STRAIN K 562; GENE DELETION; GENE EXPRESSION; GENE INSERTION; GENE MUTATION; GENE SEQUENCE; HELA CELL; HUMAN; HUMAN CELL; PLASMID; PRIORITY JOURNAL; PROMOTER REGION;

EID: 0030974492     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v90.1.421     Document Type: Article

References (29)

1. Steinberg MH, Adams JGI: Hemoglobin A2: Origin, evolution, and aftermath. Blood 78:2165, 1991
2. Nagel RL, Bookchin RM, Johnson J, Labie D, Wajcman H, Isaac-Sodeye WA, Honig GR, Schiliro G, Crookston JH, Matsutomo K: Structural bases of the inhibitory effects of hemoglobin F and hemoglobin A2 on the polymerization of hemoglobin S. Proc Natl Acad Sci U S A 76:670, 1979
3. Nagel RL, Sharma A, Kumar R, Fabry ME: Severe red cell abnormalities in transgenic mice expressing high levels of normal human delta chains. Blood 86:251a, 1995 (suppl 1, abstr)
4. Poillon WN, Kim BC, Rodgers GP, Noguchi CT, Schechter AN: Sparing effect of hemoglobin F and hemoglobin A2 on the polymerization of hemoglobin S at physiologic ligand saturations. Proc Natl Acad Sci USA 90:5039, 1993
5. Rodgers GP: Pharmacologic modulation of fetal hemoglobin, in Embury SH, Hebbel RP, Mohandas N, Steinberg MH (eds): Sickle Cell Disease: Basic Principles and Clinical Practice. New York, NY, Raven, 1994, p 829
6. Schechter AN, Rodgers GP: Sickle cell anemia - basic research reaches the clinic. N Engl J Med 332:1372, 1995 (editorial)
7. 2. Ann NY Acad Sci 165:54, 1969
8. Dover GJ, Boyer SH, Charache S, Heintzelman K: Individual variation in the production and survival of F cells in sickle-cell disease. N Engl J Med 299:1428, 1978
9. Trusov YA, Dear PH: A molecular clock based on the expansion of gene families. Nucleic Acids Res 24:995, 1996
10. Wood WG, Old JM, Roberts AV, Clegg JB, Weatherall DJ: Human globin gene expression: Control of beta, delta and delta beta chain production. Cell 15:437, 1978
11. Humphries RK, Ley T, Turner P, Moulton AD, Nienhuis AW: Differences in human alpha-, beta-delta-globin gene expression in monkey kidney cells. Cell 30:173, 1982
12. Spritz RA, DeRiel JK, Forget BG, Weissman SM: Complete nucleotide sequence of the human δ-globin gene. Cell 21:639, 1980
13. Huang XQ, Hardison RC, Miller W: A space-efficient algorithm for local similarities. Comput Appl Biosci 6:373, 1990
14. Higuchi R, Krummel B, Saiki RK: A general method of in vitro preparation and specific mutagenesis of DNA fragments: Study of protein and DNA interactions. Nucleic Acids Res 16:7351, 1988
15. Efstratiadis A, Posakony JW, Maniatis T, Lawn RM, O'Connell C, Spritz RA, DeRiel JK, Forget BG, Weissman SM, Slightom JL, Blechl AE, Smithies O, Baralle FE, Shoulders CC, Proudfoot NJ: The structure and evolution of the human beta-globin gene family. Cell 21:653, 1980
16. Miller IJ, Bieker JJ: A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Krüppel family of nuclear proteins. Mol Cell Biol 13:2776, 1993
17. Charnay P, Mellon P, Maniatis T: Linker scanning mutagenesis of the 5′-flanking region of the mouse beta-major-globin gene: Sequence requirements for transcription in erythroid and nonerythroid cells. Mol Cell Biol 5:1498, 1985
18. Dierks P, van Ooyen A, Cochran MD, Dobkin C, Reiser J, Weissmann C: Three regions upstream from the cap site are required for efficient and accurate transcription of the rabbit beta-globin gene in mouse 3T6 cells. Cell 32:695, 1983
19. Feng WC, Southwood CM, Bieker JJ: Analyses of beta-thalassemia mutant DNA interactions with erythroid Kruppel-like factor (EKLF), an erythroid cell - specific transcription factor. J Biol Chem 269:1493, 1994
20. Dean A, Ley TJ, Humphries RK, Fordis M, Schechter AN: Inducible transcription of five globin genes in K562 human leukemia cells. Proc Natl Acad Sci USA 80:5515, 1983
21. Emanuel PA, Gilmour DS: Transcription factor TFIID recognizes DNA sequences downstream of the TATA element in the Hsp70 heat shock gene. Proc Natl Acad Sci USA 90:8449, 1993
22. Orphanides G, Lagrange T, Reinberg D: The general transcription factors of RNA polymerase II. Genes Dev 10:2657, 1996
23. Purnell BA, Emanuel PA, Gilmour DS: TFIID sequence recognition of the initiator and sequences farther downstream in Drosophila class II genes. Genes Dev 8:830, 1994
24. Perkins AC, Sharpe AH, Orkin SH: Lethal beta-thalassemia in mice lacking the erythroid CACCC-transcription factor EKLF. Nature 375:318, 1995
25. Donze D, Townes TM, Bieker JJ: Role of erythroid Kruppel-like factor in human gamma-to beta-globin gene switching. J Biol Chem 270:1955, 1995
26. Donze D, Jeancake PH, Townes TM: Activation of delta-globin gene expression by erythroid Krupple-like factor: A potential approach for gene therapy of sickle cell disease. Blood 88:4051, 1996
27. Matsuda M, Sakamoto N, Fukumaki Y: Delta-thalassemia caused by disruption of the site for the erythroid-specific transcription factor, GATA-1, in the delta-globin gene promoter. Blood 80:1347, 1992
28. LaFlamme S, Acuto S, Markowitz D, Vick L, Landschultz W, Bank A: Expression of chimeric human beta-and delta-globin genes during erythroid differentiation. J Biol Chem 262:4819, 1987
29. Hardison R, Chao KM, Schwartz S, Stojanovic N, Ganetsky M, Miller W: Globin Gene Server: A prototype E-mail database server featuring extensive multiple alignments and data compilation for electronic genetic analysis. Genomics 21:3, 1994