Deoxygenation of 1,4-epoxides by Grignard reagents

Tetrahedron Letters

Volumn 38, Issue 27, 1997, Pages 4761-4764

  Blank, David H ^a   Gribble, Gordon W ^a  

^a Lamont Doherty Earth Observatory   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRACENE DERIVATIVE; NAPHTHALENE DERIVATIVE; REAGENT;

AROMATIZATION; ARTICLE; CHEMICAL MODIFICATION; CHEMICAL REACTION; GAS CHROMATOGRAPHY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SYNTHESIS;

EID: 0030974215     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)01022-8     Document Type: Article

References (24)

1. 2 flushed 25 mL 3 neck flask, and dissolved in THF with magnetic stirring. This solution was brought to reflux, at which time 10 equivalents of the Grignard reagent were added dropwise. In most cases the reaction was complete within 2 hours. The reaction was quenched with aqueous ammonium chloride, the product extracted into ethyl acetate, dried over sodium sulfate, filtered, concentrated and purified by flash chromatography.
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